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People with at least two of the diseases type 2 diabetes, heart disease or stroke have double the risk of developing dementia. Prevention of diabetes and cardiovascular disease could therefore be a strategy for reducing dementia risk, a study from Karolinska Institutet published in the journal Alzheimer’s & Dementia suggests.
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Researchers at Karolinska Institutet in Sweden show how a molecule that they have identified stimulates the formation of new insulin-producing cells in zebrafish and mammalian tissue, through a newly described mechanism for regulating protein synthesis. The results are published in Nature Chemical Biology.
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Mechanisms associated with a particular diabetes drug can also help to protect against Alzheimer’s disease, a study by researchers at Karolinska Institutet and published in Neurology reports. The results indicate that the drug’s target protein can be an interesting candidate for the treatment of Alzheimer’s disease.
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A team of scientists including at Karolinska Institutet has used mini-kidneys simulating those of diabetic patients to further our understanding of the link between diabetes and COVID-19. The researchers found that diabetic mini-kidneys have a higher susceptibility to SARS-CoV-2 infection than non-diabetic mini-kidneys. The study, which is published in the journal Cell Metabolism, also identified genetic evidence for the essential role of the ACE2 receptor in COVID-19.
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High blood glucose is responsible for several complications in type 1 and type 2 diabetes. Researchers at Karolinska Institutet have identified a new antidiabetic substance that preserves the activity of insulin-producing beta cells and prevents high blood glucose in mice. The study is published in the journal Science Translational Medicine.
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A new study from Karolinska Institutet sheds new light on how diabetes causes tissue damage when oxygen levels drop, and point to the repression of a protein complex as a possible treatment target for diabetes complications. The findings are published in the journal eLife.
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KI researcher Myriam Aouadi is awarded the Leif C. Groop award for her research about the mechanisms behind the development of non-alcoholic fatty liver disease in obese individuals with type 2 diabetes.
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People with type 2 diabetes have an increased risk of stroke and slower recovery from it. Now, researchers at Karolinska Institutet have shown that neurological recovery from stroke is significantly improved in mice with obesity and diabetes who achieve weight loss to the extent that glucose metabolism returns to normal levels. The results are published in the scientific journal Cardiovascular Diabetology and may have clinical relevance for stroke rehabilitation in type 2 diabetes.
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The Strategic Research Programme in Diabetes at Karolinska Institutet started a new initiative earlier this year – the SRP Diabetes Postdoctoral Fellowship Programme. With this postdoctoral program SRP Diabetes aims to support the next generation of exceptional young scientists within the diabetes area, including both experimental and clinical research.
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Audience: Medarbetare
Molekylär medicin och kirurgi, Integrativ fysiologi, Fysiologi och farmakologi, Integrativ Fysiologi, Klinisk forskning och utbildning, Södersjukhuset, Medicin, Huddinge, Mikrobiologi, tumör- och cellbiologi, FyFa, Klinisk vetenskap, intervention och teknik
Altered function of the red blood cells leads to vascular damage in type 2 diabetes. Results from a new study in cells from patients with type 2 diabetes and mice show that this effect is caused by low levels of an important molecule in the red blood cells. The study by researchers at Karolinska Institutet in Sweden has been published in the journal Diabetes.
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Muscle cells in patients with type 2 diabetes have a disrupted biological clock discover researchers at the University of Copenhagen and Karolinska Institutet. The findings, published in the journal Science Advances, suggest that treatments for type 2 diabetes may be more or less effective depending on the time of day they are given.
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Research on the role of diet in the development of type 1 diabetes is generally of low evidence, but there are some high-quality studies indicating that longer breastfeeding and later introduction to gluten may reduce the risk of disease. That is according to a systematic review and meta-analysis of available research on foods that may be linked to the risk of developing the type 1 diabetes in childhood. The study by researchers at Karolinska Institutet is published in the journal EBioMedicine.
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It is mainly poorly controlled type 2 diabetes that carries an elevated risk of cognitive impairment and dementia, not the diabetes per se, a longitudinal study by researchers at Karolinska Institutet in Sweden shows. The study comprises over 2,500 people and is published in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer's Association.
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It is well known that obesity affects the body's insulin production and over time risks leading to type 2 diabetes and several other metabolic diseases. Now researchers at Karolinska Institutet in Sweden have found further explanation for why fat cells cause metabolic morbidity. The study, published in Nature Medicine, may have an impact on the treatment of comorbidity in obesity with already available drugs.
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Professor Juleen R. Zierath receives the 2021 prestigious EASD Claude Bernard Award. This award recognizes an individual’s innovative leadership and lifetime achievements in diabetes research and is the EASD’s highest award.
