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Researchers at the Department of Medicine, Huddinge (MedH), Magnus Tobiasson and Eva Hellström-Lindberg have together with the Nordic MDS group developed a method that makes it possible to detect early relapse of the blood cancer myelodysplastic syndrome after stem cell transplantation. The method makes it possible to initiate early treatment and thus hopefully prevent relapse. The study has been published in the Journal of Clinical Oncology.

Professor Margareta (Meta) Blombäck, one of the pioneers in the field of hemostasis and thrombosis, passed away peacefully on March 7th , 2024 in Stockholm.

During the Christmas holidays, a freezer failure occurred in the Neo building on KI's Flemingsberg campus. The automatic filling of the cryotanks with liquid nitrogen was interrupted for an unknown reason. As a result, the temperature in 16 of 19 cryogenic tanks rose and large amounts of biological research material have been destroyed. An investigation with internal and external experts is now underway to find out how this failure could have happened.

Giovanna Perinetti Casoni from the hematology unit, at the Department of Medicine, Huddinge (MedH), is defending her thesis "Regulation of cytotoxic lymphocyte effector functions" on 1 December 2023. Main supervisor is Yenan Bryceson (MedH).

Katharina Susek from the Hematology unit, at the Department of Medicine, Huddinge (MedH), is defending her thesis "Strategies to optimize natural killer cell functions in the tumor microenvironment" on 24 November 2023. Evren Alici is the main supervisor (MedH).

Maria Creignou from the Hematology Unit (HERM) at the Department of Medicine, Huddinge (MedH) is defending her thesis: "Improving prognostication for patients with myelodysplastic syndromes" on 27 October 2023. Main supervisor is Professor Eva Hellström Lindberg (MedH).

Although a simple molecule, nitric oxide is an important signal substance that helps to reduce blood pressure by relaxing the blood vessels. But how it goes about doing this has long been unclear. Researchers at Karolinska Institutet in Sweden now present an entirely novel principle that challenges the Nobel Prize-winning hypothesis that the substance signals in its gaseous form. Their findings are presented in the journal Nature Chemical Biology.

A major study published in JAMA led by researchers at Karolinska Institutet suggests that a possible cause of spontaneous brain haemorrhage could be transmitted via blood transfusion. At the same time, it is very unlikely that anyone should suffer a brain haemorrhage after receiving donated blood.

Post-doctoral fellow Amos Tuval at the Department of Oncology-Pathology has been selected by the American Society of Hematology (ASH) to receive the 2023 ASH Global Research Award. Amos is one of 12 talented early-career investigators selected for this honor.

Maria Karvouni from the Center for Hematology and Regenerative Medicine (HERM) at the Department of Medicine, Huddinge (MedH) is defending her thesis: "Cellular and personalized therapies in Multiple Myeloma with special emphasis on retargeted NK cells" 16 June 2023. Main supervisor is Evren Alici (MedH).

How should healthcare providers identify bacteria or other pathogens in the blood of sepsis patients as quickly as possible? Volkan Özenci is focusing on this in his research. This article is part of an in-depth feature from KI's popular science magazine Medicinsk Vetenskap.

Some patients get sepsis because of hospital-acquired infections. A new digital system is now being implemented to find these patients by constantly scanning medical records for signs of sepsis. This article is part of an in-depth feature from KI's popular science magazine Medicinsk Vetenskap.

Just over two years ago, Arne Persson had a bad fall while walking his dog in the woods. He struck his coccyx badly but was able to get home. The pain just grew and grew over the next few days, so in the end he went to A&E at the hospital. After an X-ray, he was sent home because nothing was broken. This article is part of an in-depth feature from KI's popular science magazine Medicinsk Vetenskap.

Petra Kormo’s second baby was born on Wednesday, 4 January 2017. Everything went well with the birth, but Petra developed a fever after she arrived home. She felt weaker and sicker for every day that passed. This article is part of an in-depth feature from KI's popular science magazine Medicinsk Vetenskap.

Sepsis has a way of flying under the radar. Public awareness of the life-threatening disease is low, and official statistics are misleading. Now researchers are using special alarm systems and AI to increase detection. This article is part of an in-depth feature from KI's popular science magazine Medicinsk Vetenskap.

The risk of being infected by parvovirus is elevated in those people who have blood group Rh(D), according to a study published in The Journal of Infectious Diseases by researchers from Karolinska Institutet in collaboration with Octapharma.

A study from Karolinska Institutet sheds new light on the question of whether the sex and previous pregnancy of blood donors affects survival in patients who receive red blood cell transfusions. According to the study, which is published in JAMA Internal Medicine, neither of these factors has such an effect, after accounting for the lower haemoglobin levels in blood from women.

The causes of complex diseases can be identified by representing them in the form of mathematically produced networks. This method was used to find bacteria that drive atopic dermatitis, for example.

Researchers at Karolinska Institutet have investigated the use of low dose venetoclax, an experimental drug, for the treatment of the heterogeneous cancer disease multiple myeloma in patients who had relapsed on standard therapies. The findings are published in the American Journal of Hematology and provide new hope for the treatment of multiple myeloma.

Researchers at Karolinska Institutet have found links between certain blood groups and a total of 49 diseases, including a new finding that having blood group B seems to be a protective factor against kidney stones. The study, which includes data on more than five million people and over 1,000 diseases, confirms previously identified connections between certain blood groups and increased risk of blood clots, bleeding conditions or pregnancy-induced hypertension. The result is published in eLife.

The Tobias Foundation grant in 2020 has been awarded to Magnus Tobiasson and Eva Hellström Lindberg, both researchers at Karolinska Institutet. The grant amounts to SEK 10 million over a five-year period. It will support research on early detection of relapse after stem cell transplantation for patients with myelodysplastic syndrome.

A simple blood test may help predict which people with multiple sclerosis (MS) will get worse during the following year, according to a study by researchers at Karolinska Institutet in Sweden published online in Neurology, the medical journal of the American Academy of Neurology.

Acute porphyria is a group of uncommon diseases that can cause severe, potentially life-threatening attacks of abdominal pain, nausea, vomiting and paralysis. Liver transplantation is currently the only effective treatment available for the most seriously afflicted patients. A clinical trial conducted in collaboration with researchers at Karolinska Institutet in Sweden now shows that a new drug candidate can prevent attacks in these patients. The study is published in The New England Journal of

In contrast to what has been previously believed, development of blood stem cells to mast cells, a type of specialised immune cell, does not depend on a growth factor called stem cell factor. This has been demonstrated in a new collaborative study by researchers at Karolinska Institutet and Uppsala University, and published in the scientific journal Blood. The results could pave the way for new treatments for certain types of blood diseases.

A new mechanism that regulates the way blood vessels grow and connect to each other has been discovered by an international team of researchers at Karolinska Institutet, and Heinrich Heine University Düsseldorf, Germany. The knowledge might open up new opportunities for future cancer therapy. The study is published in the scientific journal PNAS.