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An article in The Conversation written by a KI researcher broke a record in the number of readers. Associate Professor Karin Modig's article on centenarian biomarkers received almost 2.4 million reads and was translated into several languages.
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The eastern mediterranean region is currently facing a brewing health crisis, brought on not least by the war in Gaza. The danger of spread of infectious diseases means that effective epidemiological surveillance and action is key. To assist in these efforts, the Centre for Health Crises has seconded epidemiologist Moa Herrgård via our membership in WHO’s Global Outbreak Alert and Response Network (GOARN).
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No increased risks for babies, and for some serious neonatal complications lower risks. This is the result of the largest study to date on the safety of newborn babies whose mothers were vaccinated against COVID-19 during pregnancy. The study is a collaboration between Swedish and Norwegian researchers and is published in the journal JAMA.

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Suicide is one of the leading causes of death in young persons in Sweden and globally. The last decades have seen an increasing proportion of the youth population engaging in university level education. The university period usually coincides with other important life events such as moving away from home. Early adulthood is furthermore a period when severe mental disorders, such as bipolar disorder and schizophrenia, may become symptomatic.
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On January 25, a method support day was organized by Clinicum to introduce researchers to the coordinated method support offered to researchers at KI and Region Stockholm. The meeting was held in the Sune Bergström Hall at Karolinska University Hospital.
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Asthma and cystic fibrosis are diseases which affect the lungs of children and adults. Previous research has shown that genetic and environmental factors during pregnancy and early childhood can contribute to the way children and young adults are affected by these lung diseases.
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An investigation conducted by researchers at Karolinska Institutet has led to a discovery in breast cancer diagnostics and treatments that could reshape screening programs and clinical approaches. The study, published in JAMA Oncology, unravels the impact of rare genetic variants on interval breast cancers, providing new insights into tailored screening strategies.
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Recent and unintentional weight loss is associated with an increased risk of a cancer diagnosis in the coming year, according to a new study in JAMA. Researchers from Karolinska Institutet and others behind the study urge healthcare professionals and the public to be vigilant about sudden and unintentional weight loss.
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Chronic kidney disease (CKD) affects over 10% of adults worldwide. Mental health is an important yet under-recognized issue in patients with CKD. Depression is common and related to poor prognosis in CKD patients, but previous research has primarily focused on dialysis patients, leading to an insufficient understanding of depression in earlier stages of CKD.
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Major Depressive Disorder (MDD) is a common mental disorder, affecting around 20% of the population worldwide. Several causes that can lead to MDD, and patients display a wide range of symptoms as well as responses to treatments. This diversity makes it challenging to pinpoint the root causes, understand the underlying mechanisms, and tailor treatments effectively. Suicide is a pressing public health concern, impacting not only individuals living with MDD but also the general population.
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Some people seem to age faster than others. Whilst “chronological age” describes the time that has passed since someone was born, “biological age” tells us how old their body appears. We can measure biological age using standard clinical data such as blood test results and blood pressure readings. Alternatively, we can measure biological age using information about DNA methylation, which are marks on our DNA that change over time.
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Eating disorders are debilitating conditions characterized by dysregulated eating and/or weight-control behaviors leading to significant impairment of psychosocial functioning and/or physical health. Both environmental factors and variation in multiple genetic variants influence eating disorder etiology and maintenance.
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A large proportion of patients who start taking ADHD medication, especially young adults, stop within the first year. However, people who use ADHD medicine for a long time and in higher-than-average doses seem to have a higher risk of some cardiovascular diseases. This is according to two new studies led by researchers from Karolinska Institutet and published in The Lancet Psychiatry and JAMA Psychiatry.
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Gambling addiction can increase the risk of long-term sick leave for several years, according to a new study published in Psychological Medicine. Researchers from Karolinska Institutet behind the study point to the need to detect people with gambling addiction in time to avoid financial and health problems.
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There is a well-known relationship between good physical fitness at a young age and a lower risk of cardiovascular disease later in life. However, when researchers adjusted for familial factors by means of sibling analysis, they found a weaker association, although the link between high body mass index (BMI) and cardiovascular disease remained strong. The study, which was conducted by researchers from Karolinska Institutet and other universities, is published in JAMA Network Open.
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Frailty is an age-related state of physiological decline and is a strong predictor of disability and mortality. Researchers are trying to improve our understanding of the biology of frailty and to find ways of identifying frail older adults with the aim to improve individualized management of frailty.
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A new thesis from Karolinska Institutet advocates end-of-life care that prioritizes the highest possible quality of life, avoids unnecessary or preventable risks and respects patient wishes.
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Meet Johan Askling, research group leader at the Division of Clinical Epidemiology (KEP), Department of medicine, Solna.
