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Many diseases caused by a dysregulated immune system, such as allergies, asthma and autoimmunity, can be traced back to events in the first few months after birth. To date, the mechanisms behind the development of the immune system have not been fully understood. Now, researchers at Karolinska Institutet show a connection between breast milk, beneficial gut bacteria and the development of the immune system. The study is published in Cell.
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Eva Karlöf at the research group Vascular Surgery, the Department of Molecular Medicine and Surgery, will defend her thesis "Improving stroke risk prediction and individualised treatment in carotid atherosclerosis" on June 18, 2021. Main Supervisor is Professor Ulf Hedin.
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Researchers at Karolinska Institutet found industrial chemicals in the organs of fetuses conceived decades after many countries had banned the substances. In a study published in the journal Chemosphere, the researchers urge decision makers to consider the combined impact of the mix of chemicals that accumulate in people and nature.
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What do you know about ATMPs? Equip yourself for the future – learn the basics of Advanced Therapy Medicinal Products (ATMP). Join in and take the Swedish healthcare into the future!
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In a study published in Nature Communications, researchers at Karolinska Institutet provide insight into the sequence of events leading to formation of functional mitoribosomes and sheds light on the mechanism of action of nine mitoribosome assembly factors involved in this process. The results may help yield novel opportunities for diagnosis and therapeutic intervention for mitochondrial diseases as well as cancer or diabetes.
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High blood lipids and inactivity are two risk factors for atherosclerosis in humans. When the European brown bear (Ursus arctos) hibernates during winter, it is inactive for 5-6 months and also develops high blood lipids, but still show no signs of atherosclerosis.
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Based on the assessment that the spread of COVID-19 is expected to decrease and that vaccinations will take place according to plan, KI is planning for a return to campus-based education during the fall semester.
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Two research environments from Karolinska Institutet have been awarded grants for follow-up studies of COVID-19 vaccines. In total, six research environments from five universities will share SEK 100 million from the Swedish Research Council. The research environments are based on collaborations between different regions, and will focus on different aspects of health and medical care needs.
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The Stockholm Writers Group (SWG) published an anthology entitled "Raft of Leaves: On Aging, Death and Foreignness" on 29 May 2021, in remembrance of Marti Parker (1951–2017), researcher, teacher, novelist, poet, and one of the founders of SWG.
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Researchers at Karolinska Institutet describe the relationship between infectious agents and dementia in an article recently published in Frontiers in Cellular Neuroscience.
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Jiaojiao Zheng from the research group Upper GI Surgery, the Department of Molecular Medicine and Surgery, will defend her thesis "Diabetes, metformin and gastric adenocarcinoma" on June 11, 2021. Main Supervisor is Professor Jesper Lagergren.
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Sorrento Therapeutics, Inc. announced their entry into an additional collaborative agreement with research groups at Karolinska Institutet, aimed at producing novel cell-based therapeutics using NK cells derived from induced pluripotent stem cells (“iPSCs”). Sorrento and KI are collaborative partners in NextGenNK.
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Researchers at Karolinska Institutet have investigated how a newly developed algorithm in connection with gene analysis can be used to improve the possibilities of preventing premature vascular disease and death in individuals with the hereditary lipid disorder, familial hypercholesterolemia. The findings, published in the Journal of Internal Medicine, show how the method can lead to faster and more cost-effective investigations in such families.
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By end of 2021 Sweden will probably have up to 100,000 Long COVID patients and globally there will be more than 20 million. These estimates are based on current rates of infection and that 10% of patients have longer term symptoms after a COVID-19 infection.
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Center for Alzheimer Research (CAR) has started a working group on sex and gender differences in dementia. The group is led by Assistant professors Shireen Sindi and Daniel Ferreira at the Division for Clinical Geriatrics. It's their first working group and they are excited to see how this group will evolve.
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Hi there, Ying Wang, PhD student at the Division of Neurogeriatrics! On June 23 you will defend your thesis “Neuroinflammation and its resolution in Alzheimer's disease". What is the main focus of your thesis?
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It´s graduation time at Karolinska Institutet! On the third and fourth of June we celebrate graduating bachelor’s and masters’ students through live-streamed ceremonies from Aula Medica. We want to wish you the best of luck on your future endeavors and say great job – you did it!
