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In cannabis trials against pain, people who take placebos report feeling largely the same level of pain relief as those who consume the active cannabinoid substance. Still, these studies receive significant media coverage regardless of the clinical outcome, report researchers from Karolinska Institutet in a study published in JAMA Network Open.
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The StratNeuro Bridging Grant at the consolidator level is a funding initiative where StratNeuro awards up to two consolidator level grants to support outstanding researchers in the field of neuroscience at Karolinska Institutet.
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How do people decide whether to intervene and help others in danger? Researchers at Karolinska Institutet now show that the same system in the brain that enables us to avoid danger is also activated during selfless, helping behaviour. The results are published in the scientific journal eLife.
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The multiple sclerosis (MS) research consortium at Karolinska institutet is
further strengthened by the recruitment of the distinguished MS scientist, Roland
Martin.
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On October 4, 2022, research group leader Niaz Ahmed was employed as an adjunct professor at the Department of Clinical Neuroscience (CNS), the Division of Neuro.
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StratNeuro has awarded SEK 2,000,000 in start-up grants to 4 international researchers who are establishing their groups at Karolinska Institutet, after receiving faculty-funded Assistant Professor (“biträdande lekor”) positions.
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Distinct neuron types in the auditory organ are necessary for encoding different features of sound and relaying them to the brain. Researchers at Karolinska Institutet provide evidence of an early, neuronal activity-independent, emergence of the different subtypes of auditory neurons, prior to birth in mice. The findings have recently been published in Nature Communications.
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On 18-20 May 18 2022 we were excited to finally host the annual StratNeuro retreat at Runö in Åkersberga. This year's retreat was somewhat special. Many were eager to meet again, and the organisers worked hard to make this meeting a productive and memorable one.
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Researchers at Karolinska Institutet in Sweden might have found an explanation for why people with self-injury behaviour generally feel less pain than others. The key seems to be a more effective pain-modulation system, a discovery that can benefit people seeking help for their self-harm. The findings are published in the journal Molecular Psychiatry.
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Currently available therapies to treat multiple sclerosis (MS) lack precision and can lead to serious side effects. Researchers at KI have now developed a method for identifying the immune cells involved in autoimmune diseases, and have identified four new target molecules of potential significance for future personalised treatment of MS. The results, which are published in Science Advances, have been obtained in collaboration with KTH Royal Institute of Technology and Region Stockholm.
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What smells we like or dislike is primarily determined by the structure of the particular odour molecule. A collaborative study involving researchers from Karolinska Institutet, Sweden, and the University of Oxford, UK, shows that people share odour preferences regardless of cultural background. The study is published in the journal Current Biology.
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StratNeuro has awarded SEK 1,000,000 in start-up grant 2022 to Enric Llorens, Arvid Guterstam and Jeroen Goos.
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The StratNeuro board has reviewed the neuroscience submissions to the SLL call “Kliniska Forskare” (2020) and decided to support Mikael Tiger with SEK 500,000, for his project entitled "Optimized treatment for depression: mechanisms of action and response markers and antidepressive effect versus side effects".
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The bridging grant is a funding initiative where StratNeuro, and other strategic research areas (SFOs) at KI, award funding to promising researchers with outstanding scientific merits, giving them the opportunity to consolidate their research.
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There has to date been no reliable objective method of diagnosing tinnitus. Researchers from Karolinska Institutet now show that brainstem audiometry can be used to measure changes in the brain in people with constant tinnitus. The study has been published in The Journal of Clinical Investigation.
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There is a correlation between the ability to understand complex syntax and the fine-motor skills required for manipulating tools. In a new study published in the journal Science, researchers at Karolinska Institutet and the French research institute Inserm show that the same cluster of neurons in the brain are involved in both skills. The study also shows that training with a tool improves language skills and vice versa.
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It remains a central challenge in psychiatry to reliably judge whether a patient will respond to treatment. In a new study published in the journal Biological Psychiatry, researchers from Karolinska Institutet in Sweden and the Max Planck Institute for Human Development in Germany show that moment-to-moment fluctuations in brain activity can reliably predict whether patients with social anxiety disorder will be receptive to cognitive behavioural therapy (CBT).
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The ability to detect and react to the smell of a potential threat is a precondition of our and other mammals’ survival. Using a novel technique, researchers at Karolinska Institutet have been able to study what happens in the brain when the central nervous system judges a smell to represent danger. The study, which is published in PNAS, indicates that negative smells associated with unpleasantness or unease are processed earlier than positive smells and trigger a physical avoidance response.
