Locomotor engine in the spinal cord revealed
Researchers at Karolinska Institutet have revealed a new principle of organisation which explains how locomotion is coordinated in vertebrates akin to an engine with three gears. The results are published in the scientific journal Neuron.
Researcher: What we know about the new corona virus
Nine people have died and more than 400 have been sickened by the new corona virus spreading in China. A few cases have been confirmed in Taiwan, Thailand, South Korea, Japan and the U.S., and on Wednesday, the World Health Organization is holding an emergency meeting on the outbreak. How worried about a new pandemic should we be? Virus researcher Ali Mirazimi, adjunct professor at the Department of Laboratory Medicine at Karolinska Institutet, gives us his perspective.
New opportunity for cancer drug development
After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in the scientific journal Nature Communications, open for new strategies to treat different types of cancer.
Proteins that protect against joint inflammation identified
Endogenous proteins that play a vital part in allergies and parasitic infection can prevent the immune system from wrongly attacking the body and causing inflamed joints, a study from Karolinska Institutet published in the scientific journal PNAS reports. The researchers hope that the results will give rise to new drugs for rheumatoid arthritis.
Belly fat linked to increased risk for recurrent heart attacks
Abdominal obesity not only increases the risk for a first heart attack or stroke, but also the risk for recurrent atherosclerotic cardiovascular disease, according to a study by researchers at Karolinska Institutet published in the European Journal of Preventive Cardiology.
Cheap drug may alleviate treatment-resistance in leukemia
A common drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), according to a study in mice and human blood cells published in the medical journal EMBO Molecular Medicine. The researchers will now launch a clinical study to test the new combination treatment in patients.
Swedish Foundations’ Starting Grant to KI researcher Emma Andersson
KI researcher Emma Andersson receives Swedish Foundations' Starting Grant 2019 for research in developmental biology. The Swedish Foundation's Starting Grant is a collaboration between five foundations that fund the most promising researchers at Swedish educational institutions.
New discovery on function of MAIT cells during acute HIV infection
In a study in Nature Communications, researchers at Karolinska Institutet show that MAIT cells respond with dynamic activity and reprogramming of gene expression during the initial phase of HIV infection. The study fills a knowledge gap, as previously there has been a lack of awareness of the function of MAIT cells during this particular phase.
Long-term medication for schizophrenia is safe
Researchers at Karolinska Institutet and their colleagues in Germany, the USA and Finland have studied the safety of very long-term antipsychotic therapy for schizophrenia. According to the study, which is published in the scientific journal World Psychiatry, mortality was higher during periods when patients were not on medication than when they were.
A limited selection of recent publications in high impact journals where researchers from KI are main authors.
Increased risk of IBD among patients with microscopic colitis
Microscopic Colitis and Risk of Inflammatory Bowel Disease in a Nationwide Cohort Study, Khalili H et al, Gastroenterology, Jan 2020.
Suicide rates decline worldwide except in the US
Suicide, Fazel S, Runeson B, NEJM, Jan 2020.
Genes predict tamoxifen treatment outcome in breast cancer
CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer, He W et al, Journal of Clinical Oncology, Dec 2019.