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Children of a parent with alcohol or drug use disorder have a greater risk of intellectual disability, even if the problem only lies with the father, researchers from Karolinska Institutet report. According to the study, which is published in the journal eClinicalMedicine, preventive measures should be directed at both parents.

Children of parents with mental illness are at increased risk of being born too early, especially if it is stress-related, and both the mother’s and the father’s mental health seem to be of importance. This is according to a register-based study from Karolinska Institutet published in PLOS Medicine.

Bipolar disorder underlies roughly five percent of all suicides among young people. Previous studies also show that there is often a long delay between the onset of bipolarism and its correct diagnosis and treatment. Researchers at Karolinska Institutet now show that fewer boys commit suicide in Swedish regions where bipolar diagnoses are more common. The study, which is published in JAMA Psychiatry, could contribute to more proactive care for reducing the number of suicides.

The award is presented by the Pediatric research foundation ”Stiftelsen Barnforskningen” at the Astrid Lindgren Children’s hospital.

Juliet Mwanga-Amumpaire is a paediatrician and Associate Professor of paediatrics at Mbarara University with over ten years of experience conducting clinical research. She is currently the director of Epicentre Mbarara Research Centre run by Médecins Sans Frontières that conducts health related research aiming to guide policy for stakeholders in health. She recently pursued her PhD where she studied the quality of care at private health facilities in Uganda.

Researchers from Karolinska Institutet and Sachs’ Children and Youth Hospital have mapped the immune system in the gut of children with inflammatory bowel disease (IBD). The results, which were published in Cell Reports Medicine, can be used to design more targeted therapies.

UNICEF Sweden, UNICEF Office of Innovation and the Swedish Network for Global Child Health hosted a seminar to discuss The State of the World’s Children (SOWC), a bi-annual report published by UNICEF. This year it focuses on routine childhood vaccinations. Tobias Alfvén and Stefan Swartling Peterson from Karolinska Institutet moderated the panel discussions From Vaccine to Vaccination and Convergence of State of the World's Children and EU global health strategy.

The newborn care researchers in the team Global Child Health and Sustainable Development Goals, have visited research colleagues at the Phu San Hospital in Hanoi, Vietnam. The visit included meetings with the director and vice-director of Phu San, Dr Nguyen Duy Anh and Dr Nguyen Thi Thu Ha, visits to hospital departments, presentation of ongoing and upcoming research, workshops, simulation trainings and planning of studies including the NeoSpirit project and future Vietnamese PhD candidates.

Medical sleep treatment may reduce self-harm in young people with anxiety and depression, an observational study from Karolinska Institutet suggests. The risk of self-harm increased in the months preceding melatonin prescription and decreased thereafter, especially in girls. The study is published in The Journal of Child Psychology and Psychiatry.

Infants whose mothers have used snus (a moist oral tobacco product) during pregnancy run three times the risk of sudden infant death, according to a comprehensive registry study from Karolinska Institutet published in the journal Pediatric Research. The risk was much lower if the mother had stopped taking snus before the first antenatal visit. The researchers conclude that all types of nicotine products should be avoided during pregnancy.

This year's first edition of Barnläkaren, the Swedish Paediatric Assosiaction's magazine, is published. The theme of the latest issue is global health and the Global Child Health and Sustainable Development Goals research team leader Tobias Alfvén was the guest editor. Download the paper to read about the research from the child health team members.

Nataliia Petryk ran a private clinic in Kyiv helping women give birth when she was forced to flee Ukraine when Russia invaded her country. By following a call by the European Research Council for EU teams to take in Ukrainian scientists, she is now able to conduct research to prevent miscarriage at Karolinska Institutet. Her experience is an example of how science knows no borders.

The newborn care researchers in the global child health and sustainable development goals team have had a visit from research colleagues at the Phu San Hospital in Hanoi, Vietnam, November 23-26. The visit included workshops on ongoing and upcoming collaborations and studies including the NeoSpirit project and planning for future Vietnamese PhD candidates as well as visiting hospitals.

