News archive

Research on the role of diet in the development of type 1 diabetes is generally of low evidence, but there are some high-quality studies indicating that longer breastfeeding and later introduction to gluten may reduce the risk of disease. That is according to a systematic review and meta-analysis of available research on foods that may be linked to the risk of developing the type 1 diabetes in childhood. The study by researchers at Karolinska Institutet is published in the journal EBioMedicine.

The early development of the immune system, antibiotics in dentistry and strengthened medical pedagogy. These are some of the research areas that Karolinska Institutet's new professors are interested in. On 14 October 2021, the annual inauguration ceremony was held in Aula Medica where 18 new professors were installed, and 12 adjunct professors and 2 visiting professors were welcomed to their new positions at the university.

Paul Ackermann is researching why problems often arise in the healing-process in tendons, ligaments, and other connective tissue in the locomotor system. His work can give rise to new therapies designed to help the injury to heal properly and prevent chronic pain and blood clots.

Less exercise and less rehab are the experiences reported by persons with Parkinson’s disease in a new study from Karolinska Institutet. The study sheds light on the situation during the first wave of the COVID-19 pandemic. According to Erika Franzén, professor and physiotherapist, especially women over 70 can be viewed as a risk group for reduced physical activity.

Statins are a recommended and common intervention for preventing cardiovascular events by reducing levels of lipoprotein cholesterol in the blood. During the pandemic, it has been debated whether statins influence the risk of death from COVID-19. Researchers at Karolinska Institutet have now conducted the largest population study to date in the field. The study, which is published in PLOS Medicine, indicates that statin treatment slightly lowers COVID-19 mortality.

Researchers from KTH Royal Institute of Technology, Karolinska Institutet and Karolinska University Hospital have developed a new kind of antibiotic-free protection for wounds that kills drug-resistant bacteria and induces the body’s own immune responses to fight infections. The technology is presented in the Journal of the American Chemical Society and could be an important tool in the fight against multidrug-resistant bacteria.

It remains a central challenge in psychiatry to reliably judge whether a patient will respond to treatment. In a new study published in the journal Biological Psychiatry, researchers from Karolinska Institutet in Sweden and the Max Planck Institute for Human Development in Germany show that moment-to-moment fluctuations in brain activity can reliably predict whether patients with social anxiety disorder will be receptive to cognitive behavioural therapy (CBT).

The ability to detect and react to the smell of a potential threat is a precondition of our and other mammals’ survival. Using a novel technique, researchers at Karolinska Institutet have been able to study what happens in the brain when the central nervous system judges a smell to represent danger. The study, which is published in PNAS, indicates that negative smells associated with unpleasantness or unease are processed earlier than positive smells and trigger a physical avoidance response.

Researchers at the Aging Research Center (ARC) have been awarded several substantial grants from Forte's annual open call for proposals. Out of the 32 projects, programmes and networks that received funding at KI, five were awarded to ARC. The aim is to analyse enabling and contributing to an in-depth knowledge in research areas or issues.

Petter Brodin is a paediatrician and is researching the early deve- lopment of the immune system. His research can contribute to the development of new and more effective treatments, including for the prevention of autoimmune diseases, asthma and allergies.

Torkel Brismar researches how X-ray and other medical images can be translated into quantitative data for use in the assessment of diseases such as cancer and osteoporosis as an aid for doctors in their decision-making.

With a tight student budget, buying course literature can feel tough. The student association STRÄVA works, among other things, to ensure that everyone has access to course literature, and they are involved in the project KI students' book donation.

Marie Klingberg Allvin’s work involves strengthening midwifery, often in low-resource countries, in order to give women access to better healthcare. She believes in the integration of research and education – something that is also included in her new professorship.

Lymphoma is a common cancer that exists in many forms. Karin Ekström Smedby is mapping the epidemiology of the disease, from risk factors to survival. She is also researching new biomarkers that can lead to more efficacious treatment.

Olof Stephansson researches the risks for mother and baby during and after childbirth. Amongst other achievements, he has been able provide reassurance about the risks linked to bariatric surgery, antidepressants and COVID-19 infection in connection with pregnancy.

KI’s educational programmes should be world-leading both in their content and educational methodology. Terese Stenfors is studying how medical learning processes operate and works with the integration of research into KI’s own education.