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Assistant Professor Rongrong Fan at the Department of Biosciences and Nutrition is among the 4 grantees in Europe who have received 5 million DKK for 5 years from the EFSD / Novo Nordisk Future Leaders Award program in 2021. This highly competitive grant supports young and promising researchers of excellence who wish to further develop their career in Europe to investigate the mechanisms of diabetes.
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Assistant Professors Nicolas Pillon at Department of Physiology and Pharmacology and Rongrong Fan at Department of Biosciences and Nutrition have both been awarded the 2021 Future Leaders Award by EFSD (European Foundation for the Study of Diabetes)/Novo Nordisk Foundation. This is a competitive 5-year grant to support PIs to become future leaders in diabetes research.
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It is well known that fat cells can influence our sensitivity to insulin. Now, researchers at Karolinska Institutet in Sweden have discovered that there are three different subtypes of mature fat cells in white adipose tissue and that it is only one of these, called AdipoPLIN, that responds to insulin. The findings may be relevant for future treatments of metabolic diseases such as Type 2 diabetes.
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Jiaojiao Zheng from the research group Upper GI Surgery, the Department of Molecular Medicine and Surgery, will defend her thesis "Diabetes, metformin and gastric adenocarcinoma" on June 11, 2021. Main Supervisor is Professor Jesper Lagergren.
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With this postdoctoral programme SRP Diabetes aims to support the next generation of exceptional young scientists within the diabetes area, including both experimental and clinical research. To promote cross-fertilization between research environments, we encourage scientists wishing to pursue postdoctoral training in a different university from where they carried out doctoral studies. Openings for fellowships in 5 different laboratories at Karolinska Institutet.
Deadline June 6!
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Non-alcoholic fatty liver disease, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients with the goal of reducing the risk of cancer.
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Hi there Ying Shang, PhD student at the Aging Research Center (ARC). You will be defending your thesis entitled “How can older adults combat diabetes to achieve a longer and healthier life?” on 16 April 2021. Could you tell us a little more about it?
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SRP Diabetes organize a new webinar series - "Diabetes Fridays" with internationally recognized speakers in the area of diabetes and metabolism, often in combination with a talk by a researcher from KI or UmU on a similar topic as the external guest.
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Intake of a high-fat diet leads to an increased risk for obesity, type 2 diabetes, cardiovascular diseases and fatty liver. A study in mice from Karolinska Institutet shows that it is possible to eliminate the deleterious effects of a high-fat diet by lowering the levels of apolipoprotein CIII (apoCIII), a key regulator of lipid metabolism. The study is published in the journal Science Advances.
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SRP Diabetes PI Juleen R. Zierath receives the 2021 Harold Rifkin Award for Distinguished International Service in the Cause of Diabetes from American Diabetes Association (ADA).
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Hi Juraj Sečník, PhD student at the Division of Clinical Geriatrics! On January 29 you will defend your thesis “Diabetes mellitus in patients with dementia : clinical care and pharmacological treatment”. What’s the main focus of the thesis?
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A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets. The findings are published in eLife and may be relevant for transplantation therapies in diabetes, as formation of functional blood vessels is important for the treatment to be successful.
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Researchers at Karolinska Institutet and Danderyd Hospital have studied the risk of additional myocardial infarctions and early death in severely obese patients who undergo metabolic surgery following a myocardial event. The registry study covering 1,018 individuals shows a lower risk of additional myocardial infarctions and improved survival that cannot be simply attributed to the loss of weight. The study is published in the journal Circulation.
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Nils-Göran Larsson receives a project grant in Endocrinology & Metabolism of DKK 2 million from the Novo Nordisk Foundation. We’ve talked to him about the project that investigates the role of mitochondria in the development of obesity-associated insulin resistance.
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According to many observations, certain virus infections may play a part in the autoimmune attack that leads to type 1 diabetes. Researchers at Karolinska Institutet in Sweden and their Finnish colleagues have now produced a vaccine for these viruses in the hope that it could provide protection against the disease. The study is published today in the scientific journal Science Advances.
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Use of sodium glucose cotransporter 2 (SGLT2) inhibitors to treat type 2 diabetes may help to lower the risk of serious kidney problems, according to a Scandinavian study led by researchers at Karolinska Institutet. The findings, now published in the journal The BMJ, provide support for the use of SGLT2 inhibitors in a broad range of patients with type 2 diabetes, according to the researchers.
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Two clinical researchers at KI have been appointed Wallenberg Clinical Scholars 2020. The individual funding of SEK 15 million from Knut and Alice Wallenberg Foundation provides Anca Catrina and Mikael Rydén with the opportunity to deepen their research and disseminate their results in healthcare.
