News archive

Anti-rheumatic drugs used for rheumatoid arthritis might prevent the development of autoimmune thyroid disease, according to a new observational study by researchers from Karolinska Institutet published in the Journal of Internal Medicine.

In a new study from Karolinska Institutet, the researchers found that combining information from blood markers and genetics reveals distinct subgroups of patients with myositis, which may help to improve disease classification and treatment. The study was published in EBioMedicine.

Women with rheumatic diseases are at greater risk of complications during pregnancy and childbirth, but for women with axial spondyloarthritis the risks have decreased over the last ten years, according to a register study from Karolinska Institutet. This decrease coincided with an increased use of biologic drugs during the same period. The study was published in The Lancet Rheumatology.

Many patients with the autoimmune disease ANCA-associated vasculitis (AAV) suffer a high risk of disease relapse despite treatment. KI researchers have now identified T cells that contribute to the destruction of kidney tissue in patients with AAV and suggest the possibility of T cell screening to identify individuals at high risk. The study was published in Kidney International.

Researchers from Karolinska Institutet have compared high dose exercise therapy versus low dose in patients with symptomatic knee osteoarthritis. The study published in the journal Annals of Internal Medicine show that both groups had similar results. However, high dose exercise therapy provided superior outcomes related to function in sports and recreation in the short term, with results subsiding after six months.

Breathing in common workplace dust and fumes may increase the risk of developing severe rheumatoid arthritis, especially in combination with smoking and genetic susceptibility to the disease, suggests a new study from Karolinska Institutet published in The Annals of the Rheumatic Diseases.

With new digital tools in healthcare, researchers at Karolinska Institutet, with collaborators, are hoping to prevent cases of rheumatoid arthritis. They recently collected a total of 3.5 million euro (around 38 million Swedish kronor) for the so-called DigiPrevent project, most of which comes from EIT Health, a network established by the European Institute of Innovation and Technology.

Christina Opava, professor emerita at the Division of Physiotherapy is awarded the EULAR Health Professionals in Rheumatology Lifetime Achievement Award 2022 for her work within rheumatology.

EIT Health Scandinavia International has awarded SEK 23 million in research grants to support international collaboration in precision prevention in rheumatology, with almost half of the grant distributed to Karolinska Institutet and Region Stockholm. The scope of the project includes creating the conditions for the early diagnosis of risk factors for developing RA (rheumatoid arthritis) and enabling patients at risk of developing RA to manage the risk through lifestyle changes.

Alex Moreno, Ana Coelho and Alexander Krämer were awarded a prize for best podcast episode by the European consortium “Combatting Disorders of Adaptive Immunity with Systems Medicine”, COSMIC. Out of the five recorded podcast episodes, the PhD students' episode with the title “The ethics behind the use of animal models in biomedical research” won the consortium’s prize.

Two clinical researchers at KI have been appointed Wallenberg Clinical Scholars 2020. The individual funding of SEK 15 million from Knut and Alice Wallenberg Foundation provides Anca Catrina and Mikael Rydén with the opportunity to deepen their research and disseminate their results in healthcare.

Endogenous proteins that play a vital part in allergies and parasitic infection can prevent the immune system from wrongly attacking the body and causing inflamed joints, a study from Karolinska Institutet published in the scientific journal PNAS reports. The researchers hope that the results will give rise to new drugs for rheumatoid arthritis.

Christina H. Opava summarized her career at KI in an entertaining talk prior to her retirement, led by Yvonne Enman, journalist and honorary doctor at KI.

Myriam Aouadi and Camilla Svensson have been awarded the European Research Council’s Consolidator grant 2019 for research on the role of macrophages in liver disease and how autoantibodies contribute to chronic pain, respectively.

Four research projects at Karolinska Institutet receive funding from the Knut and Alice Wallenberg Foundation (KAW) in the project call of 2019. In all, researchers at KI are awarded close to SEK 135 million over a five-year period for studies into MS, mitochondrial disease, and vaccine against rheumatism.

Antibodies present in the blood years before development of painful chronic joint inflammation may cause early changes in the synovial tissue and bones, according to a study by researchers at Karolinska Institutet published in the journal Annals of the Rheumatic Diseases. The findings could pave the way for new methods of preventing development of the disease.

Antibodies that exist in the joints before the onset of rheumatoid arthritis can cause pain even in the absence of arthritis, researchers from Karolinska Institutet in Sweden report. The researchers believe that the finding, which is published in the Journal of Experimental Medicine, can represent a general mechanism in autoimmunity and that the results can facilitate the development of new ways of reducing non-inflammatory pain caused by rheumatoid arthritis and other autoimmune diseases.

This spring the first version of the mHealth service tRAppen will be released. It is hoped that it will provide patients with better opportunity to take responsibility for and affect their health positively. The development of tRAppen is described in a thesis who Åsa Revenäs, physiotherapist and PhD at the Division of Physiotherapy, defended on the 5th of February 2016.