News archive

Causal inference is important in medical research to help determine if treatments are beneficial and if natural exposures are harmful. In many settings, data collection makes causal inference difficult without making overly optimistic or idealistic assumptions. In a new article published in the Journal of the American Statistical Association, researchers at Karolinska Institutet develop new statistical methods to make causal inference possible in some settings without making such assumptions.

On Monday 12 October, the Stockholm County Administrative Board arranged a programme of royal visits to see how the local health authority is handling the COVID-19 pandemic. Their first stop was Karolinska Institutet.

Guidelines for treatment are often established based on drug development and research performed in relation to the Western world. Eleni Aklillu wants to contribute to the appropriate use of drugs adapted for conditions in sub-Saharan Africa.

Hi Helena Cleeve, PhD student at the Division of Occupational Therapy (NVS). On November 6 you will defend your thesis “Mundane mattering : how materialities come to matter in everyday life in dementia care units and in end of life care”. What’s the main focus of the thesis?

Yenan Bryceson researches certain types of primary immuno-deficiencies that lead to overactive parts of the immune system and severe illness. The goal is to understand human immunological diseases, establish accurate diagnostics and contribute to improved treatments.

When the skin barrier is defect, inflammatory skin diseases such as atopic dermatitis can arise. Maria Bradley is engaged in research focusing on the genetic causes of the disease and how they vary in populations in different parts of the world.

Inger Kull is engaged in research focusing on children and young people’s allergies and the patient’s transition from paediatrics to adult care. Much of her research is linked to the BAMSE Project she co-founded 26 years ago.

Researchers from Karolinska Institutet demonstrate that genetic risk score for ADHD can influence how autistic individuals respond to standard interventions and the specific program on social skills training KONTAKT®. This study is now published in npj Genomic Medicine.

Olof Sköldenberg’s research aims to contribute to better treatment and diagnosis of injured joints – especially hip joints. In recent years, among other activities, he has investigated how artificial intelligence (AI) can be used as support in the analysis of orthopaedic X-ray images.

Susanne Guidetti develops methods and interventions for rehabilitating people who have had a stroke and for supporting older people. Her interventions are based on person-centred care, digital support and activities where the individual’s own priorities are in focus.

When a society is shattered into rubble by a disaster, people generally want to help. But without knowledge and coordination, the efforts are often misdirected. Johan von Schreeb conducts research on how global disaster medicine interventions can be made more efficient and effective.

Christian Rück is a psychiatrist who researches different types of obsessive-compulsive disorders – both causes and treatments. He has developed Internet-based cognitive behavioral therapy (CBT) that is currently used in psychiatry in Sweden as well as abroad.

Erika Franzén is engaged in research on exercise that improves balance and gait for people with Parkinson’s disease. Her pro-gramme HiBalance, which poses significant physical challenges to the patients, has proven to be both effective and much appreciated.

When we draw conclusions in our everyday lives, what we learn is often linked to emotions – such as that a particular matter is important, a person has a high status, or that an environment is frightening. Andreas Olsson studies how this learning takes place in social situations.

Much of Fang Fang’s research concerns ALS. Although her background is in epidemiology, she likes to integrate other types of research. In her view, multidisciplinary collaboration is key to understand and, in the long run, to cure the disease.

Eric Westman combines brain imaging with machine learning to search the whole brain for the mechanisms behind neuro-degenerative disorders. An important element of his research is to identify different subtypes of diseases such as Alzheimer’s.

The health benefits of exercise are well known, but healthcare needs to become better at actually using physical activity as a treatment. This is the opinion of Maria Hagströmer, who is engaged in research concerning the relationship between physical activity and health.

If you have a computer with an earlier version of Windows 10, you need to perform a mandatory update of the operating system. The update can take up to two hours, however installed programs/applications will not be affected by the update.

Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis. Now, researchers at Karolinska Institutet in Sweden and Massachusetts General Hospital in the U.S. show that mortality increases with disease severity, but even mild fatty liver disease is linked to higher mortality. The findings have been published in the scientific journal Gut.

