News archive

Researchers at Karolinska Institutet have developed a novel strategy for identifying potent miniature antibodies, so-called nanobodies, against emerging SARS-CoV-2 variants. The approach led to the discovery of multiple nanobodies that in cell cultures and mice effectively blocked infection with different SARS-CoV-2 variants. The findings, which are described in the journals Nature Communications and Science Advances, could pave the way for new treatments against COVID-19.

Here, Center Director Hans-Gustaf Ljunggren present some personal recollections and reflections of research in the field of NK cells and work conducted in his laboratory over three decades, leading up towards the current utilization of NK cells in the context of human cancer immunotherapy.

Vaccination against COVID-19 during pregnancy is not associated with a higher risk of pregnancy complications, according to a large-scale registry study from Karolinska Institutet in Sweden and the Norwegian Institute of Public Health published in the journal JAMA.

A new study by researchers at Karolinska Institutet shows that the local activity of the signaling molecule Rac1 controls cycles of microscopic protrusions and retractions of the cell membrane. The cell uses these cycles to sense its surroundings, which among other things affects the cell's ability to move. Understanding of the cellular and molecular mechanisms that control cell movements, can help us to develop better diagnostics and treatment of various diseases such as cancer.

Cecilia Haddad Ringborg at the research group Surgical Care Science, Department of Molecular Medicine and Surgery, will defend her thesis "The perspective of being a family caregiver of a patient treated for oesophageal cancer : problems and needs" on April 1, 2022. Main Supervisor is Pernilla Lagergren.

Researchers at Karolinska Institutet have identified a protein that protects against breast tumour growth and that can be linked to a better prognosis in breast cancer patients. The results, which are published in the journal Nature Communications, may contribute to the development of new therapies for difficult-to-treat forms of breast cancer.

On March 16 the Minister for International Development Cooperation visited Karolinska Institutet to discuss current research about vaccination and development cooperation for health. The visit was made in conjunction with National Vaccination Week, which has the aim of achieving more people being vaccinated against Covid 19.

Late last year, preliminary studies revealed that the fast-spreading Omicron SARS-CoV-2 variant was likely to evade COVID-19 antibodies but, in many people, less so than expected. Now one of those studies from Karolinska Institutet has been published in the prestigious journal The Lancet Infectious Diseases. KI researcher Ben Murrell explains the findings and recalls the rush to understand the new variant.

Ulrika Marklund has been awarded the European Research Council’s Consolidator grant 2022 for research about how different neurons within the enteric nervous system (ENS) obtain their identities.

The causes of complex diseases can be identified by representing them in the form of mathematically produced networks. This method was used to find bacteria that drive atopic dermatitis, for example.

People who were bedridden for at least a week due to COVID-19 were more likely to experience anxiety and depression for up to 16 months after the infection, compared with those who only had mild symptoms or were never infected. That is according to a large study based on data from six countries and conducted by an international team of researchers including those from Karolinska Institutet and the University of Iceland. The findings are published in The Lancet Public Health.

The PREFERABLE II consortium, of which Yvonne Wengström is a member, has received EU funding for the project "Personalised Exercise-Oncology for improvement of supportive care: a super umbrella trial to demonstrate the (cost)effectiveness of live-remote exercise in cancer survivors."

There is a lack of understanding as to why some people suffer from long-lasting symptoms after COVID-19 infection. A new study from Karolinska Institutet in Sweden, the Helmholtz Center Munich (HMGU) and the Technical University of Munich (TUM), both in Germany, now demonstrates that a certain type of immune cell called macrophages show altered inflammatory and metabolic expression several months after mild COVID-19. The findings are published in the journal Mucosal Immunology.

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet have now found an unusual way of stabilising the protein and making it more potent. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells. The study is published in the journal Structure.

Researchers from the Division of Biochemistry, in collaboration with scientists from University of L'Aquila in Italy, Rush University and University of California San Francisco in the US, have now for the first time characterized the crystal structure and activity of the B. malayi and O. volvulus antioxidant systems, thereby paving the way for the development of more efficient targeted redox-based therapies.

Gunilla Lööf, affiliated with the Department of Learning, Informatics, Management and Ethics (LIME), is passionate about clinical implementation of research results and hopes for increased collaboration between clinic and academy. Her project The Anesthesia Web is now being highlighted in The Lancet.

