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New opportunity for cancer drug development

After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in the scientific journal Nature Communications, open for new strategies to treat different types of cancer.

Proteins that protect against joint inflammation identified

Endogenous proteins that play a vital part in allergies and parasitic infection can prevent the immune system from wrongly attacking the body and causing inflamed joints, a study from Karolinska Institutet published in the scientific journal PNAS reports. The researchers hope that the results will give rise to new drugs for rheumatoid arthritis.

Belly fat linked to increased risk for recurrent heart attacks

Abdominal obesity not only increases the risk for a first heart attack or stroke, but also the risk for recurrent atherosclerotic cardiovascular disease, according to a study by researchers at Karolinska Institutet published in the European Journal of Preventive Cardiology.

Cheap drug may alleviate treatment-resistance in leukemia

A common drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), according to a study in mice and human blood cells published in the medical journal EMBO Molecular Medicine. The researchers will now launch a clinical study to test the new combination treatment in patients.

Swedish Foundations’ Starting Grant to KI researcher Emma Andersson

KI researcher Emma Andersson receives Swedish Foundations' Starting Grant 2019 for research in developmental biology. The Swedish Foundation's Starting Grant is a collaboration between five foundations that fund the most promising researchers at Swedish educational institutions.

New discovery on function of MAIT cells during acute HIV infection

In a study in Nature Communications, researchers at Karolinska Institutet show that MAIT cells respond with dynamic activity and reprogramming of gene expression during the initial phase of HIV infection. The study fills a knowledge gap, as previously there has been a lack of awareness of the function of MAIT cells during this particular phase.

Long-term medication for schizophrenia is safe

Researchers at Karolinska Institutet and their colleagues in Germany, the USA and Finland have studied the safety of very long-term antipsychotic therapy for schizophrenia. According to the study, which is published in the scientific journal World Psychiatry, mortality was higher during periods when patients were not on medication than when they were.

Colorectal cancer risk remains despite modern treatment for ulcerative colitis

Patients with the inflammatory bowel disease ulcerative colitis have a higher risk of dying from colorectal cancer, despite modern therapy, even though the risk has declined in recent years. This is according to a new study published in the scientific journal The Lancet by a team of Swedish and Danish researchers.

AI can be used to detect and grade prostate cancer

Researchers have developed a method based on artificial intelligence for histopathological diagnosis and grading of prostate cancer. The study, presented in The Lancet Oncology, shows that the AI-system is as good at identifying and grading prostate cancer as world-leading uro-pathologists. The technology has the potential to solve one of the bottlenecks in today’s prostate cancer.

Top-publications list

A limited selection of recent publications in high impact journals where researchers from KI are main authors.

Increased risk of IBD among patients with microscopic colitis
Microscopic Colitis and Risk of Inflammatory Bowel Disease in a Nationwide Cohort Study, Khalili H et al, Gastroenterology, Jan 2020.

Suicide rates decline worldwide except in the US
Suicide, Fazel S, Runeson B, NEJM, Jan 2020.

Genes predict tamoxifen treatment outcome in breast cancer
CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer, He W et al, Journal of Clinical Oncology, Dec 2019.

More high impact publications

KI in the media

The Macchiarini case: timeline

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View a summary of the events and decisions in the Macchiarini case.

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Professors' inauguration

On Thursday, 17 October 2019, thirteen new professors were inaugurated at Karolinska Institutet in solemn forms in Aula Medica. The professor's inauguration ceremony is one of the highlights of the academic year of our university.

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Top-publications list

New opportunity for cancer drug development

Proteins that protect against joint inflammation identified

Belly fat linked to increased risk for recurrent heart attacks

Cheap drug may alleviate treatment-resistance in leukemia

Swedish Foundations’ Starting Grant to KI researcher Emma Andersson

New discovery on function of MAIT cells during acute HIV infection

Long-term medication for schizophrenia is safe

Colorectal cancer risk remains despite modern treatment for ulcerative colitis

AI can be used to detect and grade prostate cancer

Top-publications list

KI in the media

The Macchiarini case: timeline

Follow KI in social media

Professors' inauguration

President‘s blog

Chairman's blog