Research on COVID-19

Top-publications list

A limited selection of recent publications in high impact journals to which researchers at KI have contributed.

 

Folding patterns of the genome give clues on identify of brain cells
Cell-type specialization is encoded by specific chromatin topologies
Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, et al, Nature, November 2021
 

Cells need Topoisomerase 1 to remember what to do after they divide
Topoisomerase 1 activity during mitotic transcription favors 1 the transition from mitosis to G1
Anika Wiegard et al, Molecular Cell, November 2021


New knowledge on why prostate cancer so commonly spread to the bone
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment, Kfoury Y, Baryawno N, Severe N, Sykes DB, Kharchenko PV as part of the Boston Bone Metastases Consortium, Cancer Cell, October 2021.

Tumour DNA in blood accumulates in exosomes
Extracellular vesicles are the primary source of blood-borne tumour-derived mutant KRAS DNA early in pancreatic cancer, Daniel W. Hagey et al, Journal of Extracellular Vesicles, October 2021.

Defective gene on the X chromosome behind severe COVID-19 in men
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19, Asano T et al, Science Immunology, August 2021.

Autoantibodies against type I interferons may explain 20% of COVID-19 related deaths
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, Bastard P et al, Science Immunology, August 2021.

More high impact publications

KI in the media