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Researchers at Karolinska Institutet in Sweden have identified a protein that improves muscular metabolism, motor coordination and exercise performance in mice. The findings, published in Cell Metabolism, could be of therapeutic value for patients with muscle and neurological diseases, such as ALS.
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Both humans and other animals learn quickly about dangers in their environment by observing the behavior of other individuals. Researchers at Karolinska Institutet now show that both rats and humans can use such social information to reactivate memories about threats that have been previously acquired through their own experiences.
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Professor Per Svenningsson at Karolinska Institutet receives funding for a five-year research project of 38 million SEK from Nordstjernan Holding AB and the Axel Johnson Group. The investment goes to fundamental research on the onset of Parkinson's disease and to clinical studies to improve treatment and slow down the course of the disease.
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Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet published in The Lancet Psychiatry.
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Researchers at Karolinska Institutet and UCL have identified a general factor called ‘decision acuity’ that affects young people's decision-making ability, independent of IQ, and is associated with good social functioning. The results have been published in the journal Neuron.
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Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells. A brain imaging study at Karolinska Institutet now shows that the average level of the serotonin transporter increased in a group of 17 individuals who recovered from depression after cognitive behavioural therapy. The results are published in the journal Translational Psychiatry.
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StratNeuro has awarded SEK 1,000,000 in start-up grant to Kristoffer Månsson, who was granted a 2020 faculty-funded Assistant Professor (biträdande lektor) position.
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Cholinesterase inhibitors are a group of drugs recommended for the treatment of Alzheimer’s disease, but their effects on cognition have been debated and few studies have investigated their long-term effects. A new study involving researchers from Karolinska Institutet and published in the journal Neurology shows persisting cognitive benefits and reduced mortality for up to five years after diagnosis.
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A large brain imaging study involving researchers at Karolinska Institutet demonstrates that same-sex sexual behaviour-related differences in the brain exist. Patterns in the brain that differentiate between men and women were less pronounced in non-heterosexual individuals, and some of the brain differences could be linked to a genetic predisposition for non-heterosexuality. The study is published in the scientific journal Human Brain Mapping.
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The StratNeuro board has reviewed the neuroscience submissions to the SLL call “kliniska forskare” (2020) and decided to support the two researchers at Karolinska Institutet with SEK 500,000 each.
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StratNeuro has awarded SEK 1,000,000 in start-up grant to Maya Ketzef receiving a 2020 VR 'starting grant and Sara Garcia-Ptacek receiving a 2020 facutly-funded Assistant Professor position.
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Individuals with high ADHD-traits that do not meet the criteria for a diagnosis are less able to perform tasks involving attentional regulation or emotional control after a sleepless night than individuals with low ADHD-traits, a new study from Karolinska Institutet published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging reports.
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Researchers at KI have received SEK 36,800,000 from the Swedish Research Council’s consolidator grant 2020. In total, SEK 217 million was distributed to 20 universities.
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Researchers at Karolinska Institutet have studied the incidence and regional distribution of Alzheimer’s disease biomarkers in the brains of people with Down’s syndrome. The results can bring new possibilities for earlier diagnosis and preventive treatment of dementia. The study is published in Molecular Neurodegeneration.
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People with autism spectrum disorder have lower levels of a protein that regulates the amount of serotonin in the brain, a paper from Karolinska Institutet in Sweden published in the journal Molecular Psychiatry reports. For their study, the researchers used a molecular brain imaging technique to compare people with and without autism; their results offer hope of finding a drug that can alleviate the symptoms.
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Three researchers at Karolinska Institutet have been awarded the 2020 ERC Starting Grant: Niklas Björkström, Janina Seubert and Nils Landegren. Their projects concern resident organ-specific immune cells, the cognitive mechanisms behind our preference of certain foods, and sex-differences in the human immune system and the risk of autoimmune disease. In all, the European Research Council will support 436 early-career researchers with this prestigious grant.
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Karolinska Institutet and St. Erik Eye Hospital have entered into a collaboration with Novo Nordisk A/S to develop a new treatment for age-related macular degeneration. Novo Nordisk A/S will provide support and SEK 48 million in funding to enable a phase 1 clinical trial where new retinal cells generated from embryonic stem cells will be transplanted into patients. The aim is to develop a completely new cell therapy for this common but currently incurable eye disease.
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Being socially active generally increases your chances of getting a good night’s sleep. But if you are active late into the evening, it reduces the number of hours you sleep – and can also affect your social life. This is according to a new study from Stockholm University and Karolinska Institutet published in the scientific journal PNAS.
