News archive

Researchers from Karolinska Institutet have discovered a new molecular mechanism by which cancer cells safeguard themselves from oncogene-induced replication stress and propose a strategy to deactivate this protective mechanism. The study is published in the scientific journal Molecular Cell.

KI researcher Yihai Cao and his research group at the Department of Microbiology, Tumor and Cell Biology, have defined a new biomarker for predicting drug resistance of antiangiogenic therapy for the treatment of various cancers. The study is published in PNAS.

We are excited to announce that we are in the process of acquiring a new sorter for our Flow Cytometry Core Facility at Biomedicum. This acquisition aims to expand our sorting capacity, allowing us to better accommodate the needs of our researchers.

We are thrilled to announce the latest additions to our core facility. We have recently acquired two Sony ID7000 spectral analyzers, Alice and Howard. These analyzers are equipped with advanced features, including five lasers and an array of 147 detectors, enabling high-resolution spectral analysis.

The 5D Heart Patch Project, led by Prof Kenneth Chien, has identified human ventricular progenitor (HVP) cells that can create self-assembling heart grafts in vivo. The research has the potential to offer hope to millions of people suffering from heart failure.

Jelena Misic, PhD in Nils-Göran Larsson Group at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, has been selected to participate in the Lindau Nobel Laureate Meetings in June 2023. Jelena studies different aspects of mitochondrial gene expression in mammals.

In a recently published article published in Nature Reviews Drug Discovery, Professor Yihai Cao’s research group at the Department of Microbiology, Tumor and Cell Biology, charts the information about drug development for the treatment of a number of human diseases by targeting new blood vessel formation.

The group of expert coordinators at the Centre for Health Crises keeps growing. The expert coordinators manage the work that is done within their field of expertise. The latest area of expertise to be added to the Centre is laboratory and diagnostic preparedness, with Jessica Alm as expert coordinator.

The FM newsletter is sent to all employees working in Biomedicum about twice a semester and includes news from the Facility Management. 

The Svedberg prize 2023 is awarded to Simon Elsässer, Department of Medical Biochemistry and Biophysics at Karolinska Institutet, for his contributions to our understanding of epigenetic gene regulation.

A new study published in Nature reports that a technology known as spatial omics can be used to map simultaneously how genes are switched on and off and how they are expressed in different areas of tissues and organs. This improved technology, developed by researchers at Yale University and Karolinska Institutet, could shed light on the development of tissues, as well as on certain diseases and how to treat them.

The first detailed description of the microbiota and immune cells among asymptomatic Helicobacter pylori-infected individuals has been published by researchers at Karolinska Institutet. The results of the study will be instrumental to understand the complex microbiome and immunity network and provide new insights for asymptomatic Helicobacter pylori infection.

Researchers at Karolinska Institutet uncover the function of the release factor mtRF1 in the final steps of mitochondrial protein synthesis. The study, published in Nature Communications, reveals new insights into a fundamental process in mitochondria.

Researchers at Karolinska Institutet and Stockholm University have developed a new technology allowing simultaneous probing of several different histone marks in one individual cell and in thousands of cells at the same time. This new method allows to investigate in much greater detail how cells in the mouse brain acquire unique properties and specialize. The study is published in the journal Nature Biotechnology.

Critical illness myopathy (CIM) is a common complication affecting ventilator-treated intensive care patients, which can lead to increased mortality/morbidity, prolonged hospital care, impaired patient quality of life, and increased healthcare costs. reported molecular pathogenesis of CIM during prolonged ICU stay, and potential diagnostic biomarkers and therapeutic targets. The study was recently published in Journal of Cachexia, Sarcopenia and Muscle.

The widely used gene scissor (CRISPR/Cas) can modify the genetic content in cells to study the molecular roles of genes and has gained great clinical relevance in gene therapy to treat genetic diseases. A new study performed by Claudia Kutter’s research group at the Department of Microbiology, Cell, and Tumor Biology at Karolinska Institutet, found that the gene scissor leads to unexpected genomic changes.

