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Researchers at Karolinska Institutet and SciLifeLab describe in a study published in Science how they have improved the ability of a protein to repair oxidative DNA damage and created a new protein function. Their innovative technique can lead to improved drugs for diseases involving oxidative stress, such as cancer, Alzheimer’s disease and lung diseases, but the researchers believe it has even greater potential.
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People with at least two of the diseases type 2 diabetes, heart disease or stroke have double the risk of developing dementia. Prevention of diabetes and cardiovascular disease could therefore be a strategy for reducing dementia risk, a study from Karolinska Institutet published in the journal Alzheimer’s & Dementia suggests.
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Researchers at Uppsala University and Karolinska Institutet are one step closer to explaining why COVID-19 patients have a substantially increased risk of blood clots. The study, published in Nature Immunology, shows that a gene variant in the innate immune system influences the risk for blood clots in the lungs of severely ill COVID-19 patients.
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Researchers at Karolinska Institutet, Germany’s Technical University of Munich (TUM) and AstraZeneca, among others, have identified a unique therapeutic approach with the potential to restore heart function following a heart attack. The new findings rely on so-called human ventricular progenitor (HVP) cells to promote novel heart tissue and reduce scarring after injury. This pre-clinical study is published in the journal Nature Cell Biology.
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Researchers at Karolinska Institutet have studied long-term morbidity and mortality in individuals who have had different models of biological heart valves implanted. The results, which show that there are considerable differences in performance depending on model group, are published in the journal JAMA Network Open.
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In a new study conducted by researchers at the group Vascular Surgery, Department of Molecular Medicine and Surgery, osteomodulin was identified as a novel biomarker for vascular calcification. The results of the study was recently published in the journal Clinical and Translational Medicine.
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Sweden is one of the few countries that have removed the dental health recommendation to give prophylactic antibiotics to people at a higher risk of infection of the heart valves, so-called infective endocarditis. Since the recommendation was removed in 2012, there has been no increase in this disease, a registry study from Karolinska Institutet published in the journal Clinical Infectious Diseases shows.
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In the largest funding round from the Swedish Heart-Lung Foundation (Hjärt-Lungfonden), researchers at Karolinska Institutet will share a total of 95,776,000 SEK. All in all, approximately 70 projects at KI will benefit from the grant.
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A new study is due to examine whether the post-infarction prognosis can be improved by treating the stomach ulcer bacterium helicobacter pylori. The study is to be led by Robin Hofmann, cardiologist and researcher at the Department of Clinical Research and Education, Stockholm South General (Söder) Hospital, Karolinska Institutet.
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Researchers at Karolinska Institutet and the Icahn School of Medicine at Mount Sinai in USA, have mapped how genes work together to cause cardiovascular disease. The study published in Nature Cardiovascular Research, suggests that that nearly 60 percent of the risk associated with coronary artery disease may be explained by regulatory gene networks.
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Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes. Researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institutet in Sweden have now studied one such protein, glutathione reductase, which protects against oxidative stress. They show that the risk for inflammatory bowel disease and vascular disease is increased several times in people carrying the Neanderthal variant.
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A receptor activated by substances formed from omega-3 fatty acids plays a vital role in preventing inflammation in blood vessels and reducing atherosclerosis, a new study from Karolinska Institutet published in The Journal of Clinical Investigation reports. The discovery can pave the way for new strategies for treating and preventing cardiovascular disease using omega-3 fatty acids.
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Endothelial cell dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. A new study from Karolinska Institutet show that an individual’s cardiovascular disease risk was linked to the levels of endothelial proteins found in the blood. The study was recently published in Arteriosclerosis, Thrombosis, and Vascular Biology, ATVB Journal.
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The risk of developing cardiovascular disease is strongly associated with the “bad” LDL cholesterol. A large study by scientists at Karolinska Institutet now shows that two proteins that transport cholesterol particles in the blood provide early and reliable risk information. The researchers advocate introducing new guidelines for detecting cardiac risk and say the results, published in PLOS Medicine, may pave the way for early treatment, which could help lower morbidity and fatality rates.
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Socioeconomic factors affect the risk of cardiovascular disease and the chances of recovery. New research from Karolinska Institutet interrogates the significance of socioeconomic factors for sudden out-of-hospital cardiac arrest. The study, which is published in Circulation, shows that education and income impact survival rates in both men and women.
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Altered function of the red blood cells leads to vascular damage in type 2 diabetes. Results from a new study in cells from patients with type 2 diabetes and mice show that this effect is caused by low levels of an important molecule in the red blood cells. The study by researchers at Karolinska Institutet in Sweden has been published in the journal Diabetes.
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Congratulations to five researchers at the Department of Molecular Medicine and Surgery who received funding from the Swedish Research Council within the field Medicine and Health at the dividend on October 28, 2021.