Researchers at Karolinska Institutet rapidly generate new knowledge on the importance of different groups of drugs and the development of hyponatremi. In the present study, lithium treatment was compared between 11,213 individuals hospitalized due to hyponatremia and 44,801 controlls. Interestingly, lithium treatment was half as common among individuals with hyponatremia. The results were recently published in Journal of Psychopharmacology.

Georgios Sotiriou, Researcher at the Department of Microbiology, Tumor and Cell Biology receives the Smoluchowski award for his research contribution to the fields of aerosol science and technology. The award consists of a certification and a personal prize of 2.000 €.

A study lead by KI researcher and SciLifeLab Fellow Simon Elsässer elucidates a new flavour of heterochromatin, used by embryonic stem cells to silence ‘parasitic’ DNA-elements within the context of their highly dynamic pluripotent chromatin. The study was recently published in Nature Communications.

The Royal Swedish Academy of Sciences have decided to award the 2020 Nobel Prize in Chemistry to Emmanuelle Charpentier and Jennifer A. Doudna for the development of a method for genome editing. Here, KI researchers who uses the method in their own research comment on this year’s prize. “It’s what we’ve been waiting for,” says Fredrik Lanner.

KI researchers receive 52 120 000 SEK in Forte's yearly call within the areas of responsibility: health, working life and welfare. The purpose of the call is to allow for analysis of advanced knowledge and to contribute to such knowledge in designated research areas or issues.

Eleni Aklillu is Professor in Tropical Pharmacology and research group leader at Department of Laboratory Medicine and has been awarded the prestigious RSTMH Donald Mackay Medal.

Eleni Aklillu is Professor in Tropical Pharmacology and research group leader at Department of Laboratory Medicine and has been awarded the prestigious RSTMH Donald Mackay Medal.

The 2020 Nobel Prize in Physiology or Medicine is awarded for the discovery of the hepatitis C virus. Thanks to the work of the laureates, it is now possible to detect the virus in blood and to provide an effective treatment for the infection. It has saved the lives of millions of people. The prize also focuses on the importance of research into viruses.

NVS congratulates Ann-Helen Patomella, Lena von Koch, Maria Hagströmer and Neda Agahi!

Hi Hanna Johansson, PhD student at the Division of Physiotherapy, NVS. On October 23 you will defend your thesis “Balance and gait in Parkinson’s disease : from perceptions to performance”. What’s the main focus of the thesis?

During the autumn and spring term, the Department of Medical Biochemistry and Biophysics participates in a project on the department management's communication channels and internal communication at the department. The aim is to gain a better understanding of how communication works today and how it can be developed in the future.

The Nobel Assembly at Karolinska Institutet has today decided to award the 2020 Nobel Prize in Physiology or Medicine jointly to Harvey J. Alter, Michael Houghton, and Charles M. Rice for their discoveries of the Hepatitis C virus.

Meet Agneta Richter Dahlfors, director of a new interdisciplinary research centre with the focus on societal benefits, that was inaugurated on 30 September. What is AIMES?

The Center for the Advancement of Integrated Medical and Engineering Sciences, AIMES, is a collaboration between KTH Royal Institute of Technology and Karolinska Institutet, in partnership with Getinge, with the vision to enhance the exchange of expertise within academia and industry. The center was officially inaugurated on 30 September 2020, in Biomedicum, Solna (and via Youtube).

Researchers at Karolinska Institutet have identified a protein in the brain that is important both for the function of the mood-regulating substance serotonin and for the release of stress hormones, at least in mice. The findings, which are published in the journal Molecular Psychiatry, may have implications for the development of new drugs for depression and anxiety.

Herwig Schüler, Department of Biosciences and Nutrition, KI, is co-applicant in a project lead by Umeå University, which are about to receive almost SEK 30 million in project grant from the Knut and Alice Wallenberg Foundation (KAW) for a project on "Decoding bacterial toxin-antitoxin systems: from high-throughput discovery to molecular mechanisms and biotechnology".

