News archive

Breast cancer tumours can contain different cell types and structures, which may influence how the disease develops and responds to treatment. In a new thesis from Karolinska Institutet, Qiao Yang at the department of oncology pathology uses computer based methods and multi omics data to map this variation in large, untreated breast tumours. The findings may help support more comprehensive diagnostic strategies and inform future treatment decisions.

Cancer is complex and hard to treat, with many forms that change over time. This makes treatment complicated: a drug may help one patient but not another. Developing new cancer drugs is also slow and costly, often taking years and failing before reaching patients. This thesis explores how advanced laboratory models and artificial intelligence could make the process faster.

A new study in Nature Communications reveals how immune cells rapidly shut down their response after activation, preventing damage to healthy tissue. Researchers from Karolinska Institutet, sheds light on a molecular ‘kill switch’ that could help control infections or autoimmune diseases.

Long-term use of medications for heartburn and acid reflux, known as proton pump inhibitors, does not appear to increase the risk of stomach cancer, according to a new study published in The BMJ. The results are based on extensive Nordic health data and may provide reassurance to patients who need long-term treatment, according to researchers at Karolinska Institutet.

A simple blood test can help detect cancer in patients with non-specific symptoms such as fatigue, pain or weight loss. This is according to a Swedish study from Karolinska Institutet, Danderyd Hospital and others, published in Nature Communications.

Girls who are vaccinated against HPV are not only well protected against cervical cancer; they are also less likely to develop severe precancerous lesions of the vulva and vagina, particularly if they were vaccinated before the age of 17. This is shown in a new study from Karolinska Institutet published in JAMA Oncology.

Researchers at Karolinska Institutet have identified small molecules capable of influencing a hard-to-target receptor family linked to cancer development. The findings have been published in Nature Communications and the Journal of Biological Chemistry.

At the beginning of 2026, Karolinska Institutet announces research grants from the Hildegun and Mats Guldbrand research foundation for research in immune regulation and women's diseases.

The 2026 funds for the category of women's diseases refer to research in gynecological cancer.

A new international study published in The Lancet Oncology shows that artificial intelligence (AI) can be more accurate than experienced radiologists in detecting pancreatic cancer on computed tomography (CT) scans. The study is a collaboration between Radboud University Medical Center in the Netherlands, Karolinska Institutet in Sweden, and the University of Bergen in Norway.

The Karolinska Institutet (KI) and Shandong University (SDU) held their Joint Symposium in Jinan, China, on November 17–18, 2025, on the theme of cross-disciplinary medical research.

The Karolinska Institutet (KI) and the Chinese Academy of Medical Sciences (CAMS) hosted their annual joint symposium in Stockholm on October 21–22, 2025, bringing together leading experts to strengthen high-level research collaboration.

One of the promising young researchers receiving Knut and Alice Wallenberg Foundation’s basic research grant this year is Camilla Engblom at the Department of Medicine, Solna. She will use the funding to study a piece of the puzzle that could help develop more precise and personalized treatments for cancer and inflammatory bowel disease.

Artificial Intelligence that detects breast cancer, enables medical imaging in low-resource countries and that identifies the patients who require advanced treatment even at the point of diagnosis – these are just a few examples of AI research at Karolinska Institutet that is impacting an entire world. Parts of this work were presented during the conference AI@KI, Advances in Artificial Intelligence at Karolinska Institutet, on 2 December.

Sara Mijwel Cardinale and Maria Hagströmer are the recipients of the grants.

The Swedish Cancer Society (Cancerfonden) has announced its research grants for 2025. Around 73 million has been awarded to researchers at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet.

A puzzling experiment in the 1970s led to the discovery of a new type of immune cell. In 2025, the NK cells celebrate their 50th anniversary. Rolf Kiessling tells the story of the serendipitous finding that changed the course of his career.

In the Swedish Cancer Society’s latest call, research grants totalling SEK 34 300 000 were awarded to 11 researchers at the Department of Medicine, Huddinge (MedH) for the years 2026–2028.

Researchers at Karolinska Institutet have discovered how cells can adjust their gene activity to survive when oxygen runs low. The study, published in Nature Cell Biology, reveals that cells use a previously unknown mechanism to control which proteins are produced – and how quickly.

