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Researchers from Karolinska Institutet discovered that the retinoblastoma associated protein RB and the mitochondrial ribosomal protein S18-2 (MRPS18-2) play the essential roles in homeostasis of cell stemness. Rb1-/- mouse primary cells expressing both, S18-2 and RB exhibited a stem cell phenotype. Downregulation of S18-2 and RB in human mesenchymal stem cells resulted in decreased expression of stem cell-related genes. Loss of the S18-2 protein resulted in embryonic lethality in zebrafish.
The risk of developing more than one skin melanoma over a ten-year period has seen a ten-fold increase in Sweden since the 1960s, a new study by researchers at Karolinska Institutet and Lund University published in The Journal of the National Cancer Institute reports. The researchers suspect that the increase is due to a change in holiday customs with more active sunbathing and overseas trips to southern climes.
Cell surface receptors are essential for the communication of human cells. Simon Elsässer’s lab has developed a method to study these proteins on living cells. With very subtle alterations the method allows to label receptors with two different fluorescent probes in defined positions, as the authors show in Cell Reports. This can give detailed insights in how the conformation of a receptor changes as a result of for example drug binding, in the natural setting of the cell membrane.
2020-06-24 09:00
The disturbances have mostly been solved. Some systems might still be affected.

Troubleshooting continues.

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We're currently experiencing major disturbances with the KI network which affect most of KI's services.