Spinal cord injury often leads to permanent functional impairment. In a new study published in the journal Science researchers at Karolinska Institutet show that it is possible to stimulate stem cells in the mouse spinal cord to form large amounts of new oligodendrocytes, cells that are essential to the ability of neurons to transmit signals, and thus to help repair the spinal cord after injury.

KI is now taking the next step and establishing a new team – KI’s interdisciplinary resource team post COVID-19 (KIRP) – to handle future challenges and to help improve and strengthen preparedness for future crises, such as new pandemics. 

Women vaccinated against HPV have a significantly lower risk of developing cervical cancer, and the positive effect is most pronounced for women vaccinated at a young age. That is according to a large study by researchers at Karolinska Institutet in Sweden published in New England Journal of Medicine.

A study published in Nature shows that a segment of DNA that causes their carriers to have an up to three times higher risk of developing severe COVID-19 is inherited from Neandertals. The study was conducted by researchers at Karolinska Institutet and Max Planck Institute for Evolutionary Anthropology.

Four major research projects at Karolinska Institutet are to receive project grants from the Knut and Alice Wallenberg Foundation (KAW) this year. A total of almost SEK 143 million over a five-year period is to be invested in KI projects on cellular ageing, cerebral decision-making mechanisms, stem-cell fate and antibody-producing cells.

A type of anti-bacterial T cells, so-called MAIT cells, are strongly activated in people with moderate to severe COVID-19 disease, according to a study by researchers at Karolinska Institutet in Sweden that is published in the journal Science Immunology. The findings contribute to increased understanding about how our immune system responds against COVID-19 infection.

Women receiving fertility-sparing surgery for treatment of borderline ovarian tumours were able to have children, a study from Karolinska Institutet in Sweden published in Fertility & Sterility shows. Natural fertility was preserved in most of them and only a small proportion required assisted reproductive treatment such as in vitro fertilization. Survival in the group was also as high as in women who had undergone radical surgical for treatment of similar tumours.

Barbara Canlon was elected as a foreign member of the medical science class at the Royal Swedish Academy of Sciences on March 12, 2020.

More than 10 percent of young and previously healthy people who develop severe COVID-19 have misguided antibodies that attack the immune system itself, and another 3.5 percent carry a specific genetic mutation. This is according to new research published in Science by an international consortium involving researchers at Karolinska Institutet in Sweden.

Researchers at KI have received funding from the United States Army for the development of genetic engineering methods to alleviate or cure the disease Duchenne muscular dystrophy (DMD), the most common form of genetic neuromuscular disease in children.

In a study published in JAMA researchers at Karolinska Institutet and Karolinska University Hospital have examined the association between a positive SARS-CoV-2 test during pregnancy and complications in mothers and their newborn babies. Almost two out of three pregnant women who tested positive for SARS-CoV-2 were asymptomatic and the researchers found no higher prevalence of complications during delivery or of ill-health in the neonates. However, preeclampsia was more common in infected women.

Nils-Göran Larsson receives a project grant in Endocrinology & Metabolism of DKK 2 million from the Novo Nordisk Foundation. We’ve talked to him about the project that investigates the role of mitochondria in the development of obesity-associated insulin resistance.

New knowledge on the cellular makeup and growth of teeth can expedite developments in regenerative dentistry – a biological therapy for damaged teeth – as well as the treatment of tooth sensitivity. The study, which was conducted by researchers at Karolinska Institutet, is published in Nature Communications.

Researchers at Karolinska Institutet have developed a method for fast, cheap, yet accurate testing for COVID-19 infection. The method simplifies and frees the testing from expensive reaction steps, enabling upscaling of the diagnostics. This makes the method particularly attractive for places and situations with limited resources, for repeated testing and for moving resources from expensive diagnostics to other parts of the care chain. The study is published in Nature Communications.