New possible treatment strategy against fatty liver disease
Researchers at Karolinska Institutet in Sweden have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies for treating the condition, which is a major health risk for people with obesity. The study is published in the scientific journal Science Translational Medicine.
Cognitive impairment after intensive care linked to long-lasting inflammation
People who have been treated in intensive care commonly suffer from residual cognitive impairment, but the reason for this is unknown. Researchers at Karolinska Institutet now link cognitive impairment with lasting inflammation and a potential treatment target. The results are presented in the scientific journal Intensive Care Medicine.
Proactivity and freedom of speech discussed at ethics seminar
International collaboration, lively debates and going above and beyond legal requirements – those were some examples of how Karolinska Institutet may work proactively with ethics discussed in the Ethics Council’s latest seminar. The event also featured a lecture by Justice Thomas Bull who voiced support for organizational cultures that encourage constructive criticism of their own operations.
War-zone study helps improve care for vulnerable patients
Researchers at Karolinska Institutet in Sweden have carried out the first randomised trial of civilians with acute conflict-related wounds at two hospitals in areas affected by armed conflict. The study, which is published in The Lancet Global Health, shows that a new, more costly method of wound treatment is not more effective than standard treatment.
KI-researchers seek to develop vaccine against new corona virus
Researchers worldwide are trying to develop a vaccine and antiviral treatments against the new corona virus spreading in China. At Karolinska Institutet, virus researchers Ali Mirazimi and Matti Sällberg are working to develop a prototype vaccine against the virus. But vaccine development takes time, and it will likely take at least six to nine months before an application for clinical studies can be filed and another two to three years before a vaccine could be ready for the public.
Skin moisturizers failed to prevent atopic eczema in babies
Babies regularly treated with bath oil and skin cream are no more protected from developing atopic eczema than other babies, according to a study at Karolinska Institutet and the University of Oslo in Norway. The findings are published in The Lancet.
New cholesterol-lowering guidelines would increase cost of treatment
The financial burden on health systems would drastically increase if new European expert guidelines for cholesterol-lowering treatment were implemented, according to a new simulation study by researchers at Karolinska Institutet, published in the European Heart Journal. The findings highlight an urgent need for cost-effectiveness analysis, according to the researchers.
IVF-conceived children have somewhat higher mortality risk in their first weeks of life
Children conceived with assisted reproductive techniques have a somewhat higher mortality risk during their first weeks of life than children conceived naturally, according to a study from Karolinska Institutet, published in the journal Fertility and Sterility. The researchers link the increased risk to a higher degree of premature births in IVF-conceived children. The risk of infant mortality is still very small for both groups and after 1 year of age there is no difference.
Gene therapy can protect against ALS and SMA-related cell death
Researchers at Karolinska Institutet and the University of Milan have identified a gene in human neurons that protects against the degeneration of motor neurons in the deadly diseases ALS and SMA. Gene therapy in animal models of these diseases was shown to protect against cell death and increase life expectancy. The study is published in Acta Neuropathologica.
A limited selection of recent publications in high impact journals where researchers from KI are main authors.
Web tool for meta-analysis give new insights on muscles and exercise at a molecular level
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity, Pillon NJ et al, Nature Communications, Jan 2020.
Increased risk of IBD among patients with microscopic colitis
Microscopic Colitis and Risk of Inflammatory Bowel Disease in a Nationwide Cohort Study, Khalili H et al, Gastroenterology, Jan 2020.
Suicide rates decline worldwide except in the US
Suicide, Fazel S, Runeson B, NEJM, Jan 2020.