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Audience: Medarbetare
Medicin, Solna, KEP
A collaborative study involving researchers from Karolinska Institutet has charted the prevalence of severe physical symptom burden amongst Scandinavians for up to two years after a SARS-CoV-2 infection. Most affected were people who had a severe COVID-19 infection, while the researchers found no elevated prevalence of long COVID in those who had never been bedridden. The study is published in The Lancet Regional Health – Europe.
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In recent years, there have been rapid advancements in the field of computational pathology, which refers to the application of computational methods in pathology workflows. Traditional pathology involves the study of diseases by examining tissues, organs, and bodily fluids. In computational pathology, digital pathology images are analyzed using computer algorithms to extract meaningful information.
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A new thesis from Karolinska Institutet focuses on cancer prevention by investigating the factors and outcomes associated with false-positive mammography recalls, a fairly common event where women are called back for additional tests after an initial screening, but no cancer is detected during the follow-up. A second aim of the thesis was to further our understanding of the association between breast cancer risk factors in women and cancer risk among their relatives, particularly sisters.
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Mania is a possible but rare side effect of treatment with antidepressant medication in adults, but little has previously been known of this risk in depressed children and adolescents. A newly published paper in JAMA Psychiatry investigated this, finding no evidence of mania/hypomania induced by antidepressants by 12 weeks after treatment initiation. However, caution is necessary in treatment for children with more severe depression or where a parent has bipolar disorder.
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Olof Stephansson's research group receives Alvarenga's prize 2023 for the article: "Risk of postpartum hemorrhage with increasing first stage of labor duration" with the motto "How long it takes to give birth can affect the risk of bleeding". The prize is awarded by the Swedish Society of Medicine (Svenska Läkaresällskapet).
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Childhood-onset type 1 diabetes (onset <age 18) and neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and intellectual disability, globally represent substantial health challenges. The conditions also pose substantial challenges to the individuals, their families, and healthcare systems.
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Type 1 diabetes is an autoimmune disease, often with onset during childhood, that requires lifelong insulin therapy due to the loss of pancreatic beta-cells.
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Close relatives of people with metabolic-associated fatty liver disease have a higher risk of developing liver cancer and dying from liver-related diseases, according to a national study from Karolinska Institutet published in The Journal of Hepatology. This means that family members could also benefit from the lifestyle advice that is currently only given to patients, the researchers conclude.
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CLINICUM is part of the region-wide initiative that aims to strengthen the quality of clinical and translational research. In its entirety, CLINICUM consists of a central function and seven nodes which represent the care provider organizations in Region Stockholm and SLSO. The nodes' activities aim to offer scientific advice and to provide methodological support and guidance in the planning and execution of research projects.
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Audience: Medarbetare
Mikrobiologi, tumör- och cellbiologi, Medicinsk biokemi och biofysik, Medicinsk epidemiologi och biostatistik, Fysiologi och farmakologi, Neurovetenskap, Cell- och molekylärbiologi, Laboratoriemedicin, Klinisk vetenskap, intervention och teknik, Biovetenskaper och näringslära, Klinisk forskning och utbildning, Södersjukhuset, Kliniska vetenskaper, Danderyds sjukhus, Klinisk neurovetenskap
It is quite common that individuals who have one psychiatric condition, also qualify for other psychiatric conditions. This observation questions the conventional belief that different diagnoses are independent, and instead implies the possibility of a set of factors that increases risks for several types of mental health problems.
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The podcast Riskzonen, featuring well-known KI staff members Mattis Öberg and Emma Frans, is back with a new season! The four episodes were released in May and June, and after a brief break over summer, more episodes will now be released each Monday, starting on 28 August. Each episode features the topic health crisis, in one way or another, ranging from relief efforts in war to antibiotic resistance. The new season is made in collaboration with the Centre for Health Crises.
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Low concentrations of air pollutants are associated with poorer health, and previous research has found a link between air pollution and dementia risk. Researchers at Karolinska Institutet, among others, have now investigated this connection. The study, published in the journal Neurology, contributes to a better understanding of the biological mechanisms that might explain why air pollution seems to increase the risk of developing dementia.
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Many men in northern Europe over the age of 60 suffer from the so-called Viking disease, which means that the fingers lock in a bent position. Now researchers at Karolinska Institutet, together with colleagues, have used data from over 7,000 affected individuals to look for genetic risk factors for the disease. The findings, which have been published in Molecular Biology and Evolution, show that three of the strongest risk factors are inherited from Neanderthals.
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Nasopharyngeal carcinoma (NPC) is a type of cancer that occurs in the nasopharynx, which is located behind the nose and above the back of the throat. NPC has a geographically skewed distribution worldwide, with high incidence rates in East and Southeast Asia. NPC is difficult to detect early, and treatment usually involves radiation therapy, chemotherapy or a combination of the two.
