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Key factors for health systems to maintain health services when faced with challenges are collaboration, clear decision-making for health system workers as well as flexible response plans, according to a new doctoral thesis from Karolinska Institutet.
One in three women in Europe inherited the receptor for progesterone from Neandertals – a gene variant associated with increased fertility, fewer bleedings during early pregnancy and fewer miscarriages. This is according to a study published in Molecular Biology and Evolution by researchers at the Max Planck Institute for Evolutionary Anthropology in Germany and Karolinska Institutet in Sweden.
Hello Ingmar Ernberg, co-editor and professor at the Department of Microbiology, Tumor- and Cell Biology (MTC). Congratulations to your new book “Kvantfysiken och livet” that has just been released. What is it all about?
The fragmented Swedish healthcare system with its various levels of care, principals and care providers can lead to negative consequences in a person’s care and rehabilitation. This is especially relevant when several providers are involved in a care trajectory, such as in people with stroke.
Jakob Skov from the group Experimental and Clinical Neuroendocrinology, Department of Molecular Medicine and Surgery, will defend his thesis "Epidemiological studies on comorbidity, heritability and co-aggregation in organ-specific autoimmune diseases" on June 5, 2020. Main Supervisor is Sophie Bensing.
Researchers at Karolinska Institutet have developed a new sequencing method that makes it possible to map how DNA is spatially organised in the cell nucleus – revealing which genomic regions are at higher risk of mutation and DNA damage. The technique is described in an article published in the scientific journal Nature Biotechnology.
Victor Bloniecki Kallio, PhD-student at the Division of Clinical Geriatrics. On May 27, 2020, you will defend your thesis "Using CSF biomarkers to understand mechanisms of behavioral changes and effects of drug treatment in dementia", what's the main focus of the thesis?
A simple blood test may help predict which people with multiple sclerosis (MS) will get worse during the following year, according to a study by researchers at Karolinska Institutet in Sweden published online in Neurology, the medical journal of the American Academy of Neurology.
It is highly likely that children can transmit the new coronavirus, which causes COVID-19, but several factors suggest that children are unlikely to be the main drivers of the pandemic. Opening up schools and kindergartens is unlikely to impact COVID-19 mortality rates in older people, according to a systematic review that spanned 47 publications and was conducted by researchers at Karolinska Institutet. The paper is published in the scientific journal Acta Paediatrica.
Childhood environment and socioeconomic status affect cognitive ability and brain development during adolescence independently of genetic factors, researchers at Karolinska Institutet report in a new study published in the journal PNAS. The study demonstrates how important the family environment is, not just during early infancy but also throughout adolescence.
Many severe symptoms in Parkinson’s disease are caused by the degeneration of the brain’s dopamine neurons. Transplantation of stem cell-derived dopamine neurons to patients with Parkinson’s disease is a therapeutic approach that is getting close to clinical application.
Tips from Grants Office about current calls
Tips from Grants Office about current calls
Dr. Sarah Bergen, a Senior Researcher at the Department of Medical Epidemiology & Biostatistics (MEB) at Karolinska Institutet, has been awarded a grant of approximately 1.2 million US dollars, from the National Institutes of Health (NIH), USA.
Our office hours week 21 are:

Monday: 8-17
Tuesday: 8-17
Wednesday: 8-17
Thursday: Closed
Friday: Closed
The implementation of Karolinska Institutet's new administrative system for core facilities, called iLab, has now begun. During the first week in June, the first six core facilities will receive access to the system and three more facilities will follow the last week of June. In all, the project delivery concerns 45 core facilities at KI.
Researchers at Karolinska Institutet are coordinating a recently initiated multi-national clinical trial that will evaluate the effect of hyperbaric oxygen treatment (HBO) in severe cases of COVID-19. A total of 200 adults admitted to hospital with moderately severe COVID-19 pneumonia will be recruited. The trial could start as early as next week at a hospital in Region Blekinge, Sweden.
KI Holding and its subsidiary KI Innovations have now combed forces by creating a common board, to which they have added three new members and a new chairperson.
Gonçalo Castelo-Branco at the Department of Medical Biochemistry and Biophysics (MBB) at Karolinska Institutet, receives the 2020 Eric K. Fernström prize for young, especially promising and successful researchers, for his significant research in the oligodendrocyte/myelin field and multiple sclerosis.
In order for students to continue their education, Karolinska Institutet (KI) has decided to make it possible to, during the summer, provide courses and activities that due to the prevailing pandemic could not be completed during the spring term.
EU-financed Innovative Medicines Initiative (IMI) has boosted funding for research on diagnostics, medicines and vaccines against the new coronavirus SARS-CoV-2. Ali Mirazimi, researcher at Karolinska Institutet and Sweden’s National Veterinary Institute (SVA), coordinates one of eight projects provisionally selected among 144 applicants.
The President has now decided on new guidelines for the assessment of suspected deviations from good research practice. A council has also been appointed at KI for investigating such deviations.
Christine Delisle Nyström and Peter Swoboda were selected for this year's Ax:son Johnson foundation grant. Christine for her research about obesity prevention in children and Peter for his new way to study eating disorders, especially 'Binge Eating'.
