News archive

A new study published in BMC Public Health, shows that screening in schools can improve psychotic symptoms in adolescents. The study is partly produced by researcher at the National centre for suicide research and prevention at Karolinska Institutet.

Dads are more likely to feel depressed when their kids are toddlers if their coparenting relationships are poor in the months after birth, a new study by researchers at Karolinska Institutet in Sweden shows. The findings are published in the Journal of Affective Disorders.

Researchers at Karolinska Institutet have conducted a pioneering study analysing internet-delivered anonymous cognitive behavioural therapy (CBT) for people who view images or videos of children being sexually abused. The participants, who were mainly recruited via forums on the encrypted part of the internet called Darknet, reported less use of such material after therapy. The study is published in the journal Internet Interventions.

Professor Danuta Wasserman, the fouder and current head of department for National Centre for Suicide Research and Prevention of Mental Ill-Health, was given the honor to give the opening keynote lecture at the 9th World Congress on Women's Mental Health.

Schizophrenia patients have fewer connections between nerve cells. This is believed to be caused by genetic risk variants leading to an excessive elimination of nerve cell connections by the immune cells of the brain. Researchers at Karolinska Institutet now report in Nature Communications that the levels of protein from the relevant risk gene are elevated in first-episode patients and that inflammation further increases the expression of the risk gene. 

Autistic young men and women are more affected by psychiatric conditions and have an increased risk of being hospitalized as a result of their mental illness compared with non-autistic people. Autistic women are particularly vulnerable. This is shown by researchers from Karolinska Institutet in a study published in JAMA Psychiatry.

We know that lifestyle affects health. But even factors that you cannot control have an influence. Here are six examples.

Deep grief has both mental and physical health consequences for the sufferer that can take decades to heal. People can even die of grief. It is therefore important to try to alleviate the effects of severe grief, something that we in Sweden aren’t particularly good at.

Both children with type 1 diabetes and their closest family members are at increased risk of mental health problems compared with those without the disease, according to a large study by researchers at Karolinska Institutet published in the journal Diabetes Care. The findings underscore the need for psychological consulting for both children and their families in diabetes care.

Patient-initiated brief admission as a complement to outpatient psychiatric care is appreciated by nurses and patients, and can reduce levels of anxiety in people with emotional instability and self-harm, a new thesis from Karolinska Institutet reports.

Researchers at Karolinska Institutet in Sweden might have found an explanation for why people with self-injury behaviour generally feel less pain than others. The key seems to be a more effective pain-modulation system, a discovery that can benefit people seeking help for their self-harm. The findings are published in the journal Molecular Psychiatry.

About half of the Swedish population feels a strong climate worry. This is normal because the climate threat is real, says researcher Fabian Lenhard, who is starting a study on climate change. The research project will be attempting to channel worry about climate change into sustainable development.

Six predictors could help determine the amount of lithium needed to treat patients with bipolar disorder, according to a large study led by researchers at Karolinska Institutet in Sweden. The study, published in the journal The Lancet Psychiatry, also pinpoints genetic markers that seem to influence how quickly the body eliminates lithium from its system.

Screen time is often associated with poor health in young people, but it is more complicated than that, say researchers. We are affected, but differently and not just negatively. What we do on our phones – and what we do when we are not using them – also plays a role in our well-being.

People who were bedridden for at least a week due to COVID-19 were more likely to experience anxiety and depression for up to 16 months after the infection, compared with those who only had mild symptoms or were never infected. That is according to a large study based on data from six countries and conducted by an international team of researchers including those from Karolinska Institutet and the University of Iceland. The findings are published in The Lancet Public Health.

Sexual and gender-based harassment in the workplace can contribute to the development of mental ill-health requiring treatment with antidepressants and anti-anxiety medication, a study from Karolinska Institutet in Sweden published in the journal Occupational and Environmental Medicine reports.

KI researcher Lu Yi has been awarded 1.5 million euros from the prestigious European Research Council Starting Grants. The funds will go toward research on different subtypes of depression with the goal of finding treatments that work for more people.

What does it mean to admit yourself as a patient? Maria Smitmanis Lyle, a PhD student at the Department of Clinical Neuroscience and Coordinator at the Centre for Psychiatry Research, who researches self-admission for children and adolescents, explains.

Last week the Department of Global Public Health in cooperation with War Child Sweden and the Swedish Red Cross University College hosted a guest lecture with Professor Mark Jordans. In his presentation, Professor Jordans presented interventions and evidence on how to promote the mental health and well-being of children in settings made fragile by armed conflicts.

