News archive

The Board of Sven and Ebba-Christina Hagberg's foundation has decided to award Bahira Shahim and David Marlevi the foundations personal prize and a research grant, for a total of SEK 650,000 each. The prize will be awarded at the annual Installation Ceremony at the Karolinska Institutet in October 2025.

After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart. This is according to a new study from Karolinska Institutet published in the journal Circulation.

Hi Marko Bogdanovic, doctoral student at the Vascular Surgery research group, Department of Molecular Medicine and Surgery.

You will defend your thesis "Strategies to predict patient-specific outcomes after endovascular aneurysm repair" on December 5, 2024 . What is the main focus of the thesis?

Business magnate and honorary doctor at Karolinska Institutet Fredrik Lundberg is donating SEK 25 million for a continued investment in cardiovascular research. This is the fifth large donation made since 2007 by Lundberg, whose engagement has enabled research that has greatly improved therapeutic and surgical methods for cardiovascular diseases.

In a new study published in the European Heart Journal, researchers at Karolinska Institutet show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions to cause a stroke or heart attack. The new knowledge can be used to improve the risk assessment and treatment of patients with atherosclerosis in the future.

Common cardiovascular drugs are linked to a lower risk of dementia in older age, according to a new study from Karolinska Institutet published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

A new study from Karolinska Institutet shows that heart failure mortality has decreased in Sweden over the last 20 years. The study has been published in the European Journal of Heart Failure.

Hi Andreas Rydell doctoral student at the Division of Family Medicine and Primary Care. On November 7 you will defend your thesis "Impaired lung function and the development of cardiovascular disease". What is the main focus of the thesis?

Ulf Hedin, Professor of Vascular Surgery at Karolinska Institutet, and Christian Gasser, Professor of Biomechanics at KTH, are jointly leading a new research project focusing on technology to enable individual treatment of fatal forms of stroke and carotid artery disease. The project is now being granted research funding of SEK 4.5 million per year for five years by MedTechLabs.

A new donation professorship in prevention is being established at Karolinska Institutet. It will be named Prince Daniel's Professorship in Cardiovascular Prevention and will be awarded to researcher and obstetrician Ylva Trolle Lagerros, who took up the position on 1 October. The aim is to reduce the incidence of cardiovascular diseases in Sweden.

Researchers at Karolinska Institutet have identified a new potential risk marker for cardiovascular disease in women. A new study shows an association between low levels of an anti-inflammatory antibody and the risk of heart attack and coronary heart disease. The study is published in the Journal of American College of Cardiology.

The Swedish Society of Medicine (SLS) awards researchers John Pernow and Aida Collado Sánchez at Karolinska Institutet with the Alvarenga Prize 2024. The laureates are rewarded for a research article on a study that shows a new cause behind vascular complications in type 2 diabetes and possible future treatment to prevent this.

Severe, lasting hot flushes during menopause are associated with atherosclerosis in the coronary artery, new research from Karolinska Institutet and Linköping University and published in the Journal of the American Heart Association reveals.

Finding out who falls ill and why is essential to preventative action. Jette Möller conducts epidemiological research on our major health issues – cardiovascular disease, mental ill-health and injuries. Meet one of Karolinska Institutet's new professors who will participate in this year's installation ceremony at Aula Medica on 3 October.

Certain genetic variants that have previously been linked to the lung disease COPD can explain reduced lung function already in children and adolescents, according to researchers at Karolinska Institutet. The results are presented in the Lancet's sister journal eClinicalMedicine together with fifteen other European research centres.

A new study shows that women lose more years of life after a heart attack than men. A 50-year-old woman with a large heart attack loses an average of 11 years, while an 80-year-old man with a small heart attack loses an average of 5 months of life. The study was led by researchers at Karolinska Institutet and Danderyd Hospital and the results have been published in the journal Circulation.

The use of new nicotine products such as white snus and e-cigarettes has increased significantly among young people in Sweden. Marketed as tobacco-free, these products often contain high levels of nicotine and are flavoured in ways that attracts new target groups. But what do we really know about the risks?

Ljubica Matic and Anton Razuvaev from the Vascular Surgery Group at the Department of Molecular Medicine and Surgery, Karolinska Institutet, have been awarded with the Swedish Heart-Lung Foundation 120 years Jubilee grant for their project that aims to reveal novel mechanisms and develop therapeutic targets and biomarkers for personalised treatment in lower limb peripheral arterial disease.

