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In a study published in PNAS, researchers from Karolinska Institutet, the Royal Institute of Technology (KTH), Nagoya University and Technische Universität Braunschweig show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types.
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In a new study researchers at Karolinska Institutet and KTH Royal Institute of Technology have developed a new kind of brain atlas based on an innovative method of mapping brain tissue into areas according to their molecular profile. The study is published in Science Advances.
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StratNeuro has awarded SEK 1,000,000 in start-up grant to each of the following KI recipients of a 2019 VR ‘starting grant’.
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StratNeuro received 37 submissions from across 9 departments for the 2020 postdoctoral research grants. After evaluation from 10 external invited reviewers, we are happy to announce that StratNeuro will fund the 15 top ranked submissions (shown below in alphabetical order).
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Researchers from Karolinska Institutet and Nanyang Technological University (NTU) in Singapore have found that the claustrum is organised into functional connectivity modules rather than a hub-like structure, which up until now, was the prevailing idea. The study was recently published in Current Biology.
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Congratulations to Andrea Carmine Belin and Caroline Ran, researchers at the Department of Neuroscience, who have received The Swedish Brain Foundation's Research Grant in 2020, for their project on cluster headache, a neurovascular disease leading to extreme pain and for which there is currently no cure.
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Childhood environment and socioeconomic status affect cognitive ability and brain development during adolescence independently of genetic factors, researchers at Karolinska Institutet report in a new study published in the journal PNAS. The study demonstrates how important the family environment is, not just during early infancy but also throughout adolescence.
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In a new study, researchers from the University of Copenhagen and Karolinska Institutet have found neurons in the brain that control how mice turn left and right. The studdy was recently published in the journal Nature Neuroscience.
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KI Researchers present new insights on the ability of humans and other mammals to adapt to food availability and exposure to cold temperatures in a study recently published in eLife. The findings could enhance the development of new methods to treat metabolic disorders such as obesity or type 2 diabetes.
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Many nerve cells in the brain region hypothalamus have unexpected origins and go through complex development programs, where millions of neurons assemble into a precisely knit network by birth. That is according to a study by researchers at Karolinska Institutet in Sweden and the Medical University of Vienna published in the journal Nature. The findings may further our understanding of hormonal diseases and their origins, according to the researchers.
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Researchers at Karolinska Institutet and the University of North Carolina have mapped out the cell types behind various brain disorders. The findings are published in Nature Genetics and offer a roadmap for the development of new therapies to target neurological and psychiatric disorders. One interesting finding was that cells from the gut's nervous system are involved in Parkinson's disease, indicating that the disease may start there.
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Their researches on the lamprey brain has enabled researchers at Karolinska Institutet in Sweden to push the birth of the cortex back in time by some 300 million years to over 500 million years ago, providing new insights into brain evolution. The study is published in the scientific journal Nature Ecology & Evolution.
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An international team of scientists led by researchers at Karolinska Institutet has launched a comprehensive overview of all proteins expressed in the brain, published in the journal Science. The open-access database offers medical researchers an unprecedented resource to deepen their understanding of neurobiology and develop new, more effective therapies and diagnostics targeting psychiatric and neurological diseases.
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Researchers at Karolinska Institutet in Sweden and the University of Milan in Italy have identified a gene in human neurons that protects against the degeneration of motor neurons in the deadly diseases ALS and SMA. Gene therapy in animal models of these diseases was shown to protect against cell death and increase life expectancy. The study is published in the eminent journal Acta Neuropathologica.
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Researchers at Karolinska Institutet have mapped how different nerve cells in the brain area striatum process information to plan and execute our movements at just the right time and with the right vigour. The results, presented in the journal Cell Reports, show that different cell types in the striatum receive signals from completely different parts of the cerebral cortex and thus respond to different types of information.
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Researchers at Karolinska Institutet in Sweden have revealed a new principle of organisation which explains how locomotion is coordinated in vertebrates akin to an engine with three gears. The results are published in the scientific journal Neuron.
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Researchers at Karolinska Institutet have come one step closer toward understanding how the part of our brain that is central for decision-making and the development of addiction is organized on a molecular level. In mouse models and with methods used for mapping cell types and brain tissue, the researchers were able to visualize the organization of different opioid-islands in striatum. Their spatiomolecular map, now in Cell Reports, may further our understanding of the brain’s reward-system.
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Two KI researchers receive research project grant for international collaboration within rare diseases (EJP Rare diseases) from the Swedish Research Council.
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Four researchers at Karolinska Institutet have been granted a total of SEK 28 million in additional funding from the Knut and Alice Wallenberg Foundation (KAW). Two of these researchers are also promoted from Wallenberg Academy Fellows (WAF) to Wallenberg Scholars.