Researchers at Karolinska Institutet Qiaolin Deng and Georgios Sotiriou receive the KI Research Incubator (KIRI) Fellow postdoc grant 2022. The KIRI Fellow grant finances a postdoc for a collaborative interdisciplinary project. The awarded project aims to expand the use of tailored nanoparticles as drug carriers to deliver them to a dysfunctional placenta providing treatments to improve the child’s metabolic health.

Researchers at Karolinska Institutet have in a new study used cellular reprogramming to create human three-dimensional brain models and infected these models with SARS-CoV-2. In infected models, the brain immune cells excessively eliminated synapses and acquired a gene expression pattern mimicking what has been observed in neurodegenerative disorders. The findings could help to identify new treatments against persistent cognitive symptoms after a Covid-19 infection.

Professor Yihai Cao, Department of Microbiology, Tumor and Cell biology, is the corresponding author of a study recently published in PNAS, explaining how brown adipose tissue (BAT) can be increased in the adult human body.

As of August 2022 Christina Johansson is new head of administration at the Department of Physiology and Pharmacology (FyFa). Christina has worked in various roles and departments at KI since 2015, most recently as head of administration at the Unit for Teaching and Learning (UoL).

In a recently published article in the journal Trends in Microbiology, author Alberto J. Martin-Rodriguez, Senior Research Specialist at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet, explains how he found that distinct bacterial strains selectively use respiration for surface colonization.

In a new publication in Nature communications, Martin Rottenberg and Ruining Liu, professor and PhD student at the Department of Microbiology, Tumor and Cellbiology, explains how T cell protection against Tuberculosis is controlled by their oxygen responses.

New research from Yihai Cao research group at the Department of Microbiology, Tumor and Cellbiology, MTC, shows that the so-called brown fat in the human body seems to be able to prevent cancer tumors from growing. The result is published by Nature and has been widely disseminated in the media lately.

In a recently published review article in Cell, researchers Jon Lundberg and Eddie Weitzberg at the Department of Physiology and Pharmacology at Karolinska Institutet summarize research in nitric oxide (NO) with a focus on what is happening right now.

A new study from the Department of Neuroscience at Karolinska Institutet characterises a novel neuronal population in the basal ganglia, responsible for the interaction between two types of neurotransmitters, GABA and acetylcholine. The study was recently published in Cell Reports.

Using gene expression data from different cell types in the inner ear and brain, researchers have been able to identify the cell types that mainly contribute to hearing loss. The findings confirm that hearing loss does not derive from the brain but from a distinct compartment in the cochlea, called the stria vascularis, which is the “powerhouse” of the inner ear. The study has been published in the American Journal of Human Genetics.

Heart progenitors spontaneously regenerate cardiac muscle via a tight junction “honeycomb” in salamanders. Whether there are endogenous adult heart progenitors that can replenish damaged muscle cells remained controversial.

Tinnitus is the experience of annoying sounds that no one else can hear, a kind of phantom sound. The problem is increasing, probably due to exposure to high noise levels.

The Selivanova's group at MTC recently established a multidisciplinary collaboration together with Dr. Marie-Stéphanie Aschtgen, microbiologist in the Henriques-Normark groups (also at MTC) to study the interplay between bacteria and cancer, focusing on how specific bacterial systems influence host tumor supressors. Together they recently got their first collaborative paper accepted in Oncogene, entitled "Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization".

On November 24, H.M. Queen Letizia of Spain, H.M. Queen Silvia and H.R.H. Crown Princess Victoria Karolinska Institutet and Karolinska University Hospital.

Biofabrication and Tissue Engineering (Biofab) is a new core facility at Biomedicum, Karolinska Institutet.

Six researchers at FyFa have been granted project funds from the Swedish research council to the amount of 22 million SEK.

Federico Iovino, Assistant Professor and group leader at the Department of Neuroscience, Karolinska Institutet, has been recognised "World Expert" in the field "Streptococcus pneumoniae” by Expertscape, a website that objectively ranks physicans, researchers and institutions by their expertise in more than 29,000 biomedical topics.

