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13 January, 2023Protein movement reveals brain tumour's weak spot
Proteins do not have a single shape, but are more like dynamic robots. But – how do they actually move? And what does this tell us about their function? Laura Orellana describes the movement of proteins using computer simulations – and has discovered a new drug target for glioblastoma brain tumours.
5 December, 2022MBB Frontier Teaching Awards
To further strengthen our teaching, we are now announcing up to three MBB Frontier Teaching Awards, which are aimed at identifying, recruiting, and supporting dedicated personnel at MBB who have a special interest and skill in engaging in the further development of our teaching. Apply at the latest by 15 December.
Medicinsk biokemi och biofysik
11 April, 2022Hugo Theorell Prize in biophysics to Katja Petzold
Katja Petzold has been awarded the Hugo Theorell Prize in biophysics 2022. The focus in her lab is to study structural changes in RNA – e.g. the RNA in the ribosome – and to develop methods for this purpose.
A new study shows how antibodies select the antigens that they bind to, as they navigate the surface of pathogens like coronaviruses. Researchers from KTH Royal Institute of Technology and Karolinska Institutet have created a model that suggests the migration of these pathogen hunters may be akin to the random movements of a child playing on stream laden with stepping stones.
7 December, 2020New fundamental knowledge of the “abdominal brain”
Researchers at Karolinska Institutet have succeeded in mapping the neuron types comprising the enteric nervous system in the intestine of mice. The study, which is published today in the scientific journal Nature Neuroscience, also describes how the different neurons form during fetal development, a process that follows different principles to brain neurons.
2 November, 2020New analysis method can lead to better cancer drugs
While proteins on the surface of cells are the targets for most drugs, refined methods are needed to analyse how these membrane proteins are organised. Researchers at Karolinska Institutet have developed a new DNA-based analytical method that could contribute to the development of future drugs for breast and other cancers. The study is published in Nature Nanotechnology.
A study lead by KI researcher and SciLifeLab Fellow Simon Elsässer elucidates a new flavour of heterochromatin, used by embryonic stem cells to silence ‘parasitic’ DNA-elements within the context of their highly dynamic pluripotent chromatin. The study was recently published in Nature Communications.
23 June, 2020Illuminating cell surface receptors
Cell surface receptors are essential for the communication of human cells. Simon Elsässer’s lab has developed a method to study these proteins on living cells. With very subtle alterations the method allows to label receptors with two different fluorescent probes in defined positions, as the authors show in Cell Reports. This can give detailed insights in how the conformation of a receptor changes as a result of for example drug binding, in the natural setting of the cell membrane.
Research from Karolinska Institutet published today in Nature shows that an RNA molecule involved in preventing tumour formation can change its structure and thereby control protein production in the cell. The finding can have important clinical implications as it opens for new strategies to treat different types of cancer.
7 January, 2020Senior Professor Arne Holmgren has died
Arne Holmgren, Senior Professor at Karolinska Institutet, died on January 6, 2020, 79 years old. Dr. Holmgren was widely known as one of the groundbreaking scientists establishing the rapidly growing field of redox biology.
3 October, 2019Breakthrough in sex-chromosome regulation
Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage and could be important for the emerging field of regenerative medicine. The study is published in Nature Structural and Molecular Biology.