News archive

Cardiogenic growth factors play important roles in heart development and in a new study published in the scientific paper Nature Communications from researchers at Karolinska Institutet shows how stem cell therapeutics and mRNA technology are beginning to converge offering major improvements in vascularization, survival, expansion, differentiation, and ultimately the function of human stem cell grafts.

Susanne Nylén at the Department of Microbiology, Tumor and Cell Biology at KI, is leading a project that has been awarded a four-year grant from the Dutch foundation Dioraphte for research on the pathogenesis of post-kala-azar dermal leishmaniasis (PKDL) and leprosy. The total amount awarded is 850 000 euros.

KI researcher Yihai Cao and his research group at the Department of Microbiology, Tumor and Cell Biology, have defined a new biomarker for predicting drug resistance of antiangiogenic therapy for the treatment of various cancers. The study is published in PNAS.

The 5D Heart Patch Project, led by Prof Kenneth Chien, has identified human ventricular progenitor (HVP) cells that can create self-assembling heart grafts in vivo. The research has the potential to offer hope to millions of people suffering from heart failure.

The first detailed description of the microbiota and immune cells among asymptomatic Helicobacter pylori-infected individuals has been published by researchers at Karolinska Institutet. The results of the study will be instrumental to understand the complex microbiome and immunity network and provide new insights for asymptomatic Helicobacter pylori infection.

PhD student Pradeepa Pushparaj, in Gunilla Karlsson Hedestam’s group at the Department of Microbiology, Tumor and Cell Biology, is the first author of a study recently published in Immunity. The study explains how antibody genes can influence the ability to make neutralizing antibodies to SARS-CoV-2.

Two KI researchers – Simon Elsässer and Magda Bienko – have been awarded 2022 European Research Council (ERC) Consolidator Grants totaling four million euro (nearly 45 million Swedish kronor). The funds will support two ambitious basic research projects that aim to further our understanding of the complex nature of our cells.

Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumours sensitive to a type of immunotherapy drug called a checkpoint inhibitor. This is according to a new study published in Cancer Immunology Research by researchers at Karolinska Institutet.

Congratulations to the many MTCers who have received grants or awards from Swedish funding agencies and from KI this November. No doubt, the department has a very strong future with all these wonderful projects!

The widely used gene scissor (CRISPR/Cas) can modify the genetic content in cells to study the molecular roles of genes and has gained great clinical relevance in gene therapy to treat genetic diseases. A new study performed by Claudia Kutter’s research group at the Department of Microbiology, Cell, and Tumor Biology at Karolinska Institutet, found that the gene scissor leads to unexpected genomic changes.

Sylvain Peuget, assistant professor at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet and his team has received 250,000 USD from the Swiss Bridge Foundation. The grant is aimed for continued research to investigate what role that certain bacteria in our intestinal flora play in the development and progression of colorectal cancer.

Professor Yihai Cao, Department of Microbiology, Tumor and Cell biology, is the corresponding author of a study recently published in PNAS, explaining how brown adipose tissue (BAT) can be increased in the adult human body.

In a recently published article in the journal Trends in Microbiology, author Alberto J. Martin-Rodriguez, Senior Research Specialist at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet, explains how he found that distinct bacterial strains selectively use respiration for surface colonization.

In a new publication in Nature communications, Martin Rottenberg and Ruining Liu, professor and PhD student at the Department of Microbiology, Tumor and Cellbiology, explains how T cell protection against Tuberculosis is controlled by their oxygen responses.

New research from Yihai Cao research group at the Department of Microbiology, Tumor and Cellbiology, MTC, shows that the so-called brown fat in the human body seems to be able to prevent cancer tumors from growing. The result is published by Nature and has been widely disseminated in the media lately.

In a study recently published in Cell Reports Methods, co- authors Björn Önfelt, Niklas Sandström and Valentina Carannante, researchers at SciLifeLab and the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet, describes a new miniaturized method for high-content screening combined with high-resolution imaging, all in the same microchip.

A study from Karolinska Institutet, among others, presents the theory that egg-sperm fusion, a crucial feature of sexual reproduction in plants and animals, may have originated from an ancient form of genetic exchange that involved the fusion of bacteria-like microorganisms called archaea. The results, published in Nature Communications, may open an entirely new perspective on the evolution of sex.

Using advanced microscopy techniques, researchers at Karolinska Institutet and Stockholm University have visualized in unprecedented detail the machinery that the cells’ powerhouses, the mitochondria, use to form their proteins. The results, which are published in Nature, raise hopes of more specific antibiotics and new cancer drugs in the future.

