Lennart Nilsson Award 2024 is awarded to Csaba Adori

Csaba Adori's detailed images and 3D movies of tissues allow the viewer to take a visual journey through several of the body’s organs. This has significantly contributed to increasing our understanding of the structure of various organs and the development of disorders such as Alzheimer’s disease, fatty liver disease (MAFLD), and cancer.

Csaba, what does it feel like to receive the award?

"The nomination itself was already a great honor to me and I would like to express my gratitude to all those esteemed colleagues who initiated it and joined my nomination.

I am also deeply thankful to all the colleagues who helped me over the past eight years in the field of 3D microscopy: those who inspired and taught me, provided various tissue samples for imaging, and contributed to funding the essential infrastructure. 

This award gives med encouragement and reinforces my commitment to continue the journey with 3D microscopy, which hasn't always been easy. Lastly, I am particularly delighted that the scientific, educational, and aesthetic potential of this imaging approach has been recognized by this award. In an era of single-cell and omics technologies, we should not forget that cells and biomolecules are spatially organized within tissues, and these tissue structures exist in three dimensions in the organisms."

Do you have any new projects in the works?

"My primary research interest lies in the noradrenergic system, encompassing both the peripheral and central nervous systems. In 2021, utilizing whole-mount immuno-imaging and tissue clearing techniques, we discovered that the sympathetic (noradrenergic) nerves undergo selective and progressive neurodegeneration in fatty liver disease, observed in both humans and an experimental animal model. Following up this work, I am currently studying the functional implications of this degeneration. Furthermore, through various animal models, we are investigating whether this nerve degeneration is reversible after treating obese animals with compounds known for their ‘anti-obesity’ effects. My other project involves following up on my 2022 paper about the 3D cytoarchitecture and tau pathology of the human noradrenergic nucleus locus coeruleus. In both projects, 3D plays a crucial role. Additionally, I am involved in several collaborative projects."