Lectures and seminars CIM Seminar series - "Immune endotypes and host-directed therapies in tuberculosis (TB)"

11-06-2026 11:00 am - 12:00 pm Add to iCal
Campus Flemingsberg von Behring, Alfred Nobels allé 8

Welcome to a seminar within the seminar series organized by the Center for Infectious Medicine (CIM) at the Department of Medicine, Huddinge (MedH).

Speaker 

Andrew R. Di Nardo, Baylor College of Medicine, Houston, Texas.

Title 

Immune endotypes and host-directed therapies in tuberculosis (TB).

Host

Susanna Brighenti, Center for Infectious Medicine (CIM), Department of Medicine, Huddinge (MedH), Karolinska Institutet.

About the speaker

Dr. Andrew R. DiNardo, MD, PhD, is an Associate Professor of Infectious Diseases at Baylor College of Medicine in Houston, Texas. He is a physician scientist whose research focuses on the immunology of tuberculosis and co-infections, particularly the epigenetic regulation of host immune responses. He has pioneered work on molecular endotypes in tuberculosis with implications for host-directed therapies.

His research integrates clinical practice with translational and global health approaches to understand long-lasting immune changes in tuberculosis and to improve treatment and vaccine strategies.

Dr. DiNardo received his MD from Wayne State University School of Medicine and completed his residency in internal medicine at the University of Pennsylvania, followed by a fellowship in infectious diseases at Baylor College of Medicine. He also earned a PhD from Radboud University Medical Center in the Netherlands.

Selected publications:

  1. DNA hyper-methylation during Tuberculosis dampens host immune responsiveness. Journal of Clinical Investigation. 2020 
    Pubmed PMID: 32125282.
  2. Postinfectious Epigenetic Immune Modifications - A Double-Edged Sword. NEJM. 2021
    Pubmed PMID: 33471978.
  3. Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes. European Respiratory Journal. 2022 
    Pubmed PMID: 35169026.
  4. TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis-induced immune tolerance. PNAS. 2024 
    Pubmed PMID: 39348545.
  5. Immune endotypes in tuberculosis: Keys to decoding disease complexity. Journal of Internal Medicine. 2026
    PubMed PMID: 41930636