New thesis reveals link between creatine metabolism and unhealthy fat tissue growth

What is the main focus of your thesis?

My thesis explores how creatine, a molecule better known for boosting athletic performance, also plays a vital role in fat tissue biology. Specifically, I studied how changes in creatine metabolism in human white fat cells contribute to inflammation, fat storage, and metabolic problems in obesity.

Which are the most important results?

We discovered that a key enzyme, creatine kinase B (CKB), is consistently reduced in the fat tissue of people with obesity. This loss of CKB disrupts energy balance inside fat cells, leading to an overproduction of certain molecules that trigger inflammation and immune cell infiltration. We also uncovered how obesity-related stress in cells “switches off” the CKB