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Children who have received radiotherapy for a brain tumour can develop cognitive problems later in life. In their studies on mice, researchers at Karolinska Institutet have now shown that the drug lithium can help to reverse the damage caused long after it has occurred. The study is published in the journal Molecular Psychiatry and the researchers are now planning to test the treatment in clinical trials.
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StratNeuro awards a total of 1,6 MSEK to the following Collaborative Neuroscience Pilot Research Projects.
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Researcher at Karolinska Institutet have identified the first genetic link to CGRP signaling and cluster headache. CGRP is a neuropeptide that can trigger both migraines and cluster attacks and now several drugs are successfully launched that have CGRP or its receptor as their target. The results are published in a study in Cephalagia Report.
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Laura Crucianelli, researcher at the Department of Neuroscience, tells us about the "autonome sensory meridian response" (asmr) in podcast Medicinvetarna #24.
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The Swedish Magazine Fokus has ranked Henrik Ehrsson, from the Department of Neuroscience, as number 9 out of the 100 most prolific and quoted researchers in Sweden in the area of Medicine & Life Science.
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The Swedish Brain Foundation supports qualified research on the brain and other nervous systems, as well as diseases, injuries and disabilities throughout the nervous system. 98 out of 273 applications were granted funding this year.
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The Brain & Behavior Research Foundation's NARSAD Young Investigators Grant was awarded for the first time in 1987.
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It appears that when our nervous system is developing, only the most viable neurons survive, while immature neurons are weeded out and die. This is shown in a ground-breaking discovery by researchers at Karolinska Institutet in Sweden. The results indicate that the long-standing neurotrophic theory, which states that chance determines which cells will form the nervous system, needs to be revised.
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Researchers at Karolinska Institutet have studied the effects of exercise in a mouse model of premature ageing. The study with fellow researchers from Harvard Medical School, was recently published in the journal Aging Cell.
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Researchers at Karolinska Institutet have discovered a new sensory receptor organ that is able to detect painful mechanical damage, such as pricks and impacts. The discovery is being published in the scientific journal Science.
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Sten Linnarsson, professor of molecular systems biology at Karolinska Institutet, is trying to understand the development of the human brain. The Royal Swedish Academy of Sciences is now giving him this year’s Torsten Söderberg Academy Professorial Chair in Medicine for his work in achieving a detailed map of the human brain. The grant consists of SEK ten million over a five-year period.
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Gonçalo Castelo Branco, at Karolinska Institutet’s Department of Medical Biochemistry and Biophysics, is leading one of 38 projects that received a Chan Zuckerberg Initiative Seed Networks for the Human Cell Atlas grant. The project, investigating how oligodendrocytes can be different in the human brain and spinal cord, will be part of the Human Cell Atlas, a global consortium of scientists whose mission is to create comprehensive reference maps of all human cells.
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Memories of events, episodic memory, is better amongst women compared to men, researchers from Karolinska Institutet in Sweden have found in a new overview published in the scientific journal Psychological Bulletin. However, results vary depending on what is to be remembered.
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If a particular protein is missing during the fetal stage, no neurons develop that convey pain, temperature and itch, a study from Karolinska Institutet published in the journal Cell Reports shows. The discovery can eventually lead to new drugs for pain conditions.
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Researchers at Karolinska Institutet have traced the neurons that send projections to the medial prefrontal cortex in the mouse. The 3D location of the input neurons have been mapped throughout the brain.
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What happens in the brain when we feel discomfort? Researchers at Karolinska Institutet in Sweden are now one step closer to finding the answer. In a new study published in the journal Molecular Psychiatry they identify which pathways in the mouse brain control behaviour associated with aversion.
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Kaj Fried is the recipient of the Swedish Dental Association's International Prize 2018.
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Researchers at Karolinska Institutet have identified four types of neurons in the peripheral auditory system, three of which are new to science. The analysis of these cells can lead to new therapies for various kinds of hearing disorders, such as tinnitus and age-related hearing loss. The study is published in Nature Communications.
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Researchers from Karolinska Institutet and KTH Royal Institute of Technology have developed a new cell model for human brain helper cells known as astrocytes. The model could potentially be used in large-scale drug screening in the search for treatments for neurological diseases such as Alzheimer’s. The research is published in the scientific journal Stem Cell Reports.
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A study by researchers at Karolinska Institutet and the University of Copenhagen published in Nature provides new and important knowledge about how the brain controls locomotion. In research on mice, scientists have discovered that specific start cells in various locations in the brainstem control whether the mouse walks or runs. This research may lead to new treatments for diseases and injuries that adversely affect locomotion.
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KI webbförvaltning
09-06-2023