Critical illness and intensive care can affect patients and their families long after discharge from hospital. In her doctoral thesis at Karolinska Institutet, intensive care nurse Gisela Vogel has studied different strategies used to manage critical illness and care in an intensive care unit, from when the patient becomes critically ill until the return to everyday life.

Never before have so many people been displaced by war and poverty. Such change and loss can leave deep psychological scars. A new thesis by Doctor Maria Sundvall at Karolinska Institutet is based on surveys and interviews with asylum seekers and refugees in Sweden about their encounters with the psychiatric and primary care services. The results of her studies can make a significant contribution to the dialogue between migrants, clinics and authorities.

Patients with bipolar disorder who experience manic episodes are more likely to show abnormal brain changes over time, according to one of the largest longitudinal brain imaging studies in its field to date. The study, led by researchers at Karolinska Institutet and University of Gothenburg in Sweden, also confirms links between bipolar disorder and accelerated brain ventricle enlargement. The findings are published online in the journal Biological Psychiatry.

Traumatic experiences such as assault or a road accident can give rise to nightmares, flashbacks and other mental reactions, and accessible therapy is needed to prevent exacerbation of the problems. Researchers at Karolinska Institutet have now completed what could be the largest evaluation to date of internet-delivered trauma-focused CBT (iCBT-T) for people who have recently experienced trauma. The study, which is published in Psychological Medicine, shows promising results.

The discovery that the anaesthetic ketamine can help people with severe depression has raised hopes of finding new treatment options for the disease. Researchers at Karolinska Institutet have now identified novel mechanistic insights of how the drug exerts its antidepressant effect. The findings have been published in the journal Molecular Psychiatry.

University students in Stockholm reported no tangible differences in depression, anxiety or stress during the first few months of the COVID-19 pandemic, a longitudinal study at Sophiahemmet University and Karolinska Institutet finds. The study is published today in Scandinavian Journal of Public Health.

The common skin disease atopic eczema (AE) impacts heavily on the life quality and general health of sufferers. Researchers at Karolinska Institutet have now evaluated its treatment with internet-delivered cognitive behavioural therapy (iCBT). The study suggests that patients feel better after iCBT compared with a control group who received only traditional treatment. The results, which are published in JAMA Dermatology, might eventually make important care available to a large patient group.

Social anxiety disorder can cause considerable suffering in children and adolescents and, for many with the disorder, access to effective treatment is limited. Researchers at Centre for Psychiatry Research at Karolinska Institutet and Region Stockholm have now shown that internet-delivered cognitive behavioural therapy is an efficacious and cost-effective treatment option. The study is published in the journal JAMA Psychiatry.

New research at Karolinska Institutet suggests a link between psychosis and a genetic change that affects the brain's immune system. The study published in Molecular Psychiatry may impact the development of modern medicines for bipolar disorder or schizophrenia.

Obsessive-compulsive disorder (OCD) in children and adolescents is associated with impaired education and worse general health later in life. Access to specialist treatment is often limited. According to a study from Centre for Psychiatry Research at Karolinska Institutet and Region Stockholm, internet-delivered cognitive behavioural therapy (CBT) can be as effective as conventional CBT. The study, published in the prestigious journal JAMA, can help make treatment for OCD more widely accessible.

Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells. A brain imaging study at Karolinska Institutet now shows that the average level of the serotonin transporter increased in a group of 17 individuals who recovered from depression after cognitive behavioural therapy. The results are published in the journal Translational Psychiatry.

Researchers at the Centre for Psychiatry Research at Karolinska Institutet have completed a large study evaluating a screening instrument for assessing the risk of suicide in connection with a visit to an emergency psychiatric clinic. The researchers found a link between screening score and suicide risk a short time after the emergency visit. The study is published in the journal Psychological Medicine.

The number of suicides decreases among adults, but increases among young people. Schools often ask how to get better at talking about suicide and mental health with their students. Therefore, Suicide Zero, Mind, SPES and NASP, who stand behind the project Stör Döden, have produced an educational material for teachers in high school.

In a recent study published in Psychological Medicine, researchers from Karolinska Institutet showed that different types of screen-use may have contrasting effects on adolescent mental health; some are detrimental while others may benefit psychological wellbeing. For example, boys who played video games regularly at age 11 had lower depression scores at age 14.

Depressed children and teenagers have an increased risk of suffering from premature death and a wide range of illnesses later in life. That is according to a large observational study by researchers at Karolinska Institutet in Sweden. The findings highlight the need to look for other potential diseases following childhood or adolescent depression. Other psychiatric conditions, such as anxiety and substance misuse, can explain part of the association. The study is published in JAMA Psychiatry.