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Hi there, Gita Rajan, PhD student at the Division of Family Medicine and Primary Care! On June 22 you will defend your thesis “Sexual violence - epidemiology, treatment and access to health care". What is the main focus of your thesis?
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An article in Nature Reviews Nephrology summarizes the significant role of nitric oxide in the regulation of renal function and the link to cardiovascular disease and diabetes. Mattias Carlström, Associate Professor of Physiology at KI, is the author behind the article.
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More knowledge is needed about risk factors for recurrent cardiovascular disease and myocardial infarction. In his thesis, doctor Joel Ohm at the Department of Medicine, Solna, Karolinska Institutet, describes how socio-economic factors have a major impact on secondary prevention efforts and prognosis. The results may have an impact on people who have survived myocardial infarction.
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A Swedish COVID-19 data portal has now been in operation for a year and forms part of a European network aimed at promoting data sharing and access to data-related resources. The data portal has contributed to increased support for a large number of research projects and publications.
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By analyzing 4,000 drugs’ ability to affect cells’ capacity to produce proteins, researchers at Karolinska Institutet found that an anticancer therapy currently trialed in human patients works differently than previously thought. As many human diseases have alterations in this process called translation, the new knowledge contributes to a better understanding of how translation is regulated and the biological routes that regulate it. The study is published in PLOS Biology.
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University students in Stockholm reported no tangible differences in depression, anxiety or stress during the first few months of the COVID-19 pandemic, a longitudinal study at Sophiahemmet University and Karolinska Institutet finds. The study is published today in Scandinavian Journal of Public Health.
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What lessons have we learned during the COVID-19 pandemic and what are the primary hurdles that must be removed to attain equitable and sustainable health? These were the focal points of the Stockholm Life Science Conference 2021 that took place on the 25th of May. Three areas that were identified as important conditions for future innovations were collaboration, communication and accessibility to data.
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Joana Pereira officially starts as research group leader today, June 1, although she has been managing her own group for a while now.
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This year, The Academic Ranking of World Universities (ARWU) ranks KI as the fourth best university worldwide regarding nursing. Only the University of Pennsylvania (USA), Griffith University (Australia) and Johns Hopkins University (USA) rank higher, making nursing at KI number one in Europe.
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Hi there, Anna Svensson-Raskh, PhD student at the Division of Physiotherapy! On June 18 you will defend your thesis “Mobilization immediately after elective abdominal surgery – Respiratory effects and patients' and healthcare professionals' experiences". What is the main focus of your thesis?
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The human papillomavirus (HPV) can cause cancer and many countries run national vaccination programmes to minimise the risk. Studies involving researchers at German Cancer Research Center, Karolinska Institutet and Tampere University now report on the longitudinal effect of common HPV vaccines. The results, which are published in The Journal of Infectious Diseases and Lancet Infectious Diseases, show lasting protection against more HPV variants than the vaccines were developed for.
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Studying the implementation of public health interventions typically involves the identification of “facilitators” and “barriers”. In the case of active tuberculosis case-finding (also referred to as community-based tuberculosis screening), many studies have documented facilitators and barriers, but only few have explored the “how-to” of capitalizing on facilitators and overcoming barriers to put active case-finding into practice. This new study contributes to filling this gap.
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Continuous skin-to-skin contact starting immediately after delivery even before the baby has been stabilised can reduce mortality by 25 per cent in infants with a very low birth weight. This according to a study in low- and middle-income countries coordinated by the WHO on the initiative of researchers at Karolinska Institutet published in The New England Journal of Medicine.
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Hi there, Lorena Galán-Acosta, PhD student at the Division of Neurogeriatrics! On June 17 you will defend your thesis “Recombinant BRICHOS domains delivered over the blood-brain barrier : a possible way to treat Alzheimer's disease”. What is the main focus of your thesis?
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We are seeking healthy subjects for a brain imaging study on the effect of neuronal stimulation on learning and reward processing.
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In a study published in Nature Metabolism, researchers at the department of Cell and Molecular Biology developed a novel technique to identify small molecules that can make insulin-producing β-cells divide.
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Hi there, Sarah Wallcook, PhD student at the Division of Occupational Therapy! On June 10 you will defend your thesis “Conditions of everyday technology use and its Interplay in the lives of older adults with and without dementia”. What is the main focus of your thesis?
