Breast cancer risk - determinants and influence of mammographic features
In her thesis, Shadi Azam studied the association between established breast cancer risk factors with mammographic density change over time and mammographic microcalcifications by using data from the prospective KARMA cohort.
Shadi first examined the association between established breast cancer risk factors with mammographic density change over time, and then went on to examine the association between annual mammographic density change and risk of breast cancer. The two last studies in the thesis investigated the association between established risk factors and microcalcification clusters and their asymmetry. Finally, Shadi looked at the association between number of microcalcification clusters, their asymmetry and the risk of overall and subtype specific breast cancer.
Among her findings, Shadi has identified novel determinants of mammographic density change and potential predictors of suspicious mammographic microcalcification clusters. Shadi also found that annual mammographic density change does not influence breast cancer risk, but the presence of suspicious microcalcification clusters was strongly associated with breast cancer risk.
On Dec 11, Shadi will defend her thesis “Determinants and influence of mammographic features on breast cancer risk”. Her opponent is Professor Graham Colditz from the Division of Public Health Sciences at Washington University in St. Louis, USA. Shadi's supervisors are Per Hall, Kamila Czene, Arvid Sjölander and Marike Gabrielson.
Location: Lecture hall Atrium, Nobels väg 12B, Karolinska Institutet, Solna
Read the thesis in KI’s open archive: https://openarchive.ki.se/xmlui/handle/10616/47391