An observational study at Karolinska Institutet shows that babies suffering oxygen-deficiency complications at birth are almost twice as likely to develop cardiovascular disease during childhood and early adulthood as those without such complications. Still, the absolute risk of cardiovascular disease is very low in young age. The findings are published in the journal The Lancet Regional Health – Europe.

Screening programmes for childhood hearing loss need to become better at collecting data and measuring outcomes in order to increase quality, such as improving the percentage of follow-ups, a new thesis from Karolinska Institutet reports.

During the Annual pediatric IBD meeting in Örebro on September 29-30, Jonas F Ludvigsson received this year’s honorary award "the Gut Feeling" SPGHN, the Swedish Association for Pediatric Gastroenterology, Hepatology and Nutrition, amidst the cheers of the audience. The prize is awarded after voting by pediatricians in Sweden.

The research team Global Child Health and the Sustainable Development Goals in collaboration with the Nobel Prize Museum hosted a seminar on global child health as part of the Nobal Calling Stockholm week. Juliet Mwanga-Amumpaire from Mbarara University in Uganda and Tobias Alfvén, associate professor at the Department of Global Public Health, discussed why five million children die every year and what is needed for more children to survive.

Children with certain immunodeficiency diseases carry mutations in genes that regulate the body’s immune system against viral infections and they have a higher mortality rate due to COVID-19. This is according to a study by researchers from Karolinska Institutet, published in the Journal of Allergy and Clinical Immunology.

Conflict causes deaths and injuries, as well as health consequences from the displacement of populations, breakdown of health services and an increased risk of disease transmission. But in DRC that has suffered from conflict and instability for decades, conflict alone is a poor indicator for child health. In his study, Mattias Schedwin, compares coverage of key child health policy indicators across provinces in DRC and their association with child mortality and level of conflict in the country.

To track and analyze caesarean section trends and thus improve maternity care, the Robson classification is used worldwide. A study from Karolinska Institutet in Sweden shows differences between Sweden and Canada, and that the classification system can be further developed to take into account more important variables. The study, published in PLOS Medicine, may contribute to improved and more equal maternity care in the future.

Infants who were given a taste of peanut, milk, wheat and egg from the age of three months had a lower risk of developing a food allergy at the age of three years than controls, reports a study by researchers from Karolinska Institutet in Sweden and the University of Oslo in Norway published in The Lancet.

Severe acute COVID-19 is very rare in children, but SARS-CoV-2 infection can trigger a novel post infectious condition called Multisystem Inflammatory Syndrome in Children (MIS-C). MIS-C is a potentially serious condition, and so far, little has been known on risk factors for developing MIS-C.

In March 2022, André Thunberg had his ISP seminar at the Department of Global Public Health. His research focuses on the prevalence and management of severe paediatric illness in Malawi. Besides his doctoral studies, André also works at Astrid Lindgren Children’s Hospital as a resident doctor.

A mobile app that shows a child's weight development in real-time for children with obesity provides greater weight loss compared to conventional care. The fact that both families and healthcare professionals can follow the same data facilitates individualised extra support when needed. This is shown by a study from Karolinska Institutet published in the International Journal of Obesity.

Screen time is often associated with poor health in young people, but it is more complicated than that, say researchers. We are affected, but differently and not just negatively. What we do on our phones – and what we do when we are not using them – also plays a role in our well-being.

A study in rural Malawi underscores the need for better clinical management of severely ill children with very low blood sugar or blood oxygen levels. The study by researchers at Karolinska Institutet in Sweden and the Parent and Child Health Initiative in Malawi, among others, found high mortality rates for children with either of these symptoms even when they were admitted to a hospital. The findings are published in the journal Bulletin of the World Health Organisation.

