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After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart. This is according to a new study from Karolinska Institutet published in the journal Circulation.
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New research reveals that scar formation after spinal cord injuries is more complex than previously thought. Scientists have identified two types of perivascular cells as key contributors to scar tissue, which hinders nerve regeneration and functional recovery. These findings, published in Natural Neuroscience, are also relevant for other brain and spinal cord injuries and could lead to targeted therapies for reducing scarring and improving outcomes.
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For the 12th Tissue and Motion Conference, Karolinska Institutet researchers returned to Djurönäset Hotel on 16th-17th April 2024 to discuss research, network, and enjoy Stockholm’s archipelago.
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Following a hiatus of 3 years due to Covid-19, the KI Research Network Tissue and Motion rose to the occasion of hosting the 11th Tissue and Motion conference, which was held at the Djurönäset Hotel on 9th – 10th November 2022.
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Four research projects coordinated from Karolinska Institutet have been awarded project grants by Knut and Alice Wallenberg Foundation (KAW) in 2022. This means that, over SEK 135 million are allocated to KI research in the fields of immunology, neuroscience, and stem cell biology.
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Heart progenitors spontaneously regenerate cardiac muscle via a tight junction “honeycomb” in salamanders. Whether there are endogenous adult heart progenitors that can replenish damaged muscle cells remained controversial.
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Spinal cord injury often leads to permanent functional impairment. In a new study published in the journal Science researchers at Karolinska Institutet show that it is possible to stimulate stem cells in the mouse spinal cord to form large amounts of new oligodendrocytes, cells that are essential to the ability of neurons to transmit signals, and thus to help repair the spinal cord after injury.
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A multiple organ-on-chip platform developed by researchers at KTH Royal Institute of Technology, Karolinska Institutet and Harvard University could drastically accelerate drug testing. The technology, described today in Nature Biomedical Engineering, provides accurate predictions of drug effects prior to clinical testing.
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Researchers have developed a new variant of the gene editing technique CRISPR-Cas9 that has the potential to increase precision during gene therapy in humans. The new variant reduced unintended changes in DNA compared to its wildtype, suggesting it could play a role in gene therapies that require high precision. The study by researchers from Karolinska Institutet’s Ming Wai Lau Centre of Reparative Medicine in Hong Kong is published in the journal PNAS.
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