Large grant for research on how weight cycling affects cardiovascular health
Mikael Rydén, Professor at the Department of Medicine, Huddinge, Karolinska Institutet, has been awarded a grant of USD 9 million from the Leducq Foundation.
The grant is to be used within the international ADAMANT network, coordinated by Mikael Rydén together with Edward A. Fisher at NYU Grossman School of Medicine. ADAMANT brings together researchers from Europe and the United States and will investigate how changes in body fat influence the development of atherosclerosis.
Particular focus is placed on so-called weight cycling, that is, repeated periods of weight loss and weight regain, which are suspected to increase inflammation in the body and accelerate the build-up of plaque in the blood vessels.
The network will combine studies in animal models with analyses of human blood and tissue samples to better understand the biological mechanisms underlying the link between adipose tissue and cardiovascular disease.
“This network allows us to study how adipose tissue affects vascular health and why different approaches to weight loss may have different effects on cardiovascular risk. Our goal is to contribute to safer, more personalised weight-loss strategies that protect heart health in the long term in a real-world setting where weight cycling is common,” says Mikael Rydén, Professor at the Department of Medicine, Huddinge.
About ADAMANT
Adipose tissue–Driven Atherosclerosis Mechanisms Across cliNical interventions and Translational models
Coordinators:
- Mikael RYDÉN, Karolinska Institutet (Sweden)
- Edward A. FISHER, NYU Grossman School of Medicine (USA)
Members:
- Ada WEINSTOCK, University of Chicago Pritzker School of Medicine (USA)
- Jacob Fog BENTZON, Aarhus University (Denmark)
- Chiara GIANNARELLI, NYU Grossman School of Medicine (USA)
- Paul COHEN, The Rockefeller University (USA)