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In the healthcare setting, keeping things clean can be vital to prevent the spread of dangerous bacteria. But in a household, what’s best for your health – to live pretty dirty or to be a clean freak? Read our interviews with the researchers who have a pure interest in cleaning.

Researchers at Karolinska Institutet and Danderyd Hospital have followed recipients of the new updated COVID-19 vaccine and analysed the antibody response to different SARS-CoV-2 variants. The results show a surprisingly strong response to the now dominant and highly mutated Omicron variants. [This news article has been updated]

Giulia Gaudenzi and Kelly Elimian are currently running a research project focused on assessing the diagnostic accuracy of rapid diagnostic test kits for detecting cholera in environmental water in comparison to standard diagnostic methods, such as culture and PCR, in Nigeria. They have conducted trainings in Nigeria on the use of these test kits.

The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis. Now, an article published in Science Immunology by researchers from Karolinska Institutet challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice.

Researchers at Karolinska Institute have developed a novel method using DNA Nanoballs to detect pathogens, aiming to simplify nucleic acid testing and revolutionize pathogen detection. The study's results, published in Science Advances, could pave the way for a straightforward electronic-based test capable of identifying various nucleic acids in diverse scenarios quickly and cheaply.

Her involvement in health crises work at KI goes back to her role in one of the expert groups that were formed at KI during the COVID-19 pandemic, which proceeded what became the Centre for Health Crises. Now she is the latest in the group of expert coordinators at the Centre. Hedvig Glans wants to use her clinical and academic experience to improve the Centre’s competence in outbreak preparedness and response to infectious diseases.

The current pandemic shows how quickly health misinformation can spread. However, there are tools to debunk misinformation as demonstrated by a new study on health communication strategies from Karolinska Institutet, published in the journal BMJ Global Health. The study, which focuses on misinformation about typhoid in Sierra Leone, also shows that explicitly addressing falsehoods seems more effective in busting misbeliefs than simply stating scientific facts.

The Erling Persson Family Foundation has awarded Johan Lundin a research grant of 10 million SEK divided over three years for the project Artificial intelligence for diagnostics of cancer and infectious diseases in resource-limited settings - the MoMic Project. Johan has just returned from Kenya, where he has been planning the next steps of the project.

Young people are at risk of falling seriously unwell with tuberculosis and spreading the disease. Therefore, researchers at Karolinska Institutet, among others, have mapped key factors that affect the treatment outcomes in 10- to 24-year-olds with tuberculosis in Brazil, where the disease is increasing. To deal with the global tuberculosis epidemic, researchers say that greater focus is needed on this age group in tuberculosis programs. The study is published in The Lancet Global Health.

Studying the implementation of public health interventions typically involves the identification of “facilitators” and “barriers”. In the case of active tuberculosis case-finding (also referred to as community-based tuberculosis screening), many studies have documented facilitators and barriers, but only few have explored the “how-to” of capitalizing on facilitators and overcoming barriers to put active case-finding into practice. This new study contributes to filling this gap.

An exciting new way has been found in which the body senses a bacterial infection within 4 hours and uses nerve pathways to trigger an immune response in distant organs. The speed by which an infection can be identified, and how the defence mechanisms are triggered is critical to infection outcome.

Nine out of ten cases of tuberculosis appear in 30 identified low and middle-income countries, each of which has a national tuberculosis programme. The managers of these programmes agree that it is important to screen for tuberculosis outside of health facilities. However, each screening programme must have its own well-considered, sustainable strategy and sufficient resources for it to be meaningful – which is not always the case today. This is one conclusion drawn by Olivia Biermann’s thesis.

Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection (STI), with about 127 million new cases estimated annually worldwide. Since it is an asymptomatic infection, individuals may carry it for a long time and unknowingly transmit the infection to others.

A literature review coordinated by Karolinska Institutet in Sweden and McMaster University in Canada demonstrates that cloth face masks provide clinically useful levels of filtration, which has the potential to reduce the spread of viruses such as SARS-CoV-2. The findings, now published in the journal Mayo Clinic Proceedings, support the wearing of cloth masks to reduce the spread of the new coronavirus, according to the researchers.

During the new coronavirus outbreak many researchers at Karolinska Institutet are contributing their competence and views to the public flow of information. Sharing knowledge is important. But researchers, particularly, must also base their reasoning on facts and express themselves clearly, including about matters of uncertainty, says Jan Albert, professor of infectious disease control at Karolinska Institutet and convenor of KI’s COVID-19 expert team.

Researchers at Karolinska Institutet in Sweden and the University of Basel in Switzerland have produced a mathematical model that shows that the spread of the new coronavirus can decline in the summer and then return in the autumn and winter. The analysis has been published in the scientific journal Swiss Medical Weekly.

The new corona virus continues to spread despite significant measures taken by the authorities in China to stop the outbreak. However, this time the fast response coupled with increased knowledge about the nature of the virus means the world is better placed to handle the outbreak compared to 18 years ago when SARS caused widespread concern, says virus researcher Ali Mirazimi, adjunct professor at the Department of Laboratory Medicine at Karolinska Institutet.

People who inject drugs and who are female, homeless or amphetamine users often share needles and syringes, and consequently run a higher risk of infection hepatitis C virus infection that affect the liver. However, as a new doctoral thesis from Karolinska Institutet demonstrates, early contact with a needle-exchange programme can have a protective effect.

The Jan Albert Group's research collaborator is featured in a podcast interview in The Lancet.

Hello there Knut Lönnroth, professor at the Department of Public Health Sciences and director of KI’s new TB research centre ... why has KI set up a TB centre?

An international team of researchers, led from Karolinska Institutet, has identified two receptors on the cells in the blood vessels of the brain that can be blocked and thereby prevent pneumococci from entering the brain. The study, which is published in The Journal of Experimental Medicine, shows that the use of antibodies that block the receptors can potentially be used as a new therapeutic strategy for pneumococcal meningitis.

Public authorities and organisations in Sweden are mobilising their resources in an effort to halt the Ebola epidemic in West Africa. Karolinska Institutet arranged a meeting to discuss existing challenges in terms of organising aid initiatives and there is a course starting on Monday that will prepare medical staff for their work in the countries most severely hit by Ebola.