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Researchers at Karolinska Institutet have imaged tau protein in the brains of living patients with Alzheimer’s disease. The amount and spread of tau proved a predictor of future memory loss. Brain imaging for measuring tau can be useful both for improving diagnosis and for developing more effective treatments, say the researchers. The study is published in the journal Molecular Psychiatry.
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The StratNeuro board has reviewed the neuroscience submissions to the SLL call “högre kliniska forskare” (2019 and 2020) and decided to support the following researchers with SEK 500,000 each.
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The anaesthetic drug ketamine has been shown, in low doses, to have a rapid effect on difficult-to-treat depression. Researchers at Karolinska Institutet now report that they have identified a key target for the drug: specific serotonin receptors in the brain. Their findings, which are published in Translational Psychiatry, give hope of new, effective antidepressants.
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Childhood environment and socioeconomic status affect cognitive ability and brain development during adolescence independently of genetic factors, researchers at Karolinska Institutet report in a new study published in the journal PNAS. The study demonstrates how important the family environment is, not just during early infancy but also throughout adolescence.
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An international team of scientists led by researchers at Karolinska Institutet has launched a comprehensive overview of all proteins expressed in the brain, published in the journal Science. The open-access database offers medical researchers an unprecedented resource to deepen their understanding of neurobiology and develop new, more effective therapies and diagnostics targeting psychiatric and neurological diseases.
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Researchers at Karolinska Institutet have come one step closer toward understanding how the part of our brain that is central for decision-making and the development of addiction is organized on a molecular level. In mouse models and with methods used for mapping cell types and brain tissue, the researchers were able to visualize the organization of different opioid-islands in striatum. Their spatiomolecular map, now in Cell Reports, may further our understanding of the brain’s reward-system.
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Researchers at Karolinska Institutet have developed an online Cognitive Behavioural Therapy (CBT) programme for the difficult-to-treat pain syndrome fibromyalgia. In her doctoral thesis, Maria Hedman-Lagerlöf shows that patients who receive the treatment experience fewer symptoms and enjoy better quality of life.
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Researchers at Karolinska Institutet have developed a new method to separate between two different types of a common herpes virus (HHV-6) that has been linked to multiple sclerosis. By analyzing antibodies in the blood against the most divergent proteins of herpesvirus 6A and 6B, the researchers were able to show that MS-patients carry the herpesvirus 6A to a greater extent than healthy individuals. The findings, published in Frontiers in Immunology, point to a role for HHV-6A in MS development.
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Those with a family history of schizophrenia and men with lower IQ are more likely to struggle with treatment resistant schizophrenia than others with the mental disorder, according to a study by researchers at Karolinska Institutet in Sweden published in the journal Molecular Psychiatry. The researchers say the findings could be important in efforts to design novel drug treatments that improve cognition.
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Children who suffer mild brain injury due to oxygen deprivation at birth normally do not receive cooling therapy to reduce the risk of permanent damage. Now, researchers at Karolinska Institutet and University College Cork report that these children have significantly impaired cognitive outcomes at 2-3 years of age and therefore should be included in future clinical trials of neuroprotective therapies. The study is published in JAMA Pediatrics.
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People with multiple sclerosis (MS) who also have depression are more likely to suffer debilitating symptoms early than people with MS who are not depressed, according to a study at Karolinska Institutet in Sweden that is published in the journal Neurology. The findings highlight the need for early recognition and treatment of depressive symptoms in patients with MS.
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Correction: The article “Reduction in Mental Health Treatment Utilization Among Transgender Individuals After Gender-Affirming Surgeries: A Total Population Study,” published in The American Journal of Psychiatry on Oct. 4, 2019, has been corrected following a review of the statistical methodology and some of its conclusions.
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26 September, 2019
Major genome map of MS
Researchers at Karolinska Institutet have taken part in the largest study to date on the genetic risk factors for multiple sclerosis (MS). The study, which is published today in the journal Science, corroborates earlier studies and provides new clues as to what causes this neurological disease. The resulting map will prove a vital resource for future researchers and could one day lead to new, more potent drugs.
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The timing of anemia—a common condition in late pregnancy—can make a big difference for the developing fetus, according to research at Karolinska Institutet published in JAMA Psychiatry. The researchers found a link between early anemia and increased risk of autism, ADHD and intellectual disability in the child. Anemia discovered toward the end of pregnancy did not have the same correlation. The findings underscore the importance of early screening for iron status and nutritional counselling.
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