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Statins are a recommended and common intervention for preventing cardiovascular events by reducing levels of lipoprotein cholesterol in the blood. During the pandemic, it has been debated whether statins influence the risk of death from COVID-19. Researchers at Karolinska Institutet have now conducted the largest population study to date in the field. The study, which is published in PLOS Medicine, indicates that statin treatment slightly lowers COVID-19 mortality.
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Researchers at Karolinska Institutet have examined long-term outcomes in patients who received pacemaker implantations after transcatheter aortic valve replacement through their groin. The result showed no significant difference in mortality for the patients with pacemakers compared to those without. The study is published in the journal JACC: Cardiovascular Interventions.
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Postural hypotension, a drastic drop in blood pressure when standing up, is linked to an increased risk of dementia and accelerated progression from cognitive impairment to dementia, even in the absence of symptoms, for instance when feeling dizzy or faint. In a study published in the journal Hypertension, researchers from Karolinska Institutet show that postural hypotension could anticipate worse cognition in old age.
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Prolonged exposure to air pollution can be linked to an increased risk of stroke and coronary heart disease, even when levels are below the limits specified by the EU and WHO. This has been shown, among others, by researchers at Karolinska Institutet and Helmholtz Zentrum München in a large European study published in The Lancet Planetary Health.
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Screening for atrial fibrillation in 75- and 76-year-olds could reduce the risk of stroke, severe bleeding and death, according to a study at Karolinska Institutet in Sweden that has been published in the journal The Lancet.
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Researchers at Karolinska Institutet in Sweden can now report the results of a unique pilot project where drones were used to deliver defibrillators to real-life alerts of suspected cardiac arrest. The drones were dispatched in more than a fifth of the emergencies and arrived on target and ahead of the ambulance in most cases. The results are published in the European Heart Journal and presented today at the European Society of Cardiology congress.
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Researchers at Karolinska Institutet have identified eight primary factors that increase the risk of a common bleeding complication after heart attack. Some of these factors are already known, but using machine learning techniques, the researchers have found additional predictors, such as smoking, blood pressure and blood glucose.
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More knowledge is needed about risk factors for recurrent cardiovascular disease and myocardial infarction. In his thesis, doctor Joel Ohm at the Department of Medicine, Solna, Karolinska Institutet, describes how socio-economic factors have a major impact on secondary prevention efforts and prognosis. The results may have an impact on people who have survived myocardial infarction.
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Researchers at the Karolinska Institutet, University of Oxford and University of Copenhagen have shown that elevated levels of lipids known as ceramides can be associated with a ten-fold higher risk of death from cardiovascular disease. Treatment with liraglutide could keep the ceramide levels in check, compared with placebo. The results have been published in the Journal of the American College of Cardiology.
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In almost ten per cent of myocardial infarctions, no obvious cause in the coronary artery can be found. Some of the patients are diagnosed with broken-heart syndrome, while others are left without a diagnosis. A new study from Karolinska Institutet in Sweden suggests that early magnetic resonance (MR) imaging of the heart can greatly increase the rate of diagnosis. The study has been published in the journal JACC Cardiovascular Imaging.
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Patients with atherosclerosis today usually receive preventive treatment only after a heart attack or stroke because diagnostic methods that can identify individuals and atherosclerotic plaques with high-risk are lacking. In addition, the choice of treatment, both surgical and medical, is based on large patient studies and the possibilities for individualizing treatment are small.
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Good cholesterol, which is transported in HDLs (high-density lipoproteins), plays a key part in the prevention of atherosclerosis and thus the risk of cardiovascular disease. However, according to a new paper co-authored by researchers at Karolinska Institutet and published in the journal Circulation, the anti-inflammatory properties of HDLs could be an even better biomarker for future cardiovascular events.
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Men with stable coronary artery disease who are on Viagra due to impotence seem to live longer and have a lower risk of experiencing a new heart attack, a study from Karolinska Institutet in Sweden published in the Journal of the American College of Cardiology reports.
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Disorders of the cells’ energy supply can cause a number of serious diseases, but also seem to be connected to ageing. More research is needed on mitochondrial function to find future treatments. A new study involving researchers at Karolinska Institutet shows how an important molecule inside the mitochondria affects their function in mice and fruit flies. The study, which is published in Science Advances, adds valuable knowledge on formerly relatively unexplored protein modifications.
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The cause of the inflammatory lung disease sarcoidosis is unknown. In a new study, researchers at Karolinska Institutet have investigated whether a type of immune cell called a monocyte could be a key player in sarcoidosis pathogenesis and explain why some patients develop more severe and chronic disease than others. The study, which is published in The European Respiratory Journal, opens new possibilities for future diagnostic and therapeutic methods.
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Small studies have suggested that a group of medications called RAS inhibitors may be harmful in persons with advanced chronic kidney disease, and physicians therefore often stop the treatment in such patients. Researchers at Karolinska Institutet now show that although stopping the treatment is linked to a lower risk of requiring dialysis, it is also linked to a higher risk of cardiovascular events and death. The results are published in The Journal of the American Society of Nephrology.
