Hope for children with high-risk neuroblastoma
Thanks to many years of translational research, some children with the rare childhood cancer neuroblastoma may now be cured. In a new study, researchers at among others Karolinska Institutet and University of Gothenburg write that so-called ALK inhibitors should be used to treat children with high-risk neuroblastoma. That is after an analysis showed that children with mutations in the ALK gene have poorer prognosis.
Immune cells in the human biliary system mapped
Researchers at Karolinska Institutet have analysed and described in detail the immune cells residing in the human bile duct. The findings may pave the way for new treatment strategies against disorders of the bile duct, which are often linked to immunological processes. The study is published in the journal Science Translational Medicine.
The new coronavirus
Parental training and child CBT effective for children with disruptive behavioural disorders
Early intervention for disruptive behaviour disorders in children reduces the risk of antisocial development and psychiatric problems later in life. Parental training and child CBT are two interventions about which more needs to be known concerning the effects on disruptive behaviour disorders. According to a new doctoral thesis from Karolinska Institutet, both have a positive effect on such disorders, where severity should determine the choice of treatment.
Contact with sperm donors aroused many emotions
Sweden was the first country in the world to introduce open-identity sperm donation, whereby adult children are entitled to obtain information about their donors. Researchers at Karolinska Institutet have now explored how such contacts and relations affect the parents of these young men and women. The study, which is published in Human Reproduction, shows that mothers often find it easier to accept the new situation.
First months decisive for immune system development
Many diseases caused by a dysregulated immune system, such as allergies, asthma and autoimmunity, can be traced back to events in the first few months after birth. To date, the mechanisms behind the development of the immune system have not been fully understood. Now, researchers at Karolinska Institutet show a connection between breast milk, beneficial gut bacteria and the development of the immune system. The study is published in Cell.
Several persistent chemicals were found in fetal organs
Researchers at Karolinska Institutet found industrial chemicals in the organs of fetuses conceived decades after many countries had banned the substances. In a study published in the journal Chemosphere, the researchers urge decision makers to consider the combined impact of the mix of chemicals that accumulate in people and nature.
Low income increases risk of recurrent heart attacks
More knowledge is needed about risk factors for recurrent cardiovascular disease and myocardial infarction. In his thesis, doctor Joel Ohm at the Department of Medicine, Solna, Karolinska Institutet, describes how socio-economic factors have a major impact on secondary prevention efforts and prognosis. The results may have an impact on people who have survived myocardial infarction.
Common vaccine protects against more HPV viruses than previously known
The human papillomavirus (HPV) can cause cancer and many countries run national vaccination programmes to minimise the risk. Studies involving researchers at KI now report on the longitudinal effect of common HPV vaccines. The results, which are published in The Journal of Infectious Diseases and Lancet Infectious Diseases, show lasting protection against more HPV variants than the vaccines were developed for.
Immediate skin-to-skin contact after birth improves survival of pre-term babies
Continuous skin-to-skin contact starting immediately after delivery even before the baby has been stabilised can reduce mortality by 25 per cent in infants with a very low birth weight. This according to a study in low- and middle-income countries coordinated by the WHO on the initiative of researchers at Karolinska Institutet published in The New England Journal of Medicine.
A limited selection of recent publications in high impact journals to which researchers at KI have contributed.
New insights on exercise adaptation at a molecular level
Time trajectories in the transcriptomic response to exercise — a meta-analysis, Amar D, Lindholm ME, Norrbom J, Wheeler MT, Rivas MA, Ashley EA, Nature Communications, June 2021.
Severe COVID-19 may be driven by RAAS imbalance
COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system, Rysz S et al, Nature Communications, April 2021.
One step closer toward understanding the origin of neuroblastoma
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin, Kameneva P et al, Nature Genetics, April 2021.
Personalized care the way forward to reduce obesity and type 2 diabetes
Metabolic Consequences of Obesity and Type 2 Diabetes: Balancing Genes and Environment for Personalized Care, Pillon NJ et al, Cell, March 2021.
More high impact publications
KI in the media
The Macchiarini case: timeline
She wants to understand long-term COVID
As a tuberculosis researcher, she is accustomed to studying airborne pandemic contagion. Early in the current pandemic, Judith Bruchfeld saw the need to assemble various experts to investigate long-term illness after COVID-19. “There’s a lot we don’t understand yet.”
The Conversation: COVID during pregnancy poses a low risk to newborns
According to KI researcher Mikael Norman, babies born to women who have tested positive for COVID-19 do not need to be routinely separated from their mothers at birth. Find this news article and others from KI, recently published by the news site The Conversation.
Spotlight on Vaccine Research
Vaccines have saved lives for more than 200 years, but the research area continues to evolve with new discoveries that provide more effective and safer vaccines. Doors are now opening to develop vaccines against, for example, cancer, dementia and cardiovascular disease. The COVID-19 pandemic has given vaccine research a real boost.