Researchers at Karolinska Institutet have compared two ways of delivering cognitive behavioral therapy to treat people with health anxiety, a condition that may increase in the wake of COVID-19. Out of about 200 study participants, half received Internet-CBT and half received conventional face-to-face CBT. The results, published in JAMA Psychiatry, show that Internet-delivered treatment had comparable effects, and may serve as an alternative in helping people who are worried about their health.
In a study recently published in Nature Methods, researchers from Karolinska Institutet and Oxford University have developed a method to identify molecules that are attached to proteins in the membrane.
Before the onset of the pandemic, staff at the Department of Global Public Health formed a climate and SDG-working group to raise awareness within our department of the on-going climate emergency. The climate group at GPH wants to raise awareness of the central impact of the climate emergency on global public health.
The focus of Johanna Sieurin's thesis was to investigate the relationship of personality and stress with subsequent risk of Parkinson’s disease (PD).
In a new study, researchers from the University of Copenhagen and Karolinska Institutet have found neurons in the brain that control how mice turn left and right. The studdy was recently published in the journal Nature Neuroscience.
Researchers at Karolinska Institutet show that different measures of psychopathology can be combined into a single factor, “p”, which predicts the patient’s prognosis and need of extra support. The general factor of psychopathology reflects the overall risk of adverse psychiatric outcomes with an accuracy equal to that currently used for intelligence, they report in a paper published in World Psychiatry.
The Strategic Research Area in Health Care Science (SFO-V) announce call for funding in health care science 2020-2021.
Maria Hagströmer has been appointed Professor of Physiotherapy at the Division of Physiotherapy. She has also been ben named deputy head of division with a special assignment as research coordinator, starting April 15.
KI Researchers present new insights on the ability of humans and other mammals to adapt to food availability and exposure to cold temperatures in a study recently published in eLife. The findings could enhance the development of new methods to treat metabolic disorders such as obesity or type 2 diabetes.
Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report how the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal Alzheimer’s & Dementia.
In severe cases of COVID-19, a massive release of the endogenous protein HMGB1 in the lungs may contribute to pulmonary inflammation and tissue damage, according to a recent review article published in the journal Molecular Medicine. The researchers conclude that the inflammation could hypothetically be treated with an HMGB1 inhibitor.
Three questions to Mats Hallgren, assistant professor at the Department of Global Public Health, first author of several publications studying the effects of sedentary behaviour on mental health. Two related studies show that the context of these behaviours appears to be relevant.

Patients with acutely decompensated cirrhosis frequently develop acute-on-chronic liver failure (ACLF), a syndrome characterized by intense systemic inflammation, multi-organ failure and high short-term mortality. The Craig Wheelock group has now contributed to a study, recently published in the Journal of Hepatology, that associates specific profiles of circulating lipid mediators with the severity and prognosis of patients with acutely decompensated cirrhosis.
The KI INMC steering group is pleased to announce the availability of limited competitive funds for grant applications by faculty, staff and/or trainees to conduct collaborative interactions within the International Network Medicine. The funds are to be used as “seed grants” aiming at starting and sustain collaborations within the field of network medicine.
Single-cell RNA sequencing (scRNA-seq) has revolutionized the ability to characterize cell types and their gene expression programs in organisms and tissues. Although great improvements in cellular throughput have been made, methods generally suffer from low sensitivity and quantification that is limited to short RNA pieces. Now, researchers at Karolinska Institutet have released Smart-seq3 that greatly improves the quality in scRNA-seq. The study is published in Nature Biotechnology.
According to many observations, certain virus infections may play a part in the autoimmune attack that leads to type 1 diabetes. Researchers at Karolinska Institutet in Sweden and their Finnish colleagues have now produced a vaccine for these viruses in the hope that it could provide protection against the disease. The study is published today in the scientific journal Science Advances.
Many nerve cells in the brain region hypothalamus have unexpected origins and go through complex development programs, where millions of neurons assemble into a precisely knit network by birth. That is according to a study by researchers at Karolinska Institutet in Sweden and the Medical University of Vienna published in the journal Nature. The findings may further our understanding of hormonal diseases and their origins, according to the researchers.
Conducting examinations at a distance puts different demands on you as a teacher. There are several possible solutions available for conducting oral and written examinations digitally. Information on how to proceed, guidelines and support if you need is now available.
Tips from KI Grants Office about current calls
There are currently two calls on sharing your experiences at Karolinska Institutet. One with the possibility to share your story during the ongoing pandemic. And one call with the possibility to contribute to the pandemic memory bank for the future historiography.
The current pandemic affects all aspects of Karolinska Institutet and Karolinska University Hospital, and one day, researchers, archivists and others will want to learn about how Swedish healthcare and Swedish research responded to it. The Medical History and Heritage Unit is gathering source material and needs your help to preserve the moment!
João Ramos from the group Clinical Physiology at the Department of Molecular Medicine and Surgery will defend his thesis "Pulmonary hypertension and heart failure : physiological markers assessed by cardiovascular magnetic resonance" on May 8th, 2020. Main Supervisor is Martin Ugander.
KW
KI webbteam
2020-06-08