Proteome picture of breast cancer
In a new study, led by Professor Janne Lehtiö (SciLifeLab/Karolinska Institutet), researchers from SciLifeLab, University of Oslo, and MD Anderson Cancer Center have generated a detailed map of protein levels in breast tumors. The proteome complements the previously known DNA and RNA picture of breast cancer and sheds light on how different mutations give rise to changes on the protein level.
In the study, almost 14 000 proteins from the tumor tissue were quantified. The result confirms known tumor sub types, but further subdivide these, suggesting that the current classification is incomplete. Investigating copy number effects, identified buffering at the protein level. Proteins from part of the genome, not thought to be translated, was also identified. These novel proteins can function as tumor specific antigens and be used in immunotherapy treatment.
To help other researchers the authors shared their data in a user friendly data portal (www.breastcancerlandscape.org) with analysis tools.
Publication
Breast cancer quantitative proteome and proteogenomic landscape.
Johansson H, Socciarelli F, Vacanti N, Haugen M, Zhu Y, Siavelis I, et al
Nat Commun 2019 04;10(1):1600