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A new study from Karolinska Institutet in collaboration with BUP Stockholm has conducted a pilot evaluation of a family-based cognitive behavioral therapy for adolescents with suicidal behavior. The study, published in the scientific journal BMJ Mental Health, shows that the treatment Safe Alternatives for Teens and Youths (SAFETY) may be a promising option for reducing suicide attempts.

The debate on nature versus nurture has never ceased, particularly in discussions about neurodevelopmental conditions (NDCs) such as autism and attention-deficit hyperactivity disorder (ADHD). These lifelong conditions emerge in childhood, and while they mostly have genetic nature, environmental factors may play a role.

A new study from Karolinska Institutet shows that severe mental illness is more common in patients with chronic kidney disease and negatively affects their health. The study has been published in the American Journal of Kidney Diseases.

New genetic risk factors for depression have been identified across all major global populations for the first time, allowing scientists to predict risk of depression regardless of ethnicity. The world’s largest and most diverse genetic study ever of major depression has revealed nearly 300 previously unknown genetic links to the condition.

We congratulate Johan Bjureberg on receiving almost SEK 20 million from VR Behandlingsforskning for the study Preventing Suicide With Safe Alternatives for Teens and Youths (SAFETY): A Randomized Clinical Trial of a Psychosocial Intervention.

Dr Isabell Brikell has been awarded the Kathy Sylva ‘Rising Star’ Award 2024 from ACAMH - The Association for Child and Adolescent Health.

Vaccination coverage for COVID-19 is high in both people with and without mental illness, according to a large multinational study led by researchers at Karolinska Institutet and published in Nature Communications. However, Swedish registry data revealed that individuals with unmedicated mental illness have lower vaccination levels.

Our understanding of autism has changed significantly in the past years. Previously viewed as a rare childhood disorder with a focus on deficits and pathology, autism is now recognized as a common, lifelong and heterogenous condition characterized by a broad spectrum of strengths and challenges. With increasing numbers of autistic adults and in particular females, a better understanding of autism in young adulthood for autistic females and males is warranted.

Girls with mental illness or neurodevelopmental conditions are less likely than their peers to be vaccinated with the HPV vaccine that protects against future cervical cancer. This is according to a new registry study from Karolinska Institutet published in The Lancet Public Health.

FitForLife is a study where patients with psychosis are educated to physical exercise trainers. For 6 months the trainers led exercise sessions for their fellow patients at sixteen psychiatric outpatient units in three regions. The most important finding was that 6 months after the study ended 15 out of the 16 units continued with the concept. The researchers have seen effects on need of care, social skills and metabolic markers.

A new study shows weak associations between psychiatric symptoms and selected inflammatory biomarkers in patients with chronic pain. The study found that sickness behavior contributed more to explaining psychiatric comorbidity.

How do carers reason when deciding to treat patients with borderline personality disorder (BPD) under compulsory care? Is compulsory care ethically defensible? A new thesis by psychiatrist Antoinette Lundahl tries to answer these questions and concludes that there is much to indicate that compulsory care does not help patients with BPD and can even increase the risk of suicide.

A comprehensive registry study from Karolinska Institutet shows that children of women who suffer from post-traumatic stress disorder (PTSD) right before or during pregnancy are almost twice as likely to be diagnosed with ADHD later in life. The study is published in the journal European Psychiatry.

A recent study by researchers from Karolinska Institutet and Uppsala University has found that cognitive impairment varies significantly among individuals with newly diagnosed psychosis.

Suicide is one of the leading causes of death in young persons in Sweden and globally. The last decades have seen an increasing proportion of the youth population engaging in university level education. The university period usually coincides with other important life events such as moving away from home. Early adulthood is furthermore a period when severe mental disorders, such as bipolar disorder and schizophrenia, may become symptomatic.

Chronic kidney disease (CKD) affects over 10% of adults worldwide. Mental health is an important yet under-recognized issue in patients with CKD. Depression is common and related to poor prognosis in CKD patients, but previous research has primarily focused on dialysis patients, leading to an insufficient understanding of depression in earlier stages of CKD.

Women who suffer depression during or after pregnancy have a higher risk of death by both natural and unnatural causes, a new study of childbirth in Sweden published in The BMJ reports. The increased risk peaks in the month after diagnosis but remains elevated for as long as 18 years afterwards.

