News archive

The Stockholm3 blood test, developed by researchers at Karolinska Institutet, is equally effective at detecting prostate cancer in different ethnic groups, a new paper published in The Journal of Clinical Oncology reports. The test produces significantly better results than the current PSA standard.

Researchers at the Center for Infectious Medicine at the Department of Medicine, Huddinge have developed a new strategy that can make cell therapy against cancer work longer in patients. The results are published in the journal Cell Stem Cell.

Researchers at Karolinska Institutet have developed nanorobots that kill cancer cells in mice. The robot’s weapon is hidden in a nanostructure and is exposed only in the tumour microenvironment, sparing healthy cells. The study is published in the journal Nature Nanotechnology.

A new study from Karolinska Institutet shows that 45 genes may play a crucial role in the prognosis of patients with adrenal cancer. The findings, published in the journal ESMO Open, give hope for a better diagnostic tool than is currently available.

Welcome to a SDU - KI joint symposia on structural biology and cancer research
Monday 17 June at 10.15 - 17.00 at BioClinicum J3:14, Kerstin Hagenfelt Auditorium
No registration needed. Coffe/tea and lunch is served.

On June 3rd, the Theranostics Trial Center (TTC) was inaugurated as a new section within the Department of Nuclear Medicine and Hospital Physics, Medical Diagnostics Karolinska (MDK) with an academic base within the Department of Oncology-Pathology at Karolinska Institutet.

Researchers at Karolinska Institutet and the University of Innsbruck have developed a simpler and more effective screening method for cervical cancer than the method used today. A comprehensive study published in Nature Medicine shows that the test detects significantly more cancers and precancerous stages.

Researchers from the Clinical Genetics Group at the Department of Molecular Medicine and Surgery, Karolinska Institutet, have set up a collaboration with the Centre for Research and Technology in Greece to make publicly available resources in biology and cancer more accessible to the research community. The teams are developing a first-of-its-kind cancer knowledge graph, as part of the SciLake Project involving partners across Europe.

Together with researchers from University of Oxford, researchers at Karolinska Institutet have demonstrated that a subclass of stem cells that are dedicated to the production of platelets replenish platelets through a distinct and shorter pathway than other stem cells. This is presented in a study published in the journal Nature Immunology.

Society's preparedness to deal with crises and disasters needs to be constantly developed and adapted to changes in the world around us. As preparedness depends on up-to-date medical expertise, the Swedish National Board of Health and Welfare has established a number of knowledge and research centres for crisis preparedness around the country, located at universities, authorities or equivalent with links to clinical activities.

Karolinska Institutet and Karolinska University Hospital are launching another tripartite collaboration, this time with Elekta. The aim is to join forces in the field of cancer with a focus on radiation therapy and precision medicine.

Researchers at Karolinska Institutet have succeeded in delivering targeted cancer treatment via small membrane bubbles that our cells use to communicate. A new study published in Nature Biomedical Engineering shows that the treatment reduces tumour growth and improves survival in mice.

In an article published in Nature, researchers from Karolinska Institutet present an atlas of the early development of the brain. The atlas can be used, among other things, to find out what went wrong in the development of brain tumors in children and also to find new treatments.

Karolinska Institutet (KI) and Charité - Universitätsmedizin Berlin (Charité) have entered into a bilateral agreement. The Internationalisation Board at KI is pleased to announce the availability of limited competitive funds for KI faculty and staff for grant applications to strengthen collaborative interactions within research and education.

The 2024 Karolinska Comprehensive Cancer Centre Day draw a large number of experts in the field of cancer research from KI and Karolinska University Hospital. The theme this year was prevention, with particular attention directed to scientific advances and remaining challenges, as well as to how involving patients in prevention enhances quality of care.

Angelique has a background in KI, where she obtained her medical degree, her path has been paved through many years of clinical service at Karolinska University Hospital and she is a specialist in both gynecology & obstetrics and gyneoncology.

For 2 years the Translational Seed Funding Grant 2023 will support the collaborative project between the Schulte lab at Fyfa and the research team of Prof Matthias Löhr at CLINTEC.

Drugs known as GLP-1 analogues have become increasingly popular to treat diabetes and obesity, but there have been concerns that they might increase the risk of thyroid cancer. Now an extensive Scandinavian study led by researchers at Karolinska Institutet has found no evidence of such a link. The study is published in The BMJ.