It is a known fact that sexual minorities are at a higher risk of developing poor mental health, when compared to heterosexuals. The stigma that sexual minorities face has been regarded as potentially the primary cause of this. A new thesis from Karolinska Institutet offers an insight into how stigma-related factors may work in a broader socio-ecological system, considering the complex interaction between structural, interpersonal and individual factors.

Worry about COVID-19 dominates some people’s lives in a way that has an impact on their health. A group of researchers at Karolinska Institutet in Sweden has developed a digital CBT programme that significantly reduced the participants’ unhelpful worry about the pandemic. The study is published in Psychotherapy and Psychosomatics and the programme is available through 1177 Vårdguiden.

Girls who have been sexually abused run a much higher risk of psychiatric ill health with depression and anxiety, leading to possible alcohol abuse and suicide. This persists even after intervention, reports a study from Karolinska Institutet published in European Child & Adolescent Psychiatry.

“An important finding of the study was that any type of parental mental illness strongly increased the risk of childhood socioeconomic adversity.” says Kyriaki Kosidou, researcher at KI and corresponding author of the newly published article about parental mental illness and its association with socioeconomic adversity among children in Sweden.

Researchers at Karolinska Institutet have identified a protein in the brain that is important both for the function of the mood-regulating substance serotonin and for the release of stress hormones, at least in mice. The findings, which are published in the journal Molecular Psychiatry, may have implications for the development of new drugs for depression and anxiety.

The anaesthetic drug ketamine has been shown, in low doses, to have a rapid effect on difficult-to-treat depression. Researchers at Karolinska Institutet now report that they have identified a key target for the drug: specific serotonin receptors in the brain. Their findings, which are published in Translational Psychiatry, give hope of new, effective antidepressants.

Researchers at Karolinska Institutet show that different measures of psychopathology can be combined into a single factor, “p”, which predicts the patient’s prognosis and need of extra support. The general factor of psychopathology reflects the overall risk of adverse psychiatric outcomes with an accuracy equal to that currently used for intelligence, they report in a paper published in World Psychiatry.

The outbreak of the new corona virus is the cause of much anxiety, an anxiety that can lead to insomnia. Yet sleep is essential to our mental and physical health. Two psychologists at Karolinska Institutet have now collected some evidence-based tips for getting a good night’s sleep in the pandemic era.

Children of parents suffering from mental illness have a higher risk of injuries than other children, according to a study by researchers at Karolinska Institutet in Sweden, published in the journal BMJ. The risk is elevated up to 17 years of age and peaks during the first year of life. The findings highlight the need for parents with mental illness to receive extra support around child injury prevention measures as well as early treatment of mental morbidity among expecting parents.

Stress-related conditions such as adjustment disorder and clinical burnout can be effectively treated with a 12-week cognitive behavioural programme, both when delivered as a face-to-face treatment and when delivered via the internet, according to a new doctoral thesis from Karolinska Institutet.

Cognitive Behavioural Therapy (CBT) for patients with social anxiety not only helps to reduce anxiety levels but also seems to protect against accelerated cellular ageing, a study involving researchers at Karolinska Institutet published in the journal Translational Psychiatry reports.

Those with a family history of schizophrenia and men with lower IQ are more likely to struggle with treatment resistant schizophrenia than others with the mental disorder, according to a study by researchers at Karolinska Institutet in Sweden published in the journal Molecular Psychiatry. The researchers say the findings could be important in efforts to design novel drug treatments that improve cognition.

The risk of suicide attempts and suicides among individuals with autism spectrum disorders is significantly higher than among the population in general. An especially high risk of suicidal behaviour is noted among women who in addition to autism also have ADHD. These are the findings of a population-based study from Karolinska Institutet in Sweden published in the journal Psychological Medicine.

Christina Dalman and Kyriaki Kosidou, research group Epidemiology of Psychiatric Conditions, Substance use and Social Environment (EPiCSS), have together with researchers in Manchester estimated the prevalence of children and adolescents exposed to maternal mental illness in the UK between 2005 and 2017.

Hello, Galit Andersson, who recently defended a doctoral thesis at the Department of Public Health Sciences, Karolinska Institutet. For your thesis you conducted large surveys of transgender people and people living with HIV in Sweden to assay their quality of life.

The study, led by Professor Christina Dalman, will investigate early interventions in mental illness. Christina is group leader of the EPiCSS research group with the Department of Public Health Sciences.