News archive

Johan Erlandsson from the group Colorectal Surgery will defend his thesis "Preoperative radiotherapy in rectal cancer : aspects on fractionation and timing of surgery" on May 24, 2019. Main Supervisor is Anna Martling.

Björn Meister presented 2018's "Teachers of the Year" during the departmental coffee information meeting held on 21 May.

Cagla Sahin has received a Postdoctoral Fellowship for research abroad in bioscience and basic biomedicine from the Novo Nordisk Foundation

Researchers at Uppsala University and Karolinska Institutet in Sweden have studied the heritability of dog ownership using information from more than 35,000 twin pairs from the Swedish Twin Registry. The results, which are published in the journal Scientific Reports, indicate that an individual’s genetic make-up has a great influence on whether they choose to acquire a dog.

Currently, all donor documentation only exist in a Swedish and therefore the text is only written in Swedish. When the documentation has been updated we will happily welcome English-speaking bone marrow donors as well.

The Medical Management Centre (MMC) has been asked by The Public Health Agency of Sweden to evaluate a school-based first line-model.

By the time type 1 diabetes is diagnosed, most of the insulin-producing beta cells have already been destroyed. Now, using an innovative transplantation technique, researchers at Karolinska Institutet and University of Miami Miller School of Medicine have been able to intervene to save the beta cells in mice by discovering early signs of the disease. The study is published in Diabetologia, the scientific journal of the European Association for the Study of Diabetes (EASD).

Approximately one out of every ten people with hepatitis B are coinfected with hepatitis D, which is among the most serious liver conditions. Researchers at Karolinska Institutet and their German colleagues have described the impact of chronic hepatitis D on parts of the immune system. The study was published in the Journal of Hepatology.

This spring’s conferment ceremony at Karolinska Institutet was something of a record-breaker. As many as 157 new doctors of medical science received their hat and diploma in Stockholm City Hall before being given a cannon salute in celebration of their having earned the highest academic degree.

A research and innovation conference is currently in progress in Stellenbosch, South Africa, bringing together representatives of Swedish and South Africa universities. The main topic of the week-long conference, which opened on 6 May under the STINT-financed South Africa–Sweden University Forum (SASUF) project, is Agenda 2030.

On Friday May 24 Elisabeth Dahlqwist will defend her thesis "Method developments for the attributable fraction in causal inference". Her opponent will be Professor Xavier de Luna from Handelshögskolan, Umeå universitet. Elisabeth's supervisors are Arvid Sjölander and Yudi Pawitan.

Number-of-days-at-home within 30 days after surgery (DAH30) is a patient-centred outcome metrics that integrates length of hospital stay and any readmission or death within 30 days after a surgical procedure.

Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study from Karolinska Institutet shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced. The results open the possibility for new treatment strategies for advanced cancers. The study is published in Nature Communications.

Is it okay to constantly be interrupted at work? Of course not, was Lena Berg’s answer, until she met her polar opposite.

Carina Strell and colleagues in the Arne Östman research group has published an article in Journal of the National Cancer Institute investigating mechanisms controlling fibroblast functions in ductal breast carcinoma in situ (DCIS).

In the present study Elin Sjöberg and colleagues in the Arne Östman research group have identified that cancer associated fibroblast (CAF)-produced CXCL14 re-activates a developmental program that promote migration and invasion of cancer cells, leading to increased formation of lung metastasis in mice. They also identified a novel CXCL14-signaling component, ACKR2, which is important for the tumor-promoting effects of CXCL14.

Subtle changes in protein composition by a process called ‘citrullination’ are thought to be involved in causing several diseases, including multiple sclerosis. Researchers from Karolinska Institutet now show in the journal Cell Reports that the enzyme PAD2, the main protein responsible for this process in the brain, also plays an important role in the normal development of a subset of brain cells, known as oligodendrocytes, and in their function in stimulating neuronal communication.

Pregnant women with type 1 diabetes are at increased risk of delivering their baby prematurely. The risk increases as blood sugar levels rise, however women who maintain the recommended levels also risk giving birth prematurely. These are the findings from researchers at Karolinska Institutet and the Sahlgrenska Academy in Sweden, published in Annals of Internal Medicine.

The picture above shows a tuberculosis (TB) infection in a mouse lung, in which immune cells form a granuloma around the bacteria. The different symbols represent working copies of active genes, called messenger RNA, which are different in the granuloma centre in comparison to the surrounding cells.

An initial gene analysis may yield better outcomes when patients are treated with the antipsychotic drugs risperidone and aripiprazole. A novel study shows how the activity of a specific enzyme, which metabolises the two drugs, affects the individual dose that should be given for optimal treatment. The study is published in The Lancet Psychiatry and has been conducted by researchers at Karolinska Institutet, in collaboration with the Diakonhjemmet Hospital in Oslo, Norway.

In a new study, led by Professor Janne Lehtiö (SciLifeLab/Karolinska Institutet), researchers from SciLifeLab, University of Oslo, and MD Anderson Cancer Center have generated a detailed map of protein levels in breast tumors. The proteome complements the previously known DNA and RNA picture of breast cancer and sheds light on how different mutations give rise to changes on the protein level.

Hi there Linda P. Sturesson, PhD student at the Department of Learning, Informatics, Management and Ethics. Your new book "Diskvalificering av det positiva" (Disqualification of the positive) was released on April 11th.

Researchers from Karolinska Institutet have found a protein that is a critical regulator in the development of fatty liver disease in mice, according to a study published in the journal Nature Communications. Analysis of liver biopsies of patients indicate that the identified mechanisms may help explain the diverse susceptibility of patients to develop more severe stages of fatty liver disease.

Professor Janne Lehtiö and his colleagues at the department of Oncology-Pathology have together with Kajsa Paulsson and her group at Lund University published an article in Nature Communications where they have investigated the two most common subtypes of pediatric acute lymphoblastic leukemia (ALL) using in depth proteomics and next generation sequencing techniques.

Researchers at Karolinska Institutet present a publicly available resource that can accelerate the use of so-called FISH techniques for studying how the genome is spatially organised in the cell nucleus. The new platform, which enables more cost-effective analyses for both research and diagnostic labs, is described in the scientific journal Nature Communications.