The new coronavirus
Immunological cause of severe COVID-19 identified
More than 10 percent of young and previously healthy people who develop severe COVID-19 have misguided antibodies that attack the immune system itself, and another 3.5 percent carry a specific genetic mutation. This is according to new research published in Science by an international consortium involving researchers at Karolinska Institutet in Sweden.
SARS-CoV-2 during pregnancy was not associated with complications in neonates
In a study published in JAMA researchers at Karolinska Institutet and Karolinska University Hospital have examined the association between a positive SARS-CoV-2 test during pregnancy and complications in mothers and their newborn babies. Almost two out of three pregnant women who tested positive for SARS-CoV-2 were asymptomatic and the researchers found no higher prevalence of complications during delivery or of ill-health in the neonates. However, preeclampsia was more common in infected women.
A cheaper, faster COVID-19 test
Researchers at Karolinska Institutet have developed a method for fast, cheap, yet accurate testing for COVID-19 infection. The method simplifies and frees the testing from expensive reaction steps, enabling upscaling of the diagnostics. The study is published in Nature Communications.
Find out more at the COVID-19 Resource Hub
Researchers at Karolinska Institutet are responding to the new coronavirus, SARS-CoV-2, through a myriad of initiatives. For more news and features on the work being conducted at Karolinska Institutet, including vaccine and drug development, please see the COVID-19 Resource Hub.
Top-publications list
A limited selection of recent publications in high impact journals to which researchers at KI have contributed.
Promising results in case study of COVID-19 drug candidate APN01
Human recombinant soluble ACE2 in severe COVID-19, Ali Mirazimi et al, The Lancet Respiratory Medicine, September 2020.
New knowledge on the effect of periodic fasting in over-weight men
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression, Lundell LS, Nature Communications, September 2020.
Gene analysis may improve precision in treatment of certain neuroblastoma
Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN-Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group, Ambros IM et al, Journal of Clinical Oncology, September 2020.