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Older autistic adults have a significantly higher risk of injury, especially self-inflicted, and physical conditions such as type 2 diabetes, anaemia, heart failure and COPD. This is according to a large-scale registry study from Karolinska Institutet published in The Lancet Healthy Longevity.
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In a nationwide Swedish study involving more than 12,000 individuals with nonalcoholic fatty liver disease (NAFLD), researchers found a significantly increased risk of severe infections requiring hospital admission. The study was published in Clinical Gastroenterology and Hepatology.
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In a nationwide Swedish study of more than 12,000 patients with microscopic colitis (MC), researchers from Sahlgrenska University Hospital and Karolinska Institutet found an increased risk of acute pancreatitis compared to the general population. The study has been published in The American Journal of Gastroenterology.
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The award is presented by the Pediatric research foundation ”Stiftelsen Barnforskningen” at the Astrid Lindgren Children’s hospital.
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Audience: Medarbetare
Medicinsk epidemiologi och biostatistik
The Strategic Research Program in epidemiology (SFOepi) at Karolinska Institutet now announces funding for three different types of grants; Consolidator Grant for junior researchers, Junior Scholar Grants in Epidemiology or Biostatistics and small grants.
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Audience: Medarbetare
Medicinsk epidemiologi och biostatistik, Medicin, Solna, Global folkhälsa, Neurovetenskap
Breast cancer is the most common cancer among women and the likelihood of surviving the disease is higher if the cancer is detected early and the tumour is relatively small and not very aggressive.
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Why is it that certain mammals have an exceptional sense of smell, some hibernate, and yet others, including humans, are predisposed to disease? In a major international research project where researchers at Karolinska Institutet participated, has surveyed and analysed the genomes of 240 different mammals. The results, now published in 11 articles in the journal Science, shows which regions have important functions in mammals.
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Breast cancer is the most common cancer affecting women and many women are being treated to prevent the cancer from returning, for example with adjuvant hormone therapy. This therapy is prescribed as a once-a-day pill for estrogen receptor-positive breast cancer patients (around 80% of all cases) for a duration of at least five years.
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In a Swedish systematic review published in Acta Paediatrica, researchers from Karolinska Institutet, University of Gothenburg, Umeå University, and the Swedish agency for health technology assessment and assessment of social services, mapped the current knowledge of hormonal treatment in youths <18 years with gender dysphoria.
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In a nationwide Swedish study of 207 births to women with an earlier diagnosis of colorectal cancer (CRC), researchers found an increased risk of both maternal and neonatal adverse outcomes. The study was published in eClinicalMedicine and is a collaboration between Washington University in St Louis and Karolinska Institutet.
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Predictions are becoming more and more a part of our lives, and they are becoming increasingly useful in medical science as the science evolves. Increased understanding of disease and its treatments allows us to use predictions based on predictive biomarker signatures to optimize treatment outcomes for increasingly specific subject groups.
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The risk of developing cardiovascular disease is lower in people with obesity who have a genetic predisposition for high BMI than people with obesity influenced mainly by environmental factors such as lifestyle, researchers from Karolinska Institutet report in eClinicalMedicine.
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A Scandinavian collaboration led by KI researchers shows that of individuals treated in specialist care for major depressive disorder (MDD), many have a severe prognosis, for instance experiencing recurrence, developing other psychiatric disorders, requiring inpatient treatment, and some even dying by suicide. This research was based on 273,000 individuals with MDD in Sweden, Denmark, and Norway. The findings are published in Lancet Regional Health Europe.
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In a new thesis from Karolinska Institutet, the focus was on the use of multiomics data in the discovery of disease signatures.
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Women with mental illness, neuropsychiatric disability, or substance abuse are less likely to go for gynaecological smear tests for cervical cancer and run more than twice the risk of developing the disease. The findings are presented in Lancet Public Health by researchers from Karolinska Institutet, who stress the importance of proactively approaching these women as a preventative measure against cervical cancer.
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Competing risks and multi-state models allow us to study complex disease settings and answer composite research questions and should be used more widely in epidemiology.
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A Swedish study which followed more than 450,000 individuals after lower or upper gastrointestinal biopsy, suggests that symptoms of IBD (inflammatory bowel disease) may start significantly before disease shows up on biopsy. The results were published in the open access journal PLOS Medicine on Feb 23.
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Women with rheumatic diseases are at greater risk of complications during pregnancy and childbirth, but for women with axial spondyloarthritis the risks have decreased over the last ten years, according to a register study from Karolinska Institutet. This decrease coincided with an increased use of biologic drugs during the same period. The study was published in The Lancet Rheumatology.
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KI webbförvaltning
09-06-2023