Published: 16-03-2021 12:48 | Updated: 16-03-2021 13:06

New study on the benefits and harms of community-based tuberculosis screening

Planning and implementing public health interventions, such as screening, requires careful consideration of the benefits and harms for the people targeted, communities and the health system more broadly.
In a study recently published in PLOS One, researchers at Karolinska Institutet aimed to understand how experts perceive the benefits and harms of community-based tuberculosis screening, also known as active case-finding, for people with presumptive tuberculosis and communities.

“Diving into experts’ views, we learned that it is important to consider the benefits and harms of community-based tuberculosis (TB) screening not just in the planning phase but throughout the screening pathway to be able to reap the benefits and mitigate harms”, says Olivia Biermann, PhD student and first author of the publication.

On the one hand, the perceived benefits of screening included reaching vulnerable populations, reducing patient costs, helping raise awareness for TB among individuals and engaging communities. On the other hand, screening was also described as a ‘double-edged sword’ that can cause harms like stigma and discrimination, false-positive diagnoses, as well as other unintended negative consequences.”

The World Health Organization and the Sustainable Development Goals emphasize the need for such screening in the fight against tuberculosis, as it is estimated that one third of people with the disease are never diagnosed and treated. Yet, the evidence base for the benefits of community-based screening for individuals is relatively limited. Policy decisions still need to be made, though, and rely on experts’ perceptions of the benefits and harms.

“This study opened my eyes to the challenges in making judgements on the benefits and harms of screening, as they are difficult to quantify (e.g., increased stigma) or compare (e.g., reduced transmission versus false-positive results). Evaluating the potential benefits and harms of TB screening may be even more challenging in high Tb burden settings, as many low- and middle-income countries do not have established processes for the development of screening policies in place”

The results of this study relevant for planning and implementing community-based TB screening, but even COVID-19 screening. It is important to avoid ‘screeningitis’ that does more harm than good.”, says Olivia Biermann.

First author Olivia Biermann about the findings of the study


Biermann O, Klüppelberg R, Lönnroth K, Viney K, Caws M, Atkins S. 'A double-edged sword': Perceived benefits and harms of active case-finding for people with presumptive tuberculosis and communities-A qualitative study based on expert interviews. PLOS One. 2021;16(3):e0247568. doi: 10.1371/journal.pone.0247568.


Olivia Biermann Postdoctoral Researcher