Medicinska Föreningen (MF) in Stockholm is the largest student union at Karolinska Institutet. Every year MF awards a teacher with the award Mäster, to someone who has been teaching for an extended period of time, in an inspirational and pedagogical way or who initiated and implemented lasting improvements in the education. This year the award goes to Ellinor Kenne. It's the first time in a long time that someone at FyFa receives this award, and with the large amount of teaching that the departm

Professor Juleen R. Zierath receives the 2021 prestigious EASD Claude Bernard Award. This award recognizes an individual’s innovative leadership and lifetime achievements in diabetes research and is the EASD’s highest award.

Four questions to FyFa employees Rebecka Jakobsson, HR-partner and Duarte Ferreira, Assistant professor, about their experiences participating in FyFa Health Challange.

Jill Ziesmer, PhD student is interviewed in Karolinska institutets podcast Medicinvetarna no 77. The podcast is available on Spotify and podcasts.nu, among others.

Unfortunately, there have been a number of thefts both from the bicycle garage and from other places in Biomedicum during the past month.
We therefore ask you to think about locking your bikes and electric scooters properly, to not leave any valuables in the open, and
call the Biomedicum security guard if you see anything suspicious or someone unauthorized in the building.

Patients with chronic rhinosinusitis sometimes suffer from the growth of polyps in the nasal cavity. These polyps are difficult to treat and often require surgical intervention. Even after removal by surgery, polyps can return and present a significant health burden for patients.

Assistant professor Nicolas Pillon at the Department of Physiology and Pharmacology, has been awarded the prestigious Novo Nordisk Foundation Future Leaders Award from the European Foundation for the Study of Diabetes (EFSD).

Fyfa professor Magnus Ingelman- Sundberg has been appointed honorary doctor at the University of Southern Denmark.

This year Ulf von Euler lecture; "Molecular genetic studies of central nervous system vascular development and disease" is held by Professor Jeremy Nathans, Professor of molecular biology and genetics, neuroscience and ophthalmology at the Johns Hopkins University School of Medicine (Baltimore, MD. USA). He is also a Howard Hughes Medical Institute Investigator.

Gunnar Schulte, professor in receptor pharmacology at FyFa was interviewed by Dr Yamina Berchiche earlier this year in the podcast Dr. GPCR.

In a recently published review article in Nature Reviews Endocrinology, two researchers at the Department of Physiology and Pharmacology at KI, concludes where the field of research is today regarding causes behind and development of, Polycystic Ovary Syndrome (PCOS) and how epigenetic processes can contribute to the development of the syndrome.

New results presented by the Schulte lab at Karolinska Institutet in collaboration with researchers in Shanghai and Montréal, help us understand how the cell surface receptor FZD7 is activated and provides a platform for drug discovery to inhibit this process for therapeutic purposes.

Andrea Carmine Belin, researcher at the Department of Neuroscience, has been nominated and elected to the International Headache Society's Board of Directors for a two-year period (2021-2023), which will also be announced in conjunction with the Members' Annual Meeting on September 9, 2021.

Researchers from Karolinska Institutet have discovered how platinum-chemotherapy can enhance the treatment resistance of ovarian cancer cells, by progressively changing the cancer cell-intrinsic adhesion signaling and cell-surrounding microenvironment.

An article in Nature Reviews Nephrology summarizes the significant role of nitric oxide in the regulation of renal function and the link to cardiovascular disease and diabetes. Mattias Carlström, Associate Professor of Physiology at KI, is the author behind the article.

Hi there, Haohao Wu, PhD student at the Department of Neuroscience at Karolinska Institutet! You will defend your thesis entitled "The molecular basis of the development and diversity of proprioceptive neurons : a story of surviving and thriving" on 21 May 2021.

Researchers at Karolinska Institutet show how a certain type of immune cells, macrophages, can be recruited into breast cancer tumors, where they are reprogrammed to support and drive tumor growth. In a study published in the scientific journal PNAS, they describe that low levels of the tumor suppressor protein TAp73 lead to hyperactivation of NFkB signaling and an inflammatory condition in breast cancer as well as secretion of molecules that recruit tumor-promoting macrophages into the tumor.