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As life expectancies rise, so does the risk of dementia. Researchers at Karolinska Institutet have now studied how an active, non-smoking lifestyle can influence this correlation. The results, which are published in PLOS Medicine, suggest that good cardiovascular health gradually decreases the risk of dementia.
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DOAC (direct oral anticoagulant) pills are used in the treatment of atrial fibrillation by preventing blood clots. Even though blood clots are thought to contribute to complications from the new coronavirus infection, users of this class of drug do not seem to be protected against severe COVID-19, reports a large Swedish registry study from Karolinska Institutet published in The Journal of Internal Medicine.
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A new study from Karolinska Institutet shows that 1 in 5 patients admitted for acute myocardial infarction are infected with Helicobacter pylori and that it is possible to introduce screening for this bacterium in routine care. The results are published in the American Heart Journal. The researchers are now planning a large randomised trial to find out whether screening and treatment of the infection reduces the risk of stomach bleeding and improves cardiovascular outcomes in this patient group.
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Early-life events, such as the exposure to air pollutants, increases the risk of chronic lung disease in young adulthood, according to new results by researchers at Karolinska Institutet, Sweden, published in the European Respiratory Journal and Thorax. The studies add to the growing evidence that chronic lung disease in adulthood can be traced back to childhood.
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Researchers at Karolinska Institutet and Danderyd Hospital have studied the risk of additional myocardial infarctions and early death in severely obese patients who undergo metabolic surgery following a myocardial event. The registry study covering 1,018 individuals shows a lower risk of additional myocardial infarctions and improved survival that cannot be simply attributed to the loss of weight. The study is published in the journal Circulation.
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Thanks to new technology, researchers at the Clinical Physiology group, Department of Molecular Medicine and Surgery, Karolinska Institutet, have been able to show that females have higher myocardial perfusion, blood volume and extracellular volume in the heart compared to males. These findings were recently published in the journal Scientific Reports.
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João Ramos from the group Clinical Physiology at the Department of Molecular Medicine and Surgery will defend his thesis "Pulmonary hypertension and heart failure : physiological markers assessed by cardiovascular magnetic resonance" on May 8th, 2020. Main Supervisor is Martin Ugander.
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Physical exercise can act prophylactically for people with the metabolic syndrome and protect them against cardiovascular diseases, a new study from the Swedish School of Sport and Health Sciences, GIH, and Karolinska Institutet published in the European Journal of Preventive Cardiology reports. Even light physical exercise has been shown to have good prophylactic effects, for both women and men.
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People with celiac disease have increased risk of dying prematurely, despite increased awareness of the disease in recent years and better access to gluten-free food. This is according to a new study from Karolinska Institutet in Sweden and Columbia University in the U.S. published in the prestigious journal JAMA. Celiac disease was linked to increased risk of death from cardiovascular disease, cancer and respiratory disease.
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A new method of evaluating and prioritizing treatment for patients with suspected acute stroke, which has been used by the Stockholm health authority since 2017, has led to faster health interventions and better patient care, shows a new study from Karolinska Institutet published in the journal JAMA Neurology.
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People continuously exposed to air pollution are at increased risk of dementia, especially if they also suffer from cardiovascular diseases, according to a study at Karolinska Institutet in Sweden published in the journal JAMA Neurology. Therefore, patients with cardiovascular diseases who live in polluted environments may require additional support from care providers to prevent dementia, according to the researchers.
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In her thesis, Ninoa Malki concludes that socioeconomic differences are associated with both incidence and mortality of cardiovascular disease in Sweden.
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The financial burden on health systems would drastically increase if new European expert guidelines for cholesterol-lowering treatment were implemented, according to a new simulation study by researchers at Karolinska Institutet in Sweden, published in the European Heart Journal. The findings highlight an urgent need for cost-effectiveness analysis given the current cost of the proposed treatment for very high-risk patients, the researchers say.
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Researchers at Karolinska Institutet, together with colleagues from the EU-funded project HUMAN, recently published a study on a new animal model for studies of human lipoprotein metabolism and pharmacodynamics. The study is a result of the EU project HUMAN using a new animal model and new technologies to study aging and cardiometabolic diseases.
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There is a strong correlation between high blood pressure in patients in the emergency room and an increased risk of future cardiovascular disease, researchers from Karolinska Institutet report in a large registry study published in the journal Hypertension. Their conclusion is that blood-pressure measurements in the emergency room can be used as a tool for reducing morbidity and mortality rates through early preventive intervention.
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The new type of drugs for type 2 diabetes, the so-called SGLT2 inhibitors, are associated with a reduced risk of heart failure and death as well as of major cardiovascular events, a major Scandinavian registry study led from Karolinska Institutet reports in The BMJ.
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A novel study, published in the scientific journal Cardiovascular Research, identifies that maternal androgen excess increases the risk of cardiovascular disease in female animal offspring. The findings could have important clinical implications for women with polycystic ovary syndrome (PCOS) and may explain why women with PCOS and their daughters have increased risk of developing cardiovascular dysfunction in adult life.
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08-06-2022