A new study from Karolinska Institutet, published in npj Precision Oncology, shows that support cells in the adrenal gland can regenerate hormone-producing tissue after birth. The same cells may also act as a starting point for adrenal tumors, offering new insights into cancer development and potential treatment strategies.

Researchers from Karolinska Institutet and Albert Einstein College of Medicine have shown that glioblastoma, the most aggressive form of brain cancer, not only affects the brain but also erodes the skull and alters the immune system in the bone marrow. The findings are published in Nature Neuroscience.

Welcome to the annual KI-CAMS joint symposia on Respiratory Medicine, Cardiovascular Research and Population Medicine.

Hi Melissa Kotte, doctoral student at the Division of Nursing. On October 24, you will defend your thesis ”Reaching cancer survivors where they are : effects and experiences of live-remote exercise”. What is the main focus of the thesis?

Businessman Fredrik Lundberg is donating SEK 30 million to Karolinska Institutet and a research project looking into how the immune system can combat colorectal cancer and prevent it spreading.

Pancreatic cancer is one of the most aggressive cancer types. A new study from Karolinska Institutet, in collaboration with the Department of Pathology at Karolinska University Hospital, shows that tumour cells grow not only in the connective tissue–rich environment typical of the disease, but also in damaged parts of the pancreas where normal tissue is altered. The findings may provide new insights into tumour development and treatment.

A study led by Vincenzo Condello and Christofer Juhlin, has been published in Endocrine Pathology. The researchers explored why some papillary thyroid cancers don’t respond well to radioactive iodine (RAI) therapy - a key treatment used after surgery to eliminate remaining thyroid cancer cells.

The greatest challenge facing current treatments of leukaemia is drug resistance. Hong Qian studies the microenvironment where the cancer cells are formed with the aim to find new treatment pathways. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 9 October.

A Swedish-led research team at Karolinska Institutet and Karolinska University Hospital has shown in a new randomized clinical trial that a low dose of the well-known medicine aspirin halves the risk of recurrence after surgery in patients with colon and rectal cancer with a certain type of genetic alteration in the tumor.

It is the spread of tumours, metastases, which is the usual cause of cancer-related death. Jonas Fuxe researchers the mechanisms driving this process, with a focus on how cancer cells interact with their surroundings and mutate in order to take new paths. Meet one of the new professors of Karolinska Institutet who will participate in this year's installation ceremony at Aula Medica on 9 October.

According to a study by Karolinska Institutet, nearly three times as many people under the age of 50 in Sweden are diagnosed with colorectal cancer today compared with the early 1990s. The study also shows that mortality is elevated in both younger and older patients for up to ten years after diagnosis.

A new study by researchers at Karolinska Institutet and Karolinska University Hospital shows that patients diagnosed with the rare skin cancers mycosis fungoides and Sézary syndrome face a significantly higher risk of dying from lymphoma and infections compared to the general population. The study was recently published in the British Journal of Dermatology.

People who have survived cancer as children are at higher risk of developing severe COVID-19, even decades after their diagnosis. This is shown by a new study from Karolinska Institutet published in the journal The Lancet Regional Health – Europe.

Pathologists' examinations of tissue samples from skin cancer tumours improved when they were assisted by an AI tool. The assessments became more consistent and patients' prognoses were described more accurately. This is shown by a study led by Karolinska Institutet, conducted in collaboration with researchers from Yale University.

Karolinska University Hospital has, for the first time in Sweden, begun preparations to treat a patient with multiple myeloma using CAR-T cell therapy in routine healthcare – an advanced form of immunotherapy where the patient's own T-cells are programmed to attack cancer cells. The treatment is aimed at patients who no longer respond to previous treatment options and offers new hope for a difficult-to-treat blood cancer.

Håkan Mellstedt, Professor at the Department of Oncology-Pathology, Karolinska Institutet, has passed away at the age of 82.
He is mourned by his wife Eva and Håkan’s brother with family. He leaves behind a long and exceptionally successful legacy as a colleague, researcher, and friend.