The Swedish Childhood Cancer Fund (Barncancerfonden) has decided to grant funding to eight research positions at KI for paediatric oncology research over the next two to six years. The goal is, among other things, to improve current treatment methods with the help of precision medicine that is based on the characteristics of the cancer and the individual child's genetics.

It is possible to leave most of the lymph nodes in the armpit, even if one or two of them have metastases larger than two millimetres. This is shown in a trial enrolling women from five countries, led by researchers at Karolinska Institutet and published in the New England Journal of Medicine. The results open up for gentler surgery for patients with breast cancer.

In a new study published in Molecular Oncology, researchers have discovered a novel mechanism to enhance the body’s immune response to tumors. The study is a result of collaboration between Sprint Bioscience, Karolinska institutet, the Luxembourg Institute of Health and Deciphera Pharmaceuticals, and was included as a manuscript in Yasmin Yu’s PhD thesis at the Department of Oncology-Pathology in 2021.

Catherine J. Wu, of the Dana-Farber Cancer Institute in Boston, USA, is a pioneer in research that may result in the development of personalised vaccines to treat cancer. She is now awarded the Sjöberg Prize, worth one million US dollars, for her work. Catherine J. Wu will give a lecture in Aula Medica at KI on April 12 in connection with the Karolinska CCC Day.

Ullakarin Nyberg is a researcher at the Center for Psychiatry Research at Karolinska Institutet. She also works clinically as a psychiatrist, part of the time at a unit for breast cancer patients. At the end of 2018, she contracted the disease herself.

Can breast cancer patients who exercise get better results from their chemotherapy? And if so, should they receive treatment that includes exercise? This will be investigated in an international study led by researcher Jana de Boniface.

It is difficult to draw firm conclusions about how to eat and drink to avoid breast cancer. Dietary studies often rely on self-reporting, while dietary habits change over the course of a lifetime - both of which are complicated for researchers. But one link is well documented: even moderate alcohol consumption increases the risk of developing the disease, says Professor Alicja Wolk.

There is a lot going on in breast cancer research. A new AI tool is trying to fine-tune the screening program, another is helping pathologists make diagnoses, and new drugs are being tested and approved. This could save more lives. But there is still no answer to the trickiest question of all: Why does breast cancer occur?

In a recently published review in the journal Biomarker Research, Joanna Zawacka, Docent at the department of Oncology-Pathology discusses our current understanding of p53 biology in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).

Sweden and the USA have previously enjoyed strong collaboration in the field of cancer care and research, and now it is further strengthened through a bilateral agreement. The purpose is to promote exchange between the two countries in both cancer research and the implementation of this research within cancer care, including both prevention and improved quality of life.

In recent years, the treatment landscape for solid tumors has undergone a notable change. With new cancer treatments, the future looks brighter for many young cancer patients, making fertility issues and future family planning an important aspect. Six specialists in oncology and onco-fertility at the Department of Oncology-Pathology join forces to compile knowledge and recommendations on this important issue.

KI researcher Laura Baranello has been awarded the prestigious ERC Consolidator Grant for her researches into the interaction between the cancer-driving protein MYC and topoisomerase enzymes. Her aim is to identify drugs for more targeted cancer therapy with fewer side-effects. Laura Baranello’s MYCinTOPshape project has been awarded approximately EUR 2 million to be spread over five years.

A large international research study, COSMOS, initiated by Karolinska Institutet and Imperial College London, UK, has studied over 250,000 mobile phone users to investigate whether those who use mobile phones a lot and for a long time have a higher risk of brain tumours than others. The study, published in Environment International, found no association between long-term cell phone use and the risk of brain tumors.

New research from Karolinska Institutet shows how oestrogen protects against MASLD, a fatty liver disease that has increased dramatically during the current obesity epidemic. The study, published in Molecular Systems Biology, shows how a new drug under development could become a future treatment for fatty liver disease and liver cancer.

Through a new call form, the Swedish Childhood Cancer Fund is funding two research programmes that will look at different types of unwanted side effects, primarily from chemotherapy. Precision medicine and the opportunities offered by the development of biomarkers are common to the two programmes, which are led by KI researchers Susanna Ranta and Kenny Rodriguez-Wallberg, respectively, and which now share SEK 19 million over four years.