The mhGAP guideline supports countries to strengthen capacity to deal with the growing burden of mental, neurological and substance use (MNS) conditions and narrow the treatment gap. These recommendations were first published in 2010 as part of the mhGAP intervention guide. The third edition of the mhGAP handbook, reflecting 15 years of investment, covers 11 modules on various mental health disorders and related conditions.

Major Depressive Disorder (MDD) is a common mental disorder, affecting around 20% of the population worldwide. Several causes that can lead to MDD, and patients display a wide range of symptoms as well as responses to treatments. This diversity makes it challenging to pinpoint the root causes, understand the underlying mechanisms, and tailor treatments effectively. Suicide is a pressing public health concern, impacting not only individuals living with MDD but also the general population.

Gambling addiction can increase the risk of long-term sick leave for several years, according to a new study published in Psychological Medicine. Researchers from Karolinska Institutet behind the study point to the need to detect people with gambling addiction in time to avoid financial and health problems.

More and more researchers understand the importance of including the patients' experiences when planning scientific studies. Meet three people who have been hired as experts in their own illness.

KI researcher Carl Sellgren has been awarded the Bjarne Ahlströms Minnesfonds pris 2023 (Bjarne Ahlström Memorial Fund Prize 2023) for his research in clinical neurology and how the loss of synapses (contacts between cells) in the brain could be a possible cause of schizophrenia.

Mania is a possible but rare side effect of treatment with antidepressant medication in adults, but little has previously been known of this risk in depressed children and adolescents. A newly published paper in JAMA Psychiatry investigated this, finding no evidence of mania/hypomania induced by antidepressants by 12 weeks after treatment initiation. However, caution is necessary in treatment for children with more severe depression or where a parent has bipolar disorder.

Sten Lundin set his apartment on fire and was convicted of arson. It turned out that he had bipolar disorder and the care he got helped him on feet again. "Life can sometimes turn around. I want everyone to know that", says Sten Lundin.

She was deprived of liberty for over ten years. "I feel a great deal of sadness that it took so long before I received proper care", says Jenny.

Who is at the highest risk of committing violent acts - and who is not? Forensic psychiatrist Jonas Forsman's researches involves an instrument that can, in a best case scenario, simplify the assessment of most forensic psychiatric patients.

Anette Johansson conducts research on what separates psychotic people who commit crimes from psychotic people who do not.

7.5 years That is the average treatment time for a person who has been sentenced to forensic psychiatric care. This is 2.5 years longer than what previous figures has lead us to believe.

In 2022, roughly 350 people were sentenced to forensic psychiatric care. There is a unique borderland between the judicial system and healthcare, in which a person who has completed their medical treatment can be prevented from being discharged. At the same time, many patients are saying that they have benefited from the care. And fewer people relapse into crime after they have received forensic psychiatric care than they do after being imprisoned.

It is quite common that individuals who have one psychiatric condition, also qualify for other psychiatric conditions. This observation questions the conventional belief that different diagnoses are independent, and instead implies the possibility of a set of factors that increases risks for several types of mental health problems.

New research from Karolinska Institutet published in JAMA Psychiatry shows how suicide attempts among people with depression is associated with higher mortality and impaired functionality.

Bipolar disorder underlies roughly five percent of all suicides among young people. Previous studies also show that there is often a long delay between the onset of bipolarism and its correct diagnosis and treatment. Researchers at Karolinska Institutet now show that fewer boys commit suicide in Swedish regions where bipolar diagnoses are more common. The study, which is published in JAMA Psychiatry, could contribute to more proactive care for reducing the number of suicides.

A Scandinavian collaboration led by KI researchers shows that of individuals treated in specialist care for major depressive disorder (MDD), many have a severe prognosis, for instance experiencing recurrence, developing other psychiatric disorders, requiring inpatient treatment, and some even dying by suicide. This research was based on 273,000 individuals with MDD in Sweden, Denmark, and Norway. The findings are published in Lancet Regional Health Europe.

Medical sleep treatment may reduce self-harm in young people with anxiety and depression, an observational study from Karolinska Institutet suggests. The risk of self-harm increased in the months preceding melatonin prescription and decreased thereafter, especially in girls. The study is published in The Journal of Child Psychology and Psychiatry.