Rickard Sandberg has developed a method of single-cell analysis that provides groundbreaking molecular insight into the properties and function of cells. The method is used around the world to examine normal and morbid tissue. He himself uses it to find out how DNA and cell identities are regulated.

Christina Samuelsson is hoping to make life easier for children and adults with communicative disabilities. Her research ranges from the importance of gestures for children with developmental language disorders to digital conversational support in elderly care homes.

A molecular dialogue between embryo and uterus is critical to pregnancy. Andres Salumets is researching this interaction to understand infertility and develop improved treatments for involuntary childlessness.

While exercise is good for us, we still do not fully understand why. Jorge Ruas is researching the nature of this connection at a molecular and genetic level in the hope of contributing to the development of better therapies.

Many elderly patients suffer from both physical conditions and cognitive impairments. Dorota Religa studies how the care of this patient group can be improved. Her research covers both pharmacological and organisational issues.

It is mainly poorly controlled type 2 diabetes that carries an elevated risk of cognitive impairment and dementia, not the diabetes per se, a longitudinal study by researchers at Karolinska Institutet in Sweden shows. The study comprises over 2,500 people and is published in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer's Association.

Bodil Lund is a dentist who is researching how the dental care services can help to stem antibiotic resistance by making more prudent use of antibiotics. Her work also includes the diagnosis and treatment of temporomandibular (TMJ or jaw joint) problems.

Maja Jagodic studies how the disease MS arises and why it affects people so differently. Research at an epigenetic level is appropriate both for understanding the disease and for finding new ways to treat it, she says.

Ultrasound has evolved into a very powerful medical imaging technique. Elisabeth Epstein researches how it can improve diagnostics for gynaecological diseases, including cancer.

Patients who receive trauma therapy often have multiple fractures and other orthopaedic injuries, which in themselves can prove fatal. Anders Enocson is researching how orthopaedic surgery for these patients can be improved – from choice of surgical method to cooperation within the trauma team.

Neuroscientist Ola Hermanson aims to both understand the development of the healthy brain and lay the groundwork for improved treatments for serious diseases. He is also keen to drive technological developments in bioprinting, amongst other areas.

Anna Koman at the research group Endocrine Surgery, the Department of Molecular Medicine and Surgery, will defend her thesis "Primary hyperparathyroidism: nonclassical symptoms and benefits of parathyroidectomy" on October 15th, 2021. Main Supervisor is Inga-Lena Nilsson.

The oral microbiome not only causes dental diseases, it also impacts on diseases elsewhere in the body. This is the focus of Margaret Sällberg Chen’s research, especially in relation to cancer.

Dr. Fang Fang, Professor at the Institute of Environmental Medicine (IMM) at Karolinska Institutet, has been awarded a grant of approximately 1.5 million US dollar for three years, from the Centers for Disease Control & Prevention (CDC), USA.

KI researchers Johan Lundin and Gunilla Karlsson-Hedestam receives research grant from the Erling-Persson Family Foundation, that supports projects in science, education, and development of children and young people.

In October, WHO and Karolinska Institutet arranged the first Rosling seminar on the theme "Health Equity and Pandemics – a Moonshot for Sustainable Health". It stressed that the path to sustainable health is through global cooperation and an international perspective where the focus is on the world's most vulnerable.

Three KI researchers have been awarded SSMF’s Large Grant, one of Sweden’s biggest grants for medical research. The researchers are allocated grants for four years of part- or full-time research with the goal of establishing an independent scientific career. This year the foundation received 153 applications, of which eight were granted.

The 2021 Nobel Prize in Chemistry rewards Benjamin List and David MacMillan for a new and ingenious tool for building molecules, asymmetric organocatalysis, which has contributed to more environmentally friendly chemical and pharmaceutical manufacturing. Here, KI researcher Per I Arvidsson, Head of the Drug Discovery and Development Platform at SciLifeLab, comments on the discovery. He was one of those who introduced organocatalysis in Sweden and believes that the prize was expected.

Davide Vetrano has received a 2 MSEK Junior Scholar Grant from the Strategic Research Area in Epidemiology and Biostatistics (SFOepi) for the project “Biomarker signatures of the multimorbidity-frailty continuum: in pursuit of personalized medicine for older adults.”