On June 3rd and 4th, international vascular surgeons, scientists and trainees gathered in the Sune Bergström Auditorium to present and discuss translational vascular research. This was the third time the Vascular Surgery group at the Department of Molecular and Medicine, Karolinska Institutet, hosted the meeting, in 2020 in a virtual format, in 2022 and this year in the welcoming venue of Bioclinicum.

Inflammatory bowel disease (IBD) is associated with a slightly increased risk of heart failure up to 20 years after diagnosis, according to a comprehensive registry study from Karolinska Institutet published in the European Heart Journal.

Jacob Hollenberg, Mattias Ringh and Leif Svensson, at the Department of Clinical Research and Education, Södersjukhuset at Karolinska Institutet, are awarded for using innovative technology to develop an outstanding app and method, which increases the chance of survival for people who have suffered a cardiac arrest .

Researchers from the Vascular Surgery Group at the Department of Molecular Medicine and Surgery, Karolinska Institutet, have teamed up with 20 clinical research centres, universities, professional associations, SMEs and non-profit representative organisations of civil society in a new EU Horizon Europe project NextGen, aiming to develop the next generation tools for genome-centric multimodal data integration in personlised cardiovascular medicine.

For heart attack patients, treating only the coronary artery that caused the infarction works just as well as preventive balloon dilation of the other coronary arteries, according to a new large study by researchers at Karolinska Institutet and others. The results are published in the New England Journal of Medicine.

Half of all patients discharged from hospital after a heart attack are treated with beta-blockers unnecessarily. This is according to a new study published in the New England Journal of Medicine.
"I am convinced that this will influence future practice," says Tomas Jernberg, Professor at Karolinska Institutet and lead researcher of the study.

The Swedish Kidney Foundation (Njurfonden) distributes more than SEK 7 million to research into kidney diseases. This is the largest sum since the fund was established and is awarded to 40 researchers, 19 of whom are active at Karolinska Institutet. The grants go to research related to chronic kidney disease, dialysis and transplantation.

Height and weight charts have been used for decades to monitor child development. A paper in The Lancet now presents a new application that enables healthcare professionals to keep a regular check on the development of one of the body’s most vital organs – the lungs. Lung Function Tracker is the product of an international collaboration involving researchers at KI, the University of Barcelona, Spain, the Imperial College London, the UK, and the University of Melbourne, Australia.

A new study from Karolinska Institutet reveals that immune cells in the liver react to high cholesterol levels and eat up excess cholesterol that can otherwise cause damage to arteries. The findings, published in Nature Cardiovascular Research, suggest that the response to the onset of atherosclerosis begins in the liver.

The Department of Molecular Medicine and Surgery and the Faculty of Medical Sciences of the University of Kragujevac in Serbia has now formalized a multi-year cooperation by signing a Memorandum of Understanding.

In December, Kenneth Chien is leaving his professorship in cardiovascular research after ten years at Karolinska Institutet. He will now devote himself wholeheartedly to developing new mRNA therapies in the biotechnology industry.

We congratulate Daniel C Andersson, Johanna Lanner, Jon Lundberg, Carl Johan Sundberg, and Eddie Weitzberg, researchers at the Department of Physiology and Pharmacology (FyFa), for securing grants from the Swedish Heart Lung Foundation in 2023. In total SEK 5,9 million has been awarded the researchers at FyFa.

A new laboratory for MRI examinations was recently inaugurated at Karolinska University Hospital in Huddinge. The purchase of a new MRI scanner, following a donation from the Erling Persson Foundation, creates completely new opportunities for the Stockholm Region and Karolinska Institutet for both doctors and researchers.

Researchers at Karolinska Institutet have evaluated the possibility of alerting drones equipped with automated external defibrillators (AED) to patients with suspected cardiac arrest. In more than half of the cases, the drones were ahead of the ambulance by an average of three minutes. In cases where the patient was in cardiac arrest, the drone-delivered defibrillator was used in a majority of cases. The results have been published in the journal The Lancet Digital Health.

It is common for middle-aged women with suspected myocardial infarction to be diagnosed with broken heart syndrome instead, which is triggered by stress and grief. Per Tornvall hopes that his research will result in more people receiving the correct diagnosis and fewer people suffering a relapse. He is now testing to see if internet CBT may help to heal the heart.

The Swedish Society of Medicine (SLS) annually awards SEK 100,000 as a prize to a particularly deserving younger researcher who has applied for and been awarded SLS project grants. This year, the prize goes to Bahira Shahim, resident physician in cardiology and researcher at the Department of Medicine Solna.