Troubleshooting is underway.
Decades-long endurance training alters the activity of genes in human skeletal muscle that are important for metabolic health. This is according to a new study published in the journal Cell Reports by researchers at Karolinska Institutet in Sweden and the University of San Diego in the U.S. Sex differences found in untrained individuals were also dramatically reduced with long-term training. The results may have implications for metabolic disease prevention.
The StratNeuro board has reviewed the neuroscience submissions to the SLL call “högre kliniska forskare” (2019 and 2020) and decided to support the following researchers with SEK 500,000 each.
StratNeuro has awarded SEK 1,000,000 in start-up grant to each of the following KI recipients of a 2019 VR ‘starting grant’.
StratNeuro received 37 submissions from across 9 departments for the postdoctoral research grants. After evaluation from 10 external invited reviewers, we are happy to announce that StratNeuro will fund the 15 top ranked submissions (shown below in alphabetical order).
In a study in mice, researchers at Karolinska Institutet have discovered a new potential therapeutic approach to facilitate neurological recovery in people with diabetes suffering from stroke. The treatment strategy is based on the chronic normalization of hyperglycemia after stroke. The scientists hope that these new results, presented in the scientific journal Diabetes, open the possibility to improve the current rehabilitative strategies against stroke in the diabetic population.
Utbildningsradion (the Swedish Educational Broadcasting Company) dedicates two half-hour television episodes to Jonas F Ludvigsson, researcher and pediatrician. In the first episode, Ludvigsson talks about how he repeatedly failed to write up his thesis. In the second episode, he talks about what it is like to work with seriously ill and injured children.
Researchers at Karolinska Institutet have investigated the efficacy and safety of different approaches to ovarian stimulation of women with breast cancer in a multicenter study. Results of this large prospective multicenter study support the premise that current approaches to fertility preservation with ovarian stimulation in women with breast cancer are both safe and efficacious.
Availability for the management and administration at the Department of Global Public Health during the summer of 2020.
Patients with low income have a higher risk of death following surgery for lung cancer compared with patients with high income. The association remains even after taking prevalence of common comorbidities, and other factors that are known to influence the risk of death, into account. This is according to a study published in the journal Thorax by researchers at Karolinska Institutet in Sweden.
We can now conclude that the COVID-19 related morbidity among children during the two most intense months of SARS-CoV-2 transmission in Stockholm was low, despite the strategy to keep preschools and primary schools open.
Professor Janne Johansson has been appointed Head of the Department of Biosciences and Nutrition, starting on September 1st, 2020 until August 31st, 2025.
Researchers at the Karolinska Institutet have discovered a new interaction between two proteins that reduce the risk of DNA damage and cellular cancer development. The findings on the proteins RTEL1 and Poldip3 are published in the journal Genes & Development.
Anders Jahre´s Award to younger researchers goes to Niklas Björkström, Center for Infectious Medicine, for his discoveries in how NK cells develop and function in physiological and pathological situations.
MedTechLabs is now seeking an operational coordinator 50% who will be a link between the centre and the various departments of Karolinska University Hospital.
Karolinska Institutet (KI) has been awarded funding from the Swedish Insitute (SI) for two training programmes amounting to a total of four million SEK within the framework of the Swedish Institute’s (SI) Public Sector Innovation Programme. The programmes will run 2020-2021.
As a consequence of the ongoing pandemic and spread of COVID-19, and in line with the recommendations of Swedish authorities and KI, the administrative staff at the department will continue to mainly work remotely. Here are a few updates from the administration at NEURO regarding Summer 2020.
Week 28 – 29: Anna Bergström
Week 30: Irene Jensen
Week 31 – 32: Agneta Åkesson
Tips from KI Grants Office about current calls.
During the summer, the reception in Biomedicum will have changed opening hours.
While most countries have national policies in place, effective coverage is very low and often exclude those who have the greatest need. There are often several prominent barriers, especially for those outside the formal workforce who are affected by illnesses such as COVID-19, according to a newly published article by researchers at Karolinska Institutet and the SPARKS Network.
MedTechLabs is now seeking a deputy director who will be responsible for the centre’s educational activities, including coordinating efforts associated with the MTL educational videos and organising educational seminars, webinars, etc.
Will you be working during the summer months and have a little bit more time on your hands than usually? You can start preparing for some changes within IT that are going to take place in the autumn term.
The minutes from the IMM board meeting on May 11 can be found in the folder P: IMM_Information/Protokoll
Between the 18th July-2nd of August the support for digital teaching and examinations is not staffed.
Kristina Johnell and the three vice heads of department will be responsible during different weeks this summer.
Researchers from Karolinska Institutet and Nanyang Technological University (NTU) in Singapore have found that the claustrum is organised into functional connectivity modules rather than a hub-like structure, which up until now, was the prevailing idea. The study was recently published in Current Biology.
Congratulations to Andrea Carmine Belin and Caroline Ran, researchers at the Department of Neuroscience, who have received The Swedish Brain Foundation's Research Grant in 2020, for their project on cluster headache, a neurovascular disease leading to extreme pain and for which there is currently no cure.
Staff and students at the Department of Global Public Health, as well as master student, share how the pandemic has affected their day-to-day routines and their hopes for the fall term.
Tips from KI Grants Office about current calls.
Researchers at Karolinska Institutet have discovered that excessive degradation of the power plants of our cells plays an important role in the onset of mitochondrial disease in children. These inherited metabolic disorders can have severe consequences such as brain dysfunction and neurological impairment. The study is published in EMBO Molecular Medicine.
Development of Courses at Basic, Advanced and Doctoral levels
Professor Johan von Schreeb, Head of the team Centre for Research on Health Care in Disasters at GPH, the team that has been hard at work for several months with developing online training for health care staff.
A drug against rheumatoid arthritis called baricitinib could potentially be repurposed to treat patients with COVID-19, according to a study conducted by an international research team including researchers at Karolinska Institutet in Sweden. The findings, published in the journal EMBO Molecular Medicine, represent an example of how artificial intelligence (AI)-algorithms could help identify existing drugs as potential therapies against as new illnesses.
The Department of Physiology and Pharmacology (FyFa) has several representants in various decision-making and advisory bodies at Karolinska Institutet. With this comes the opportunity to influence and develop, among other things, KI's educational, research and collaborative activities.
Researchers at Karolinska Institutet uncover surprising features of mitochondrial protein synthesis. The study, published in Nature Communications, sheds light on the fundamental mechanisms used by the cell’s power plant.
Good health policies have the potential to positively impact people’s lives and reduce inequalities. Even though the aim is to base health policies on science, research evidence is only one of many factors impacting their development and implementation. Politics, culture, money and available health care staff often shape health policies and how they are put into practice.
The capacity of a stem cell population to generate several distinct cell types in a temporally defined manner is fundamental to both organ development and homeostasis. To achieve this, stem cells must carefully balance self-renewal and commitment to cellular differentiation, but how this is regulated at the genetic level has remained unclear.
Researchers at Karolinska Institutet are part of a consortium granted almost 66 million euros (690 million Swedish kronor) by the european Innovative Medicines Initiative (IMI) and other parties. The funds will be used to develop, test and facilitate access to chemical substances and other research tools that could pave the way for new drug targets and treatments of diseases within areas such as inflammation and cancer.
The School of Health Innovation is the first and only Nordic initiative to offer courses in innovation as an extension of the academic subjects health sciences and life sciences. The school was founded by Karolinska Institutet, KI, Oslo University, UiO, and Norwegian University of Science and Technology NTNU. The University of Copenhagen will be joining the initiative shortly and the Novo Nordisk Foundation announces its financial support with over SEK 10 million over the next three years.
The disruptive noice in Ljusgården is due to a malfunction in the sound system. IT is investigating.
KW
KI webbteam
2020-06-08