Rumours spread faster than ever nowadays thanks to social media, and it is easy to get carried away. Some people are also inherently more vulnerable to conspiracy theories. However, sceptics’ concerns should be addressed, not dismissed, say researchers who are studying people’s willingness to take different kinds of vaccines.

A new study published in BMC Public Health, shows that screening in schools can improve psychotic symptoms in adolescents. The study is partly produced by researcher at the National centre for suicide research and prevention at Karolinska Institutet.

The interplay between sex steroid hormones, psychiatric- and neurodevelopmental disorders and adverse behavioral outcomes is in focus in a new thesis from Karolinska Institutet.

Hi Sandra af Winklerfelt Hammarberg, PhD student at the Division of Family Medicine and Primary Care. On February 17 you will defend your thesis "Aspects of common mental disorders in primary care" what is the main focus of the thesis?

The diagnosis exhaustion disorder accounts for the majority of all long-term sick leave in Sweden. However, a research review indicates that the scientific evidence behind the diagnosis is weak.

Depression is common in individuals with endocrine-metabolic disorders and vice versa. In a study involving 2.2 million people in the Swedish population, researchers at Karolinska Institutet confirmed that individuals with endocrine-metabolic disorders have increased rates of depression and found that there are also higher rates of depression in their siblings. The study is published in the American Journal of Psychiatry.

Patient-initiated brief admission as a complement to outpatient psychiatric care is appreciated by nurses and patients, and can reduce levels of anxiety in people with emotional instability and self-harm, a new thesis from Karolinska Institutet reports.

Six predictors could help determine the amount of lithium needed to treat patients with bipolar disorder, according to a large study led by researchers at Karolinska Institutet in Sweden. The study, published in the journal The Lancet Psychiatry, also pinpoints genetic markers that seem to influence how quickly the body eliminates lithium from its system.

Children with migration backgrounds in Sweden are less likely than other children to receive recommended treatment for psychiatric diagnoses such as ADHD and depression, a paper from Karolinska Institutet published in the journal Epidemiology and Psychiatric Sciences reports.

Scientists have analysed DNA from more than 300,000 people with and without the psychiatric disorder in the largest genetic study of schizophrenia to date and have identified a great number of specific genes that could play important roles in the psychiatric disorder. A companion paper published in parallel strengthens these findings by pointing to a similar genetic and biological basis for this disorder. Both studies are published today in the leading international journal Nature.

Sexual and gender-based harassment in the workplace can contribute to the development of mental ill-health requiring treatment with antidepressants and anti-anxiety medication, a study from Karolinska Institutet in Sweden published in the journal Occupational and Environmental Medicine reports.

Use of assisted reproductive techniques (ART) does not lead to poorer mental health in children across adolescence and young adulthood, according to a large observational study led by researchers at Karolinska Institutet. The study, published in JAMA Psychiatry, found a slightly higher risk of obsessive-compulsive disorder for those born after ART but this was explained by parental background factors.

It remains a central challenge in psychiatry to reliably judge whether a patient will respond to treatment. In a new study published in the journal Biological Psychiatry, researchers from Karolinska Institutet in Sweden and the Max Planck Institute for Human Development in Germany show that moment-to-moment fluctuations in brain activity can reliably predict whether patients with social anxiety disorder will be receptive to cognitive behavioural therapy (CBT).

Patients with bipolar disorder who experience manic episodes are more likely to show abnormal brain changes over time, according to one of the largest longitudinal brain imaging studies in its field to date. The study, led by researchers at Karolinska Institutet and University of Gothenburg in Sweden, also confirms links between bipolar disorder and accelerated brain ventricle enlargement. The findings are published online in the journal Biological Psychiatry.

The discovery that the anaesthetic ketamine can help people with severe depression has raised hopes of finding new treatment options for the disease. Researchers at Karolinska Institutet have now identified novel mechanistic insights of how the drug exerts its antidepressant effect. The findings have been published in the journal Molecular Psychiatry.

Depressed children and teenagers have an increased risk of suffering from premature death and a wide range of illnesses later in life. That is according to a large observational study by researchers at Karolinska Institutet in Sweden. The findings highlight the need to look for other potential diseases following childhood or adolescent depression. Other psychiatric conditions, such as anxiety and substance misuse, can explain part of the association. The study is published in JAMA Psychiatry.