Although a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. But how it goes about doing this has long been unclear. Researchers at Karolinska Institutet in Sweden now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form. Their findings are presented in the journal Nature Chemical Biology.

Cardiogenic growth factors play important roles in heart development and in a new study published in the scientific paper Nature Communications from researchers at Karolinska Institutet shows how stem cell therapeutics and mRNA technology are beginning to converge offering major improvements in vascularization, survival, expansion, differentiation, and ultimately the function of human stem cell grafts.

Low concentrations of air pollutants are associated with poorer health, and previous research has found a link between air pollution and dementia risk. Researchers at Karolinska Institutet, among others, have now investigated this connection. The study, published in the journal Neurology, contributes to a better understanding of the biological mechanisms that might explain why air pollution seems to increase the risk of developing dementia.

Cardiovascular disease is one of the most common causes of death in Sweden and in the world. Researchers at Karolinska Institutet, among others, have now found that artificial intelligence seems to play a role in identifying the risk of cardiovascular disease. The study, published in Cardiovascular Research, may in the future lead to more accurate diagnostic methods.

Online cognitive behavioral therapy (CBT) shows promising effects on quality of life, as well as reduced healthcare consumption for patients with paroxysmal (i.e., intermittent) symptomatic atrial fibrillation, according to a new study in the Journal of the American College of Cardiology. According to the researchers, this is the world's first randomized controlled trial of CBT for patients with atrial fibrillation (AF).

In the largest survey to date, researchers at Karolinska Institutet have studied how diseases of the aortic valve affect prognosis in patients with various types of heart failure. The study was published in the European Journal of Heart Failure. Shared first authors are sisters Angiza and Bahira Shahim, who also presented the results of the study at the Heart Failure International Conference in Prague.

Antti Siika at the Vascular Surgery research group, Department of Molecular Medicine and Surgery, will defend his thesis "Biomechanical and Morphological Aspects of Abdominal Aortic Aneurysm Growth and Rupture" on April 28th, 2023.

Main Supervisor is Joy Roy.

Researchers at Karolinska Institutet have investigated how preterm birth and foetal growth are related to the risk of atrial fibrillation up to middle-age. The study, which is published in JAMA Pediatrics, shows that being born preterm or large for gestational age was associated with increased risks of atrial fibrillation later in life. Being small for gestational age at birth was only associated with an increased risk of atrial fibrillation up to the age of 18.

The 5D Heart Patch Project, led by Prof Kenneth Chien, has identified human ventricular progenitor (HVP) cells that can create self-assembling heart grafts in vivo. The research has the potential to offer hope to millions of people suffering from heart failure.

The risk of developing cardiovascular disease is lower in people with obesity who have a genetic predisposition for high BMI than people with obesity influenced mainly by environmental factors such as lifestyle, researchers from Karolinska Institutet report in eClinicalMedicine.

Acetylcholine regulates blood flow, but the source of blood acetylcholine has been unclear. Now, researchers at Karolinska Institutet have discovered that certain T cells in human blood can produce acetylcholine, which may help regulate blood pressure and inflammation. The study, which is published in PNAS, also demonstrates a possible association between these immune cells in seriously ill patients and the risk of death.

Three professors at Karolinska Institutet – Gonçalo Castelo-Branco, Maria Eriksson and Björn Högberg – have been awarded ERC Advanced Grants, one of the most prestigious and competitive EU funding schemes. The funds, totaling more than 8 million euros, will support the use of innovative basic research methods to further our understanding of disease mechanisms and the tiniest building blocks of DNA.

Mareia Talvitie at the Vascular Surgery research group, Department of Molecular Medicine and Surgery, will defend her thesis "Abdominal aortic aneurysms : sex and gender disparities in surveillance, treatment and outcome" on March 31st, 2023.
Main Supervisor is Rebecka Hultgren.

A clinical study by researchers at Karolinska Institutet and Karolinska University Hospital shows that the hunger hormone ghrelin can increase the heart’s pump capacity in patients with heart failure. The results have been published in the European Heart Journal.

Thanks to donations from numerous actors, Karolinska Institutet is now able to create a new professorship in prevention medicine. The professorship is named after its patron, HRH Prince Daniel.

Patients with heart failure often suffer from co-morbidities, which places a great strain on the healthcare services, a multinational study published in Heart reports. The researchers, who are based at Karolinska Institutet, identify an urgent need to improve risk management of the disease.