Tuberculosis programs should focus more on young people, researchers say
Researchers at Karolinska Institutet, among others, have mapped key factors that affect the treatment outcomes in 10- to 24-year-olds with tuberculosis in Brazil, where the disease is increasing. To deal with the global tuberculosis epidemic, researchers say that greater focus is needed on this age group in tuberculosis programs. The study is published in The Lancet Global Health.
New findings on B cells may improve vaccine design
Our bodies can fine-tune the immune response to an infection and make it proportional to the threat at hand. New research from Karolinska Institutet describes how B lymphocytes, the immune cells that make antibodies, choose between different cell fates to balance the magnitude of the acute immune response and the memory response that protects against future threats. The study, published in Immunity, may contribute to the optimisation of vaccines to fight viruses or other pathogens.
KI researchers awarded 1.56 million US dollar NIH Prime grant for research on Alzheimer's disease
Docent Sara Hägg, together with a multidisciplinary team of KI researcher, has been awarded an NIH Prime Grant for their research on repurposing drugs for the primary prevention of Alzheimer’s Disease. The grant is for three years with the option to apply for additional two years.
Only a minority of those with alcohol use disorders receives medication
Only a minority of Swedes with alcohol use disorders are prescribed alcohol medication, a situation that has remained largely unchanged in the country since the mid-2000. That is according to a study at Karolinska Institutet published in the journal Drug and Alcohol Dependence. Prescriptions of alcohol medication are also unevenly distributed in the society, the study found.
Link between ADHD and dementia across generations
A large study at Karolinska Institutet has found a link between ADHD and dementia across generations. The study, published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, shows that parents and grandparents of individuals with ADHD were at higher risk of dementia than those with children and grandchildren without ADHD.
New apartments for researchers and students on campus Solna
After several years of planning and construction, 316 new apartments are now ready for researchers and students at KI to move into. Collins Santhansamy is one of the newly arrived students at KI Residence Solna.
Precision medicine at the centre during German state visit
On 8 September, the German President, H.E. Frank-Walter Steinmeier and H.M. King Carl XVI Gustaf visited Karolinska Institutet and Karolinska University Hospital.
Even low levels of air pollution can increase cardiovascular disease risk
Prolonged exposure to air pollution can be linked to an increased risk of stroke and coronary heart disease, even when levels are below the limits specified by the EU and WHO. This has been shown, among others, by researchers at Karolinska Institutet and Helmholtz Zentrum München in a large European study published in The Lancet Planetary Health.
The new coronavirus
Genetic risk factors for severe COVID-19 identified
In March 2020, thousands of researchers across the globe joined forces to answer the question of why some COVID-19 patients develop a severe, life-threatening disease, while others manage with mild or no symptoms. A comprehensive summary of their findings to date, based on the analyses of nearly 50,000 patients and published in Nature today, reveals 13 genetic regions that are strongly associated with infection or severe COVID-19.
A limited selection of recent publications in high impact journals to which researchers at KI have contributed.
Defective gene on the X chromosome behind severe COVID-19 in men
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19, Asano T et al, Science Immunology, August 2021
Autoantibodies against type I interferons may explain 20% of COVID-19 related deaths
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, Bastard P et al, Science Immunology, August 2021
Lectins may reduce SARS-CoV-2 variants infectivity
Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites, Mirazimi A et al, EMBO Journal, augusti 2021
Declined incidence of celiac disease despite more intestinal biopsies
Two waves of celiac disease incidence in Sweden: a nationwide population-based cohort study from 1990-2015, Bergman D et al, GUT, July 2021.
New method to analyse direct cell-cell interaction in tissue
An unsupervised method for physical cell interaction profiling of complex tissues, Andrews N et al, Nature Methods, July 2021.
Challenges and opportunities for treatment of PCOS
Epigenetic inheritance of polycystic ovary syndrome – challenges and opportunities for treatment, Stener-Victorin E, Deng Q, Nature Reviews Endocrinology, July 2021.
Increased mortality among children and young adults with fatty liver
Non-alcoholic fatty liver disease in children and young adults is associated with increased long-term mortality, Simon TG et al, Journal of Hepatology, July 2021.
More high impact publications
KI in the media
The Macchiarini case: timeline
Creating a better future for all children
Professor Stefan Swartling Peterson isn’t interested in getting more papers published. No, he wants to spend the last ten years of his career helping to create a better future for all children. And time’s running out.
The Conversation: Hope for natural immunity makes little sense
COVID infections may give more potent immunity than vaccines. But according to KI researcher Charlotte Thålin, that doesn’t mean you should try to catch it. Find this news article and others from KI, recently published by the news site The Conversation.
Spotlight on Vaccine Research
Vaccines have saved lives for more than 200 years, but the research area continues to evolve with new discoveries that provide more effective and safer vaccines. Doors are now opening to develop vaccines against, for example, cancer, dementia and cardiovascular disease. The COVID-19 pandemic has given vaccine research a real boost.