Tyler Sandberg, Center for Infectious Medicine (CIM) at the Department of Medicine, Huddinge is defending his thesis "B cell responses to human flavivirus vaccination and SARS-CoV-2 infection" on March 18, 2022. Main Supervisor is Professor Hans-Gustaf Ljunggren.

The Swedish Kidney Foundation has appointed the researchers who will be receiving money this year for kidney research. Out of a total of 49 researchers and SEK 6.1 million, 19 researchers at Karolinska Institutet will share SEK 2.2 million. In connection with the recognition of the grants, one KI researcher will be awarded the Bengt Rippes Research Prize.

Tinnitus is the experience of annoying sounds that no one else can hear, a kind of phantom sound. The problem is increasing, probably due to exposure to high noise levels.

Karolinska Institutet’s Centre for Health Crises is to receive SEK 15 million grant from Marianne and Marcus Wallenberg Foundation. The money will be used to build up the centre and develop its activities over the coming two years.

On the occasion of World Kidney Day, HRH Prince Daniel invited seven Swedish kidney and transplant researchers for a discussion at the Royal Palace.

A team led by Karolinska Institutet has combined Artificial Intelligence (AI) with structural biology to gain insights into two similar proteins that prevent bacterial infection in the urinary tract and the gastrointestinal system. Their results are published in "Nature Structural & Molecular Biology".

Mild cognitive impairment (MCI) is considered the preclinical stage in progressive cognitive decline leading to the clinical stage of dementia. A study published in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, reports that over one fourth of rural-dwelling older adults in China are affected by MCI.

Sexual and gender-based harassment in the workplace can contribute to the development of mental ill-health requiring treatment with antidepressants and anti-anxiety medication, a study from Karolinska Institutet in Sweden published in the journal Occupational and Environmental Medicine reports.

Several researchers at KI have offered to host Ukrainian colleagues. Initiatives have been launched through, among others, the organisation EMBO, which supports research and researchers in the field of life science.

Parkinson's disease (PD) is a progressive and complex disorder that affects multiple parts of the brain but also other organ systems. Symptoms start gradually, sometimes with a barely noticeable tremor in just one hand. Tremor is common, and the disorder also commonly causes stiffness and slowing of movements. More than 10 million people worldwide are living with PD and the incidence increases dramatically with age.

Hi Irene Brusini, PhD student at the Division of Clinical Geriatrics, NVS. On March 25 you will defend your thesis ”Methods for the analysis and characterization of brain morphology from MRI images”, what's the main focus of the thesis?

She will take up the post at the association's annual conference in September 2022.

Women who have had one ovary surgically removed (unilateral oophorectomy) are less likely to become pregnant after in vitro fertilisation and give birth to fewer babies than women with both ovaries. That is according to an extensive meta-analysis published in the journal Fertility and Sterility by researchers at Karolinska Institutet.

Global warming is likely to increase the number of people requiring hospitalization due to critically low sodium levels in the blood, a condition known as hyponatremia. A new study from Karolinska Institutet projects that a temperature rise of 2 degrees Celsius would increase the burden on hospitals from hyponatremia by almost 14 percent. The findings are published in the Journal of Clinical Endocrinology and Metabolism.

Researchers at Karolinska Institutet have studied long-term morbidity and mortality in individuals who have had different models of biological heart valves implanted. The results, which show that there are considerable differences in performance depending on model group, are published in the journal JAMA Network Open.

Karolinska Institutet and Karolinska University Hospital have strengthened collaboration within precision medicine by establishing the Precision Medicine Centre Karolinska (PMCK) and have now entered into a unique cooperation agreement.

Karolinska Institutet's core facilities are generally highly rated by the users. This can be seen from the results of the open survey conducted in November and December 2021 on behalf of the Infrastructure Council. But there is still potential for improvement in areas such as websites and support given to clinical researchers, according to the working group behind the survey.

Researchers behind the science of how we move have been recognized with the The Brain Prize 2022. Ole Kiehn, from the Department of Neuroscience at Karolinska Institutet and at the University of Copenhagen, Denmark, is one of three neuroscientists receiving the world's largest prize for brain research, awarded on a yearly basis by the Lundbeck Foundation.