During the pandemic, it has become evident that people with cardiovascular disease and obesity are at much higher risk of developing very severe, even fatal COVID-19 disease. Researchers at Karolinska Institutet have identified some metabolic processes that SARS-CoV-2 uses to attack lung tissue. The results, which are published in Molecular & Cellular Proteomics, could one day be used to treat COVID-19, and potentially for other viruses like the Crimean-Congo hemorrhagic fever virus and HIV-1.

KI researchers receive 164 808 40 SEK in Forte's yearly call within the areas of responsibility: health, working life and welfare. In total, 32 projects, programmes and networks at KI recieve funding.

Dr Nicolas Pejovic has been awarded this year’s Rolf Zetterstöm prize for best thesis in pediatrics. The award was presented at Karolinska Institutet during Barnveckan. In his doctoral thesis No cry at birth. Neaonatal resuscitation in low resource setting: role of the laryngeal mask airway, Dr Pejovic investigates how midwives in low-resource settings could safely resuscitate newborns more effectively using a laryngeal mask instead of a conventional facemask.

A scientist at Karolinska Institutet reports that machine learning can be used to gain insights into molecular events that change the shape of proteins after they are made, regulating their ability to interact with each other. This suggests that artificial intelligence (AI) may allow us, in the future, to accurately simulate highly complex biological scenarios in silico as well as leverage this information for therapeutic intervention.

The 2021 Nobel Prize in Physiology or Medicine is about how people can feel temperature and touch. The discoveries explain basic functions in our lives and have opened doors to new treatments for pain, for example. We take it for granted, the fact that we can feel an icy wind, a hot plate or a hug, but how this actually works was unknown until it was discovered by the Nobel Laureates, a discovery made not so long ago.

Researchers at Karolinska Institutet have participated in a large international research project that has identified all cell types in the motor cortex, the part of the brain that controls movement. The research has resulted in a detailed cell atlas presented in a large special package of scientific articles in Nature today. The long-term goal of the collaboration is to create a cell atlas of the whole brain in order to increase knowledge of brain diseases and contribute to better treatments.

Scientists hope that tiny sacs of material excreted by cells – so-called extracellular vesicles – can be used to deliver drugs inside the body. Researchers at Karolinska Institutet now show that these nano-bubbles can transport protein drugs that reduce inflammation caused by different diseases. The technique, which is presented in Nature Biomedical Engineering, shows promising results in animal models.

At the end of September, a seminar tilted “How can we prepare ourselves for the next health crisis?” was held at KI with an expert panel including representatives of the Swedish Public Health Agency, the National Board of Health and Welfare and the Swedish Civil Contingencies Agency. Anders Nordström, the Swedish Ambassador for Global Health and Secretary of the WHO’s Independent Panel for Pandemic Preparedness and Response (IPPR), spoke on the WHO report “COVID-19: Make it the Last Pandemic”.

Christer Betsholtz, professor at the Department of Medicine Huddinge, Karolinska Institutet, has been awarded the major Nordic Prize for 2021 by the Eric K. Fernström Foundation. He receives one million SEK for his research into blood-vessel cells and their vascular structure and function.

BioNut researcher has received SEK 4.6 million in research grant from FORTE for a project on “Effects of increased ultra-processed food advertisement (outdoors and digital) exposure on behaviours associated with obesity development in Swedish adolescents, evaluated in a socioeconomic context.”

NVS congratulates them all!

Researchers at Karolinska Institutet have examined long-term outcomes in patients who received pacemaker implantations after transcatheter aortic valve replacement through their groin. The result showed no significant difference in mortality for the patients with pacemakers compared to those without. The study is published in the journal JACC: Cardiovascular Interventions.

It is well known that obesity affects the body's insulin production and over time risks leading to type 2 diabetes and several other metabolic diseases. Now researchers at Karolinska Institutet in Sweden have found further explanation for why fat cells cause metabolic morbidity. The study, published in Nature Medicine, may have an impact on the treatment of comorbidity in obesity with already available drugs.

The Swedish Society of Medicine honors Agneta Nordberg, professor in clinical neuroscience at Karolinska Institutet, with the Bengt Winblad Prize 2021.

Several substantial appropriations have been awarded to KI through the Swedish Research Council’s national research infrastructure initiative.
The Swedish Twin Registry (STR), Chemical Biology Consortium Sweden (CBCS) and the National E-infrastructure for Aging Research (NEAR) were all awarded funding through the Research Council.