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Dr Franz Matschinsky, Professor of Biochemistry and Biophysics, Institute for Diabetes, Obesity and Metabolism Perelman School of Medicine, Philadelphia receives the 2020 Rolf Luft Award for the discovery that glucokinase (GK) is the sensor controlling glucose-stimulated insulin secretion in the pancreatic beta cell.
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Researchers at Karolinska Institutet have deciphered the diabetogenic role of a certain type of calcium channel in insulin-secreting beta cells. The researchers believe that blockade of these channels could be a potential new treatment strategy for diabetes. The study is published in the scientific journal PNAS.
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Patients with ALS (amyotrophic lateral sclerosis) often suffer from type 2 diabetes. This phenomenon has since long remained mechanistically enigmatic. Now, researchers at Karolinska Institutet in Sweden have identified a molecular mechanism linking these two diseases. The study is published in the scientific journal PNAS.
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Hello there, Sergiu Catrina - Associate Professor, Specialist Physician and Research Leader for the Growth and Metabolism Group at the Department of Molecular Medicine and Surgery.
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Children born to women who underwent gastric bypass surgery before becoming pregnant had a lower risk of major birth defects than children born to women who had severe obesity at the start of their pregnancy. That’s according to a matched cohort study by researchers at Karolinska Institutet and Örebro University published in the scientific journal JAMA. The findings indicate that weight-loss and improved blood sugar control could reduce the risk of major birth defects.
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Drivers, factory workers, and cleaners are three times more likely to develop type 2 diabetes than teachers and physiotherapists. Researchers at Karolinska Institutet in Sweden have studied how the occurrence of diabetes differs between occupations in Sweden. The results are being published in the scientific journal Diabetologia and are also presented at the European diabetes conference in Barcelona in September.
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The new type of drugs for type 2 diabetes, the so-called SGLT2 inhibitors, are associated with a reduced risk of heart failure and death as well as of major cardiovascular events, a major Scandinavian registry study led from Karolinska Institutet reports in The BMJ.
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The paper's motto was: ”Among women with diabetes and high HbA1c, there is a risk that the fetus too early the outside world will see”

The winning study was led by Professor Jonas F Ludvigsson, Department of Medical Epidemiology and Biostatistics, KI, and shows that pregnant women with type 1 diabetes are at increased risk of pregnancy complications, including preterm birth. With increasing HbA1c the risk of preterm birth increased further.
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The hormone secreting part of the pancreas, the islets of Langerhans, has a unique cyto-architecture that allows functional interrelationships between the different cell types. Somatostatin is secreted by the delta cell and is an effective inhibitor of the insulin secreting beta cell and the glucagon secreting alpha cell. According to a novel study from Karolinska Instiutet, published in the journal Nature Communications, the delta cell can thereby indirectly affect glucose homeostasis
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People with undetected glucose disorders run a higher risk of both myocardial infarction and periodontitis, according to a study published in the journal Diabetes Care by researchers at Karolinska Institutet. The results demonstrate the need of greater collaboration between dentistry and healthcare, say the researchers, and possibly of screening for diabetes at dental clinics.
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By the time type 1 diabetes is diagnosed, most of the insulin-producing beta cells have already been destroyed. Now, using an innovative transplantation technique, researchers at Karolinska Institutet and University of Miami Miller School of Medicine have been able to intervene to save the beta cells in mice by discovering early signs of the disease. The study is published in Diabetologia, the scientific journal of the European Association for the Study of Diabetes (EASD).
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Pregnant women with type 1 diabetes are at increased risk of delivering their baby prematurely. The risk increases as blood sugar levels rise, however women who maintain the recommended levels also risk giving birth prematurely. These are the findings from researchers at Karolinska Institutet and the Sahlgrenska Academy in Sweden, published in Annals of Internal Medicine.
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The ERC Advanced Grant is one of the most prestigious funding programmes for research in Europe. Per-Olof Berggren, professor of experimental endocrinology at Karolinska Institutet, is now awarded this grant for the second time.
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Olov Andersson, docent at the Department of Cell and Molecular Biology at Karolinska Institutet, is the recipient of The Leif C. Groop award for outstanding research for his research in zebrafish that could lead to new treatments for diabetes. Awarded by the Lund University Diabetes Centre and sponsored by Novo Nordisk Sweden.
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Professor Mitchell Lazar at Perelman School of Medicine, University of Pennsylvania, Philadelphia has been selected as recipient of the Rolf Luft Award 2019.
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Knowledge of a newly discovered genetic disorder, which means that a person cannot produce the protein TXNIP (thioredoxin interacting protein) in their cells, can open for the development of new diabetes drugs. This is shown in a study from Karolinska Institutet published in the journal Diabetes.
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08-06-2022