While the large proportion of our genome that does not instruct our cells to form proteins has been harder to study than protein-coding genes, it has been shown to have vital physiological functions. Scientists at Karolinska Institutet have now developed new high-precision tools able to identify what these noncoding sequences do. The study, which is published in the journal Nature Genetics, may eventually contribute to the development of new, targeted drugs.

The February sun was glittering in the glazed facades when Karolinska Institutet welcomed Minister for Education Anna Ekström on Monday 28 February. Meanwhile, the situation grew gloomier in Ukraine, which was demonstrated by, amongst other things, a lecture in disaster medicine.

Fatigue, or severe tiredness and exhaustion, is a distressing condition for many patients with advanced cancer. Unfortunately, good pharmacological treatment options are limited, and the ones available come with a risk of side effects and/or habituation.

His excellency the Ambassador of Japan to Sweden, Masaki Noke, visited KI on 24th November, 2022, to explore the institution and world leading research ongoing at KI.

The Department of Global Public Health (GPH) has got two new doctoral student representatives; Soha el Halabi and Katrine de Angeles. They represent the students in meetings and committees at the department and work to help and support new and existing doctoral students.

The Selivanova's group at MTC recently established a multidisciplinary collaboration together with Dr. Marie-Stéphanie Aschtgen, microbiologist in the Henriques-Normark groups (also at MTC) to study the interplay between bacteria and cancer, focusing on how specific bacterial systems influence host tumor supressors. Together they recently got their first collaborative paper accepted in Oncogene, entitled "Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization".

Last week Reza Rasti obtained his doctoral degree after successfully defending his thesis titled ‘Point-of-care diagnostics of childhood central nervous system infections, with a focus on usability in low-resource settings'. The defence took place in lecture hall David in the Widerströmska building and joining via zoom from Uganda was his opponent Philippa Musoke, Professor at Makerere University.

On the 3rd of March, doctoral student Vanda had her half-time seminar online via Zoom and in Widerströmska huset. Vanda is a Mozambican healthcare practitioner specialising as a pediatric surgeon in Spain and is now using her experiences from clinical work into research in her thesis titled:
‘Acute pediatric injury in a low-resource African setting during the COVID-19 pandemic: Insight on injury epidemiology and care from the largest hospitals of Mozambique’

Nikolaos Christidis term commences in June 2022 and he will serve as President of the group during 2023-2024.

Caroline Ran, researcher at the Department of Neurosicence, has been awarded the Harold Wolff-John Graham Award in recognition of her outstanding achievements in headache research. The award, sponsored by the American Academy of Neurology (AAN), amounts to 1000 USD, plus 200 USD in subsistence allowance to speak at AAN's annual meeting in April 2022.

Preprint servers are a mixed bag of important research papers and articles of more dubious quality. The Preprint Club sifts out the nuggets that are worthy of our attention – and has now been joined by scientists from Karolinska Institutet.

The Swedish Childhood Cancer Fund has decided to grant SEK 150 million in grants to Swedish childhood cancer research, of which SEK 60 million to a total of 32 researchers at Karolinska Institutet.

COMMENTARY Last night’s military aggression against Ukraine must be condemned in the strongest possible terms, comments the KI president Ole Petter Ottersen on the military aggression against Ukraine.

Johan von Schreeb, professor of global disaster medicine and director of the Centre for Research on Health Care in Disasters at Karolinska Institutet, has been named director of KI’s newly established Centre for Health Crises. The aim is to create a center based on KI’s knowledge and capability, that finds connections between groups and people, with the aim of increasing preparedness for a new pandemic or health crisis.

The EU has granted Karolinska Institutet support for several new projects under the Horizon Europe programme, the Union's most important funding programme for research and innovation. The largest of them is PARC, which will contribute to the safer management of chemicals and improve the dialogue between researchers and authorities.

Threats or violence in the workplace is never acceptable. Hatred, threats and harassment against researchers, but also against other occupational groups, is unfortunately not a new phenomenon but has lately also increased, especially among employees working with research related to COVID-19. This is of course a very unfortunate development and KI wants to raise awareness of the support that is available to you as an employee.