Researchers at Karolinska Institutet and Lund University have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer. By combining two antioxidant enzyme inhibitors, they have converted cancer cells in mice into healthy nerve cells. The study is published in the journal Proceedings of the National Academy of Sciences (PNAS).

A new Swedish registry study shows that women who are affected by cervical cancer are not only at risk of mental health and financial difficulties themselves – their children and partners also appear to be negatively affected. The study is published in the prestigious scientific Journal of the National Cancer Institute.

The prestigious Nordic Anders Jahre Award for 2025 goes this year to two researchers at Karolinska Institutet. Professor Sten Eirik Wælgaard Jacobsen is to receive the Anders Jahre Award for Medical Research for his work on normal and leukemic blood stem cells. William Nyberg is honoured with the Anders Jahre Award for Young Researchers for his work on the development of T-cell immunotherapy for cancer.

Karolinska Comprehensive Cancer Center (Karolinska CCC) will be the first center in Sweden to receive renewed accreditation. This milestone marks an important step in further strengthening the collaboration between Karolinska University Hospital and KI. Childhood cancer is now also part of Karolinska CCC.

The partnership between Johnson & Johnson Innovative Medicine (J&J) and Karolinska Institutet (KI) marks this year a decade of joint initiatives for promoting the development of tomorrow’s therapies. This long-standing collaboration between industry and academy has given rise to significant scientific advances in several fields of medicine.

Swedish cancer patients treated with CAR T-cell therapy show better survival rates and fewer side effects than seen in previous studies. This is shown in a new compilation of Swedish treatment results conducted by researchers in the SWECARNET network.

A newly published study involving researchers from Karolinska Institutet indicates that prostate cancer can be diagnosed at an early stage through a simple urine sample. With the aid of AI and extensive analyses of gene activity in tumours, they have identified new biomarkers of high diagnostic precision.

Researchers at Karolinska Institutet have uncovered a unique ability of a special subtype of natural killer cells in the immune system, called adaptive NK cells, to remember ovarian tumours and effectively attack them. The discovery, published in Cancer Immunology Research, could pave the way for new, more powerful immunotherapies for difficult-to-treat cancers.

The 5th edition of the World Health Organization (WHO) Classification of Endocrine and Neuroendocrine Tumors has now been officially published in print. This highly anticipated reference work is widely regarded as the global gold standard for tumor diagnosis, offering a comprehensive synthesis of traditional histopathology with cutting-edge digital and molecular pathology.

In a new study, researchers from Karolinska Institutet have shown that so-called interval cancers, which are detected between two screening sessions, account for a significant proportion of breast cancer cases and that certain risk factors may increase the likelihood of developing this type of cancer. The study was published in the journal JAMA Oncology.

In a study published in Nature, researchers at Karolinska Institutet and SciLifeLab, among others, have identified a new mechanism for how cells deal with stress. This could have implications for treating certain hereditary, neurodegenerative diseases, but may also be relevant for future cancer treatment.

Helene Lindfors, PhD student at the Endocrine Surgery research group, the Department of Molecular Medicine and Surgery, will defend her thesis "Tumor burden, thyroglobulin and Ki-67 as prognostic indicators in papillary thyroid cancer" on April 2025.
Main supervisor is Ivan Shabo.

In a study on ovarian cancer cells, researchers from Karolinska Institutet demonstrate how the tumor environment influences how cancer cells respond to drugs by using AI. The study has been published in the journal Communications Biology.

Professor Rolf Kiessling at Karolinska Institutet has been selected as the recipient of the 2025 CIMT Lifetime Achievement Award for his groundbreaking discovery of natural killer (NK) cells, which has significantly advanced our understanding of the immune response to viruses and cancer cells.

Researchers at Karolinska Institutet and Karolinska University Hospital have identified biomarkers in the blood that can be used to distinguish gallbladder cancer from inflammation of the gallbladder. This could lead to fewer unnecessary operations and better treatment decisions for patients with suspected gallbladder cancer. The study has been published in the journal JHEP Reports.

Researchers from Karolinska Institutet have developed a new way to understand how cancer drugs interact with different forms of protein. The study has been published in Nature Communications.