Lipid biomarkers in urine can determine the type of asthma
In a new study, researchers at Karolinska Institutet have used a urine test to identify and verify a patient’s type of asthma. The study, which has been published in the American Journal of Respiratory and Critical Care Medicine, lays the foundation for a more personalized diagnosis and may result in improved treatment of severe asthma in the future.
The new coronavirus
New small antibodies show promising effects against COVID-19 infection
Researchers at Karolinska Institutet have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells. The research study, published in Science, shows that a combined nanobody had a particularly good effect – even if the virus mutated. According to the researchers, the nanobodies have the potential to be developed into a treatment for COVID-19.
Weaker skin barrier leads to faster uptake of chemicals
The ability of our skin to protect us from chemicals is something we inherit. Some people are less well-protected which could imply an increased risk of being afflicted by skin disease or cancer. A new study from Karolinska Institutet that has been published in Environmental Health Perspectives shows how the rate of uptake of common chemicals is faster in people with a genetically weakened skin barrier.
Good results for groin hernia operations not performed by doctors in Sierra Leone
An international study led by researchers at Karolinska Institutet shows that inguinal hernia operations performed by associate clinicians at a hospital in Sierra Leone were just as safe and effective as those performed by doctors. The study, a collaboration with Kamakwie Wesleyan Hospital, is published in JAMA Network Open.
Anna Martling named Cancer Researcher of the Year
The Swedish Cancer Society has awarded the prestigious title Cancer Researcher of the Year 2021 to Anna Martling, professor of surgery at Karolinska Institutet and senior consultant colorectal surgeon at Karolinska University Hospital, as well as dean of KI Nord.
Alarming information about Ahmadreza Djalali
The situation about the death sentence against the former KI researcher and Swedish citizen Ahmadreza Djalali is still alarming and might soon be carried out.
Advances in research on the most general type of stem cells
Stem cell research is the prerequisite for regenerative medicine, which with the help of the body's cells recreates and heals important organs. Now, researchers at KI have found a method for defining the most general type of stem cells, that can develop into all cell types in the body. The study of totipotent stem cells in mice has been published in Nature Cell Biology.
Antioxidants Vitamin C and Vitamin E Linked to Lower Risk of Parkinson’s
People who consume high levels of vitamin C and E in their diet may have a lower risk of Parkinson’s disease than people who get only small amounts of these nutrients, according to a new study from University of Milano-Bicocca, Italy, and Karolinska Institutet. The study was published in Neurology.
A limited selection of recent publications in high impact journals to which researchers at KI have contributed.
No reduced risk of extremely preterm birth during the pandemic
Preterm Birth and Stillbirth During the COVID-19 Pandemic in Sweden: A Nationwide Cohort Study, Björn Pasternak et al, Annals of Internal Medicine, January 2021.
A molecular map of tissue-specific human innate lymphoid cells
Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing, Jenny Mjösberg et al, Cell Research, January 2021.
Biomarkers reveal early and late alterations in the course of Alzheimer's disease
Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer’s disease, Joana B Pereira, Brain, December 2020.
Study suggests novel therapeutic strategy in AD at a molecular level
Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization, Ibáñez CF et al, EMBO Journal, December 2020.
Both conventional and biologics treatment effective in early rheumatoid arthritis
Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial
Merete Lund Hetland et al, BMJ, December 2020.
More high impact publications
KI in the media
The Macchiarini case: timeline
Marie Carlén: She wants to decode the brain
Sherlock Holmes was an idol when she was a child and her mother suggested the research profession early on. But it was not a straight path to science for Marie Carlén. Today she leads advanced studies on the part of the brain that shapes us as individuals: the prefrontal cortex.
Spotlight on COVID-19
In early 2020, a new coronavirus was identified in China, and it has now caused a worldwide pandemic. The official name for this virus is SARS-CoV-2, and the disease that is caused by the virus is called COVID-19. Here we present news and features about KI's efforts to stop the new coronavirus.