Researchers from Karolinska Institutet identify an epigenetic regulator controlling the very first cell type specification in the human embryo. The study is published in Nature Cell Biology.

Researchers at Karolinska Institutet, Germany’s Technical University of Munich (TUM) and AstraZeneca, among others, have identified a unique therapeutic approach with the potential to restore heart function following a heart attack. The new findings rely on so-called human ventricular progenitor (HVP) cells to promote novel heart tissue and reduce scarring after injury. This pre-clinical study is published in the journal Nature Cell Biology.

Primary cilia are signaling structures projecting off cell surfaces like antennae. In humans, many different cell types are ciliated. The molecular underpinnings of making and maintaining ciliary identities and functional specializations often are crucial for cell functionality. Recently, researchers have found how the main ciliogenic transcription factor protein controlling overall cilia biology can switch to control ciliary specializations and thereby alters cell behavioral output.

The Svedberg prize 2022 is awarded to Ben Murrell, Department of Microbiology, Tumor and Cell Biology, for his work characterizing antibody responses to viruses, especially the virus SARS-CoV-2.

A new study by researchers at Karolinska Institutet shows that the local activity of the signaling molecule Rac1 controls cycles of microscopic protrusions and retractions of the cell membrane. The cell uses these cycles to sense its surroundings, which among other things affects the cell's ability to move. Understanding of the cellular and molecular mechanisms that control cell movements, can help us to develop better diagnostics and treatment of various diseases such as cancer.

The Selivanova's group at MTC recently established a multidisciplinary collaboration together with Dr. Marie-Stéphanie Aschtgen, microbiologist in the Henriques-Normark groups (also at MTC) to study the interplay between bacteria and cancer, focusing on how specific bacterial systems influence host tumor supressors. Together they recently got their first collaborative paper accepted in Oncogene, entitled "Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization".

From our first breath, our lungs are exposed to microorganisms, such as bacteria and viruses. Thanks to immune cells in the lungs, so-called macrophages, we are protected from most infections at an early age. In a new study published in the Journal of Experimental Medicine, researchers from Karolinska Institutet show how lung macrophages develop; new findings that can help to reduce organ damage and that are significant for the continued development of important lung disease treatments.

The gold complex auranofin has traditionally been used for treating rheumatism but is also being evaluated as a treatment for certain forms of cancer. Researchers at Karolinska Institutet in Sweden now show that other molecules that inhibit the same biological system have a more specific effect than auranofin and therefore may have greater potential as cancer therapies. The results have been published in the journal Redox Biology.

Researchers at Karolinska Institutet have participated in a large international research project that has identified all cell types in the motor cortex, the part of the brain that controls movement. The research has resulted in a detailed cell atlas presented in a large special package of scientific articles in Nature today. The long-term goal of the collaboration is to create a cell atlas of the whole brain in order to increase knowledge of brain diseases and contribute to better treatments.

Scientists hope that tiny sacs of material excreted by cells – so-called extracellular vesicles – can be used to deliver drugs inside the body. Researchers at Karolinska Institutet now show that these nano-bubbles can transport protein drugs that reduce inflammation caused by different diseases. The technique, which is presented in Nature Biomedical Engineering, shows promising results in animal models.

It is well known that fat cells can influence our sensitivity to insulin. Now, researchers at Karolinska Institutet in Sweden have discovered that there are three different subtypes of mature fat cells in white adipose tissue and that it is only one of these, called AdipoPLIN, that responds to insulin. The findings may be relevant for future treatments of metabolic diseases such as Type 2 diabetes.

Researchers at Karolinska Institutet have analysed and described in detail the immune cells residing in the human bile duct. The findings may pave the way for new treatment strategies against disorders of the bile duct, which are often linked to immunological processes. The study is published in the journal Science Translational Medicine.

Hi there, Johanna Simin, PhD student in Clinical Epidemiology at the Centre for Translational Microbiome Research at Karolinska Institutet! You will defend your thesis entitled "The role of oestrogens and antibiotics on the development of cancer" on 1 June 2021. Can you tell us a little more?

The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous and vascular systems. The study, published in Nature Medicine, has potential implications for earlier diagnoses and future treatments.

Researchers at Karolinska Institutet show how a certain type of immune cells, macrophages, can be recruited into breast cancer tumors, where they are reprogrammed to support and drive tumor growth. In a study published in the scientific journal PNAS, they describe that low levels of the tumor suppressor protein TAp73 lead to hyperactivation of NFkB signaling and an inflammatory condition in breast cancer as well as secretion of molecules that recruit tumor-promoting macrophages into the tumor.

We can produce spider silk fibers stronger than those created by the spiders themselves. This according to the Professors Jan Johansson (KI) and Anna Rising (KI and SLU).