In a study published in Nature Communications, KI researchers have revealed a fascinating discovery that could be important in cancer treatments. This new insight involves c-MYC, a protein component that is central to cancer development.

Recent and unintentional weight loss is associated with an increased risk of a cancer diagnosis in the coming year, according to a new study in JAMA. Researchers from Karolinska Institutet and others behind the study urge healthcare professionals and the public to be vigilant about sudden and unintentional weight loss.

Researchers at Karolinska Institutet and SciLifeLab demonstrate in a new study published in iScience how they can identify substances that can deactivate an enzyme responsible for chemotherapy resistance in cancer cells. These results can have importance to improve chemotherapy effectiveness for cancer patients.

The p53 tumor suppressor protein is encoded by TP53, the most frequently mutated gene in cancer. A review article published in Nature Reviews Clinical Oncology by professor Klas G Wiman and colleagues at the Department of Oncology-Pathology describes how p53 could be used as a target for new cancer therapies.

In clinical studies, new methods and treatments are tested on humans under controlled conditions. However, clinical treatment studies are often very expensive to carry out and require resources that allow many different professional groups to work together. The Swedish Cancer Society has now decided on an extra allocation of grants to ten researchers for clinical studies. Six of these are researchers at Karolinska Institutet.

The Swedish Childhood Cancer Fund's allocation reflects the needs that exist in areas such as new technology and precision medicines. This year's call for proposals means that SEK 125 million will be allocated to 62 projects in the field of childhood cancer, of which SEK 35,400,000 will go to researchers at Karolinska Institutet.

A new method, developed at Karolinska Institutet, KTH Royal Institute of Technology and SciLifeLab, can identify unique immune cell receptors and their location in tissue, a study published in the journal Science reports. The researchers predict that the method will improve the ability to identify which immune cells contribute to disease processes and open up opportunities to develop novel therapies for numerous diseases.

A new study from Karolinska Institutet has found no evidence that a common drug used to protect the ovaries of women undergoing chemotherapy increases their chances of having children after cancer treatment. The study is published in eClinicalMedicine.

The use of AI makes it possible for women with a high risk of breast cancer to be identified in mammography screening examinations so that the cancer can be caught earlier. An international research group led from Karolinska Institutet in Sweden can now show that the method is effective in different European countries. The study is published in The Lancet Regional Health – Europe.

We wish to congratulate the six researchers at the Department of Biosciences and Nutrition (BioNut) at Karolinska Institutet, who has received funding from Cancerfonden for the years 2024 to 2026. Together the researchers at our department received more than SEK 21 millions.

Researchers at Karolinska Institutet and SciLifeLab have combined artificial intelligence (AI) techniques used in satellite imaging and community ecology to interpret large amounts of data from tumour tissue. The method, presented in the journal Nature Communications, could contribute to more personalised treatment of cancer patients.

KI researcher Stefan Skare receives funding from Barncancerfonden (the Swedish Childhood Cancer Fund) for the development of motion-robust MRI (magnetic resonance imaging) methods for examining awake children with brain and spinal cord tumors. The project receives a total of SEK 3.9 million over three years.

More and more researchers understand the importance of including the patients' experiences when planning scientific studies. Meet three people who have been hired as experts in their own illness.

A new publication in Science Advances from researchers at Karolinska Institutet shows how to use a specific cancer trait to improve treatment of pancreatic tumors.

The Swedish Childhood Tumor Biobank is a nationally established genomic biobank infrastructure in the field of childhood cancer that works to promote research on childhood tumors. Within the Genomic Medicine Sweden (GMS) Child Cancer project, the Swedish Childhood Tumor Biobank at KI and the Department of Oncology-Pathology receive SEK 5.13 million from the government.

Researchers at Karolinska Institutet and the University of Oslo present a new type of immunotherapy that attacks cancer cells with a specific mutation. A study published in the journal Nature Cancer shows promising effects on patient cells in mice and offers hope for patients with acute myeloid leukaemia (AML), a cancer that has proven difficult to treat.

Reflux disease manifests as acid regurgitation and heartburn and is a known risk factor for oesophageal cancer. However, a new study published in The BMJ by researchers at Karolinska Institutet now reports that the majority of patients do not have a higher risk of cancer. A large-scale study from three Nordic countries shows that the cancer risk is only elevated in patients whom gastroscopy reveals to have changes in the oesophageal mucosa.