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With the progress in treatment for most cancer types, there is a growing interest to understand the overall impact of a cancer diagnosis throughout the remaining lifespan. In addition to conventional survival probabilities, estimating Life Expectancy following cancer diagnosis and Loss in Life Expectancy for cancer patients in comparison to if they did not have cancer provides valuable insights into the societal burden of cancer.
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Professor Paul Dickman at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet is awarded the prize Statistical Promotor of the year from the Swedish Statistical Society (Svenska statistikfrämjandet).
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On January 25, a method support day was organized by Clinicum to introduce researchers to the coordinated method support offered to researchers at KI and Region Stockholm. The meeting was held in the Sune Bergström Hall at Karolinska University Hospital.
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CLINICUM is part of the region-wide initiative that aims to strengthen the quality of clinical and translational research. In its entirety, CLINICUM consists of a central function and seven nodes which represent the care provider organizations in Region Stockholm and SLSO. The nodes' activities aim to offer scientific advice and to provide methodological support and guidance in the planning and execution of research projects.
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Audience: Medarbetare
Mikrobiologi, tumör- och cellbiologi, Medicinsk biokemi och biofysik, Medicinsk epidemiologi och biostatistik, Fysiologi och farmakologi, Neurovetenskap, Cell- och molekylärbiologi, Laboratoriemedicin, Klinisk vetenskap, intervention och teknik, Biovetenskaper och näringslära, Klinisk forskning och utbildning, Södersjukhuset, Kliniska vetenskaper, Danderyds sjukhus, Klinisk neurovetenskap
Karolinska Institutet has decided to award Johan Hartman and Mattias Rantalainen the 2023 Prize for Innovation and Utilization. They are rewarded for improving cancer diagnostics with innovative research and inspiring working methods.
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The Strategic Research Program in epidemiology (SFOepi) at Karolinska Institutet now announces funding for three different types of grants; Consolidator Grant for junior researchers, Junior Scholar Grants in Epidemiology or Biostatistics and small grants.
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Audience: Medarbetare
Medicinsk epidemiologi och biostatistik, Medicin, Solna, Global folkhälsa, Neurovetenskap
Predictions are becoming more and more a part of our lives, and they are becoming increasingly useful in medical science as the science evolves. Increased understanding of disease and its treatments allows us to use predictions based on predictive biomarker signatures to optimize treatment outcomes for increasingly specific subject groups.
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In a new thesis from Karolinska Institutet, the focus was on the use of multiomics data in the discovery of disease signatures.
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Competing risks and multi-state models allow us to study complex disease settings and answer composite research questions and should be used more widely in epidemiology.
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From byte to bench to bed side – addressing large and complex data sets in biomedicine
KI Network Medicine Alliance offers an advanced course in Network Medicine 19th-20th of October 2022
KI Network Medicine Alliance offers an advanced course in Network Medicine 19th-20th of October 2022
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In precision medicine, predicting the risk of an event during a specific period may help, for example, to identify patients that need early preventive treatment. Modern machine learning (ML) techniques are therefore ideal for building these predictions.
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Centre for Bioinformatics and Biostatistics arranges a networking event for researchers within bioinformatics and biostatistics Friday October 7th from 12 pm to 6 pm. The event takes place right after the conference Collaboration in Science 2022 and will be held in Neo building at Campus Flemingsberg. Register before September 9th!
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Audience: Medarbetare
Universitetstandvården, Biovetenskaper och näringslära, Medicin, Huddinge, Neurobiologi, vårdvetenskap och samhälle, Odontologi, Klinisk forskning och utbildning, Södersjukhuset, Klinisk vetenskap, intervention och teknik, Laboratoriemedicin
Are you interested in recruiting a bioinformatician or biostatistician? The centre for bioinformatics and biostatistics (CBB) is coordinating recruitments with possibility to make joint employments.
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Audience: Medarbetare
Mikrobiologi, tumör- och cellbiologi, Laboratoriemedicin, Klinisk vetenskap, intervention och teknik, Universitetstandvården, Biovetenskaper och näringslära, Medicin, Huddinge, Neurobiologi, vårdvetenskap och samhälle, Odontologi, Klinisk neurovetenskap, Kvinnors och barns hälsa, Onkologi-Patologi, Global folkhälsa, Molekylär medicin och kirurgi, Medicin, Solna, Kliniska vetenskaper, Danderyds sjukhus, Komparativ Medicin, Medicinsk biokemi och biofysik, Lärande, Informatik, Management och Etik, Fysiologi och farmakologi, INCF, Neurovetenskap, Cell- och molekylärbiologi
Enoch Yi-Tung Chen has been awarded the Swedish Society for Medical Statistics (Föreningen för Medicinsk Statistik, FMS) prize for best student project in the area of medical statistics during 2020. The prize, which includes an award of 5000 SEK, was announced at the FMS annual general meeting on 25 March 2021.
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Today's research is generating more and more big data, which means that the demand for bioinformatics and biostatistics is growing. Karolinska Institutet and Karolinska University Hospital are therefore establishing a new centre at Campus Flemingsberg that will offer expertise and networking opportunities for the preclinical and clinical research environment in the area.
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Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection (STI), with about 127 million new cases estimated annually worldwide. Since it is an asymptomatic infection, individuals may carry it for a long time and unknowingly transmit the infection to others.