Millions of Ukrainian children have been displaced, either internally or as refugees, by the war with Russia. A systematic review by researchers at Karolinska Institutet and Ukraine’s Sumy State University has compiled the scientific literature on children’s health in Ukraine. The study, which is published in the journal Acta Paediatrica, could prove useful for clinicians treating refugee children from Ukraine.

Children with migration backgrounds in Sweden are less likely than other children to receive recommended treatment for psychiatric diagnoses such as ADHD and depression, a paper from Karolinska Institutet published in the journal Epidemiology and Psychiatric Sciences reports.

The risk of adverse pregnancy outcomes in women who tested positive for SARS-CoV-2 is likely lower than several earlier studies have suggested, a national study of all pregnant Swedish women tested for SARS-CoV-2 between March 2020 and January 2021 reports. The study, published in BJOG: An International Journal of Obstetrics and Gynaecology and led by researchers at Karolinska Institutet, shows that the association varies widely depending on the routines used for testing pregnant women.

Research on the role of diet in the development of type 1 diabetes is generally of low evidence, but there are some high-quality studies indicating that longer breastfeeding and later introduction to gluten may reduce the risk of disease. That is according to a systematic review and meta-analysis of available research on foods that may be linked to the risk of developing the type 1 diabetes in childhood. The study by researchers at Karolinska Institutet is published in the journal EBioMedicine.

Neuroblastoma is a type of childhood cancer that develops in infants and young children. Whilst it is a relatively rare form of cancer, it is still responsible for approximately 15 percent of all cancer deaths in children. In a new study published today in Nature Communications, researchers at Karolinska Institutet have discovered that low-risk and high-risk neuroblastoma have different cell identities, which can affect the survival rate.

Children and young people whose mothers had a BMI greater than 30 during early pregnancy are at an increased risk of fatty liver disease. This is shown in a register-based study from Karolinska Institutet and Harvard University published in the journal Journal of Hepatology. As obesity rates increase also in women at a child-bearing age, more and more young people are at risk of developing fatty liver disease, the researchers say.

With the development of more effective treatment for childhood cancer, fertility preservation efforts have become routine at many centers. At the same time, there have been questions about the risks of relapse when re-transplanting ovarian tissue. Now researchers at Karolinska Institutet report on a woman who is expecting her second child after being treated for leukaemia as a teenager. This study, published in Haematologica, may be of great importance to many young women and their families.

Thanks to many years of translational research, some children with the rare childhood cancer neuroblastoma may now be cured. In a study published in the Journal of Clinical Oncology, researchers at among others Karolinska Institutet and University of Gothenburg write that so-called ALK inhibitors should be tried to treat children with high-risk neuroblastoma. That is after an analysis showed that children with mutations in the ALK gene have poorer prognosis.

Early intervention for disruptive behaviour disorders in children reduces the risk of antisocial development and psychiatric problems later in life. Parental training and child CBT are two interventions about which more needs to be known concerning the effects on disruptive behaviour disorders. According to a new doctoral thesis from Karolinska Institutet, both have a positive effect on such disorders, where severity should determine the choice of treatment.

Many diseases caused by a dysregulated immune system, such as allergies, asthma and autoimmunity, can be traced back to events in the first few months after birth. To date, the mechanisms behind the development of the immune system have not been fully understood. Now, researchers at Karolinska Institutet show a connection between breast milk, beneficial gut bacteria and the development of the immune system. The study is published in Cell.

Researchers at Karolinska Institutet found industrial chemicals in the organs of fetuses conceived decades after many countries had banned the substances. In a study published in the journal Chemosphere, the researchers urge decision makers to consider the combined impact of the mix of chemicals that accumulate in people and nature.

Continuous skin-to-skin contact starting immediately after delivery even before the baby has been stabilised can reduce mortality by 25 per cent in infants with a very low birth weight. This according to a study in low- and middle-income countries coordinated by the WHO on the initiative of researchers at Karolinska Institutet published in The New England Journal of Medicine.