Researchers at Karolinska Institutet report in the journal Nature that they have developed novel first-in-class inhibitors that compromise mitochondrial function in cancer cells. Treatment with the inhibitors stopped cancer cells from proliferating and reduced tumour growth in mice, without significantly affecting healthy cells.

A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets. The findings are published in eLife and may be relevant for transplantation therapies in diabetes, as formation of functional blood vessels is important for the treatment to be successful.

While proteins on the surface of cells are the targets for most drugs, refined methods are needed to analyse how these membrane proteins are organised. Researchers at Karolinska Institutet have developed a new DNA-based analytical method that could contribute to the development of future drugs for breast and other cancers. The study is published in Nature Nanotechnology.

Georgios Sotiriou, Researcher at the Department of Microbiology, Tumor and Cell Biology receives the Smoluchowski award for his research contribution to the fields of aerosol science and technology. The award consists of a certification and a personal prize of 2.000 €.

KI researcher Federico Iovino has been awarded the Bjarne Ahlström's Minnesfonds pris 2020 (Bjarne Ahlström’s Memorial Fund Prize 2020) for his research in Clinical Neurology and on the study of inflammatory mechanisms that affect the function of the central or peripheral nervous system. The prize which consists of SEK 1000,000 is awarded annually and is distributed partly as an individual prize of SEK 50,000, partly as a research grant of SEK 950,000.

By conducting advanced analyses of immune system activation in patients with severe COVID-19, researchers at Karolinska Institutet have managed to identify several cell types that play a key part in the immune response to the new coronavirus and the hyperinflammation seen in severe cases of the disease. The results are published in the scientific journal Cell Reports Medicine.

Knowledge of how human fat tissue is affected by age has long been defined by numerous mouse-based studies. Researchers at Karolinska Institutet in Sweden have now, for the first time, been able to conduct a prospective study on humans that provides novel insights into how our fat cells reduce lipid metabolism with age. The study is published in the journal Cell Metabolism.

Researchers at Karolinska Institutet have discovered that excessive degradation of the power plants of our cells plays an important role in the onset of mitochondrial disease in children. These inherited metabolic disorders can have severe consequences such as brain dysfunction and neurological impairment. The study is published in EMBO Molecular Medicine.

The enzyme dihydroorotate dehydrogenase (DHODH), an essential component for the de novo pyrimidine ribonucleotide biosynthesis, has reemerged in the last few years as a target for the development of small molecules with anticancer and antiviral activity.

Researchers from Karolinska Institutet in collaboration with a lab in San Antonio USA, have uncovered how a specific population of lymphocytes promotes autoimmune disease by giving up their regulatory role in the immune system. The newly discovered mechanism is published in PNAS from research led by Dr. Saikiran Sedimbi and Prof. Mikael Karlsson.

When Human Immunodeficiency Virus Type 1 (HIV-1) infects a cell, the virus often becomes invisible to both the immune system and drugs. Now research from Karolinska Institutet shows that the integrated virus mimics a specific chromatin structure that lets the virus sequence remain accessible while preventing production of new viruses.

In a new study published in Nature Communications, researchers at Karolinska Institutet show that MAIT cells (mucosa-associated invariant T cells), part of the human immune system, respond with dynamic activity and reprogramming of gene expression during the initial phase of HIV infection. The study fills a knowledge gap, as previously there has been a lack of awareness of the function of MAIT cells during this particular phase.

Cognitive Behavioural Therapy (CBT) for patients with social anxiety not only helps to reduce anxiety levels but also seems to protect against accelerated cellular ageing, a study involving researchers at Karolinska Institutet published in the journal Translational Psychiatry reports.

The search for a cure to AIDS has partly focused on ways to eradicate infected cells. Now, new research from Karolinska Institutet in Sweden and the University of Pennsylvania in the U.S. shows that this approach may not be necessary for a functional cure. In a study focusing on a subset of HIV-positive individuals who can live with the virus without needing treatment, the researchers found that these people’s lymphocytes suppress the virus but do not kill off infected cells.

Researchers at Karolinska Institutet have developed a new method for identifying which proteins are affected by specific drugs. The tool and the results it has already generated have been made freely available online. The method is described in the scientific journal Nature Communications.

Researchers have long known that some genes can cause cancer when overactive, but exactly what happens inside the cell nucleus when the cancer grows has so far remained enigmatic. Now, researchers at Karolinska Institutet in Sweden have found a new mechanism that renders one canonical driver of cancer overactive. The findings, published in Nature Genetics, create conditions for brand new strategies to fight cancer.