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Dr Kung-Lee Liang, a pioneer in the field of biostatistics, gave a webinar via zoom with more than 100 attendees, including the President of KI, Ole Petter Ottersen. Dr. Liang spoke about how biostatistics contributed to medical science in the 20th century, and how we can rise to meet the current and future challenges in public health.
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The Charlson co-morbidity index (CCI) is a disease index that was originally created to predict short-term mortality but is increasingly used as a proxy for comorbidity burden, and is often used as a co-variate, for instance in regression models. There are currently several available versions of the CCI. The existence of multiple morbidity indices creates confusion, increases the risk of mistakes and requires individual researchers to spend considerable time examining included codes.
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One woman in eight develops breast cancer during her lifetime in the Western world and although mammography screening reduces mortality by early detection, approximately one fourth of the women who develop breast cancer are diagnosed within two years after a negative screen.
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Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is a malignant disease characterized by unique geographic distribution endemic to southern China, Southeast Asia, and the Middle East/North Africa. It is known that the interaction of Epstein-Barr Virus infection, environmental and lifestyle factors, and genetic susceptibility, contributes to NPC carcinogenesis.
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Shihua Sun has investigated the associations between attention-deficit/hyperactivity disorder (ADHD) and specific adverse outcomes including asthma and premature death. In his thesis, Shihua included four studies to clarify the magnitude and etiology of the associations, as well as potential effects from medication treatment that may prevent poor prognosis.
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In her thesis, Shadi Azam studied the association between established breast cancer risk factors with mammographic density change over time and mammographic microcalcifications by using data from the prospective KARMA cohort.
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Causal inference is important in medical research to help determine if treatments are beneficial and if natural exposures are harmful. In many settings, data collection makes causal inference difficult without making overly optimistic or idealistic assumptions. In a new article published in the Journal of the American Statistical Association, researchers at Karolinska Institutet develop new statistical methods to make causal inference possible in some settings without making such assumptions.
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In his thesis, Emilio Ugalde Morales uses a molecular epidemiology approach to investigate the association between risk factors and aggressive breast cancer defined by tumor characteristics, intrinsic subtypes, mode of detection, and survival.
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At the moment we live in an era where it is easier to generate data than to interpret them. The focus of Zheng Ning’s thesis is on methodology and analysis to exploit novel biological knowledge from published results of genome-wide association study (GWAS).
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Evaluating the genetic correlations across our phenotypes is of essential importance for understanding disease etiology and other potential causality. The new method – published in the journal Nature Genetics – vastly improves our power in estimating genetic correlations using the huge established resources from genome-wide association studies.
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The focus of Isabella Ekheden's thesis is on gastric and esophageal cancer – gastroesophageal cancers - that are some of the most fatal malignancies in the world. Understanding the cause of these diseases is key to interventions such as primary prevention and/or surveillance with the potential of lowering the disease burden.
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The focus of Johanna Sieurin's thesis was to investigate the relationship of personality and stress with subsequent risk of Parkinson’s disease (PD).
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Researchers at Karolinska Institutet show that different measures of psychopathology can be combined into a single factor, “p”, which predicts the patient’s prognosis and need of extra support. The general factor of psychopathology reflects the overall risk of adverse psychiatric outcomes with an accuracy equal to that currently used for intelligence, they report in a paper published in World Psychiatry.
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The objective of Peter's thesis is to develop and improve technologies for prostate cancer diagnostics and to acquire knowledge related to these technologies that directly translate to clinical utility.
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In her thesis, Ninoa Malki concludes that socioeconomic differences are associated with both incidence and mortality of cardiovascular disease in Sweden.
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On Friday December 18, Elisa Longinetti will defend her thesis "Amyotrophic lateral sclerosis and multiple sclerosis associated neuroinflammation: nationwide epidemiological studies on etiology, comorbidities, and treatment"
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On Friday December 6, 2019 Cecilia Radkiewicz defended her thesis "Sex differences in cancer risk and survival".
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On Tuesday December 10, Gabriel Isheden will defend his thesis Statistical models of breast cancer tumour growth and spread".
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Those with a family history of schizophrenia and men with lower IQ are more likely to struggle with treatment resistant schizophrenia than others with the mental disorder, according to a study by researchers at Karolinska Institutet in Sweden published in the journal Molecular Psychiatry. The researchers say the findings could be important in efforts to design novel drug treatments that improve cognition.
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Title: The comorbidity between attention-deficit/hyperactivity disorder and other neurodevelopmental disorders: aetiology, treatment and outcomes
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Title: Risk prediction in prostate cancer diagnostics : current challenges and improvements
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Title: Socioeconomic influences on late-life health and mortality : exploring genetic and environmental interplay
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A group of biostatistical scientists at the Department of Medical Epidemiology and Biostatistics (MEB) have been awarded a research environment grant of SEK 13 million from the Swedish Research Council for research into the development and application of statistical methods for register-based research.
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On Friday May 24 Elisabeth Dahlqwist will defend her thesis "Method developments for the attributable fraction in causal inference". Her opponent will be Professor Xavier de Luna from Handelshögskolan, Umeå universitet. Elisabeth's supervisors are Arvid Sjölander and Yudi Pawitan.
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