Researchers at Karolinska Institutet and the Public Health Agency of Sweden have studied newborn babies whose mothers tested positive for SARS-CoV-2 during pregnancy or childbirth. The results show that although babies born of test-positive mothers are more likely to be born early, extremely few were infected with COVID-19. The study, which is published in the esteemed journal JAMA, supports the Swedish recommendation not to separate mother and baby after delivery.

A study involving researchers at Karolinska Institutet and IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – demonstrates how zika and herpes viruses can lead to brain malformations during early pregnancy. The researchers used 3D models of human brains to study which mechanisms are involved in virus-induced microcephaly, a condition where babies are born with smaller-than-usual heads. The results are published in the journal Cell Stem Cell.

Many researchers agree that shifting to a more plant-based diet is an important step towards reducing our impact on the climate. A new doctoral thesis from Karolinska Institutet describes the development and test of a new method of providing sustainable school lunches. The new lunch resulted in a 40 per cent reduction in climate impact with no increase in cost or decrease in consumption.

How the immune system adapts to pregnancies has puzzled scientists for decades. Now, findings from an international group of researchers, led by researchers at Karolinska Institutet in Sweden, reveal important changes that occur in the thymus to prevent miscarriages and gestational diabetes. The results are published in the journal Nature.

Depressed children and teenagers have an increased risk of suffering from premature death and a wide range of illnesses later in life. That is according to a large observational study by researchers at Karolinska Institutet in Sweden. The findings highlight the need to look for other potential diseases following childhood or adolescent depression. Other psychiatric conditions, such as anxiety and substance misuse, can explain part of the association. The study is published in JAMA Psychiatry.

Birth asphyxia is one of the most common causes of neonatal death. Researchers at Karolinska Institutet and others have now evaluated a method of resuscitation not previously used by midwives. The study, which is published in The New England Journal of Medicine shows that a laryngeal mask is a safe and easy-to-use alternative to other methods and one that is particularly suitable for use in low-income countries.

Women with breast cancer whose eggs or ovarian tissue were frozen had more children after their diagnosis than women who did not undergo fertility preservation using those methods before start of cancer treatment. That is according to a study by researchers at Karolinska Institutet in Sweden, published in JAMA Oncology. According to the researchers, the result highlights the importance of reproductive counseling and fertility preservation for women who are diagnosed with cancer at a young age.

Recent data suggest that adults may experience long-term symptoms after COVID-19 infection, but if such symptoms also occur in children is still unknown. Children tend to have milder COVID-19 than adults, but in a case-report from Sweden, Professor and pediatrician Jonas F Ludvigsson describes five children with potential “long COVID”. These findings, together with a systematic review of long COVID in children, are published in the journal Acta Paediatrica.

A new study has found that a commonly prescribed anti-depressant may halt growth of a type of cancer known as childhood sarcoma, at least in mice and laboratory cell experiments. The findings, from researchers at Karolinska Institutet in Sweden and MD Anderson Cancer Centre in Texas, ignite hope of novel treatment strategies against this disease. The study is published in the journal Cancer Research.

Researchers at Karolinska Institutet and Science for Life Laboratory in Sweden and Tor Vergata University of Rome in Italy have mapped the immune response in children affected by a rare but life-threatening inflammatory syndrome associated with COVID-19. The study, which is published in the scientific journal Cell, reveals that the inflammatory response differs from that in Kawasaki disease and severe acute COVID-19.

Two recent studies were unable to rule out that H1N1 (“swine flu”) vaccination (“Pandemrix”) and seasonal influenza vaccination given to pregnant women might be associated with autism spectrum disorder in the offspring. Now, a large study by researchers at Karolinska Institutet in Sweden, published in the journal Annals of Internal Medicine, refutes any such association.

Professor Jonas F Ludvigsson, at MEB, KI has been appointed national scientific expert in pediatrics at the Swedish National Board of Health and Welfare.