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Researchers at the Karolinska Institutet, University of Oxford and University of Copenhagen have shown that elevated levels of lipids known as ceramides can be associated with a ten-fold higher risk of death from cardiovascular disease. Treatment with liraglutide could keep the ceramide levels in check, compared with placebo. The results have been published in the Journal of the American College of Cardiology.
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Researchers at Karolinska Institutet and UCL have identified a general factor called ‘decision acuity’ that affects young people's decision-making ability, independent of IQ, and is associated with good social functioning. The results have been published in the journal Neuron.
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For decades, scientists have studied the health benefits of exercise – but this research has largely ignored the fact that how you spend the rest of the day may also matters. Instead of the recommendation that everyone should strive to achieve 150 minutes of weekly exercise, our results show physical activity recommendations can been more personalized. People can adopt a combination of activity that works best for them.
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An exciting new way has been found in which the body senses a bacterial infection within 4 hours and uses nerve pathways to trigger an immune response in distant organs. The speed by which an infection can be identified, and how the defence mechanisms are triggered is critical to infection outcome.
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Meet the 16 COVID-X Data and AI Solutions selected in the Open Call #1
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Congratulations to Elin Hardell at the department of Oncology-Pathology who gets award for best thesis 2020 from Swedish society of pathology!
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Young children who practice visual working memory and reasoning tasks improve their math skills more than children who focus on spatial rotation exercises, according to a large study by researchers at Karolinska Institutet in Sweden. The findings support the notion that training spatial cognition can enhance academic performance and that when it comes to math, the type of training matters. The study is published in the journal Nature Human Behaviour.
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The common skin disease atopic eczema (AE) impacts heavily on the life quality and general health of sufferers. Researchers at Karolinska Institutet have now evaluated its treatment with internet-delivered cognitive behavioural therapy (iCBT). The study suggests that patients feel better after iCBT compared with a control group who received only traditional treatment. The results, which are published in JAMA Dermatology, might eventually make important care available to a large patient group.
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With this postdoctoral programme SRP Diabetes aims to support the next generation of exceptional young scientists within the diabetes area, including both experimental and clinical research. To promote cross-fertilization between research environments, we encourage scientists wishing to pursue postdoctoral training in a different university from where they carried out doctoral studies. Openings for fellowships in 5 different laboratories at Karolinska Institutet.
Deadline June 6!
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Researchers at Karolinska Institutet have investigated the use of low dose venetoclax, an experimental drug, for the treatment of the heterogeneous cancer disease multiple myeloma in patients who had relapsed on standard therapies. The findings are published in the American Journal of Hematology and provide new hope for the treatment of multiple myeloma.

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Hi there, Haohao Wu, PhD student at the Department of Neuroscience at Karolinska Institutet! You will defend your thesis entitled "The molecular basis of the development and diversity of proprioceptive neurons : a story of surviving and thriving" on 21 May 2021.
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Glaucoma involves a high risk of losing sight. Researchers at Karolinska Institutet and St. Erik Eye Hospital, among others, have now studied the effects of nicotinamide, the amide of vitamin B₃, on animal and cell models for glaucoma. The study, published in Redox Biology, may be a future neuroprotective therapy in glaucoma in humans. A clinical trial will start in the autumn.
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Social anxiety disorder can cause considerable suffering in children and adolescents and, for many with the disorder, access to effective treatment is limited. Researchers at Centre for Psychiatry Research at Karolinska Institutet and Region Stockholm have now shown that internet-delivered cognitive behavioural therapy is an efficacious and cost-effective treatment option. The study is published in the journal JAMA Psychiatry.
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New research at Karolinska Institutet suggests a link between psychosis and a genetic change that affects the brain's immune system. The study published in Molecular Psychiatry may impact the development of modern medicines for bipolar disorder or schizophrenia.
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Obsessive-compulsive disorder (OCD) in children and adolescents is associated with impaired education and worse general health later in life. Access to specialist treatment is often limited. According to a study from Centre for Psychiatry Research at Karolinska Institutet and Region Stockholm, internet-delivered cognitive behavioural therapy (CBT) can be as effective as conventional CBT. The study, published in the prestigious journal JAMA, can help make treatment for OCD more widely accessible.
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Hi there, Konstantinos Poulakis, PhD student at the Division of Clinical Geriatrics! On May 28 you will defend your thesis “Alzheimer’s disease heterogeneity assessment with MRI biomarkers and unsupervised statistical learning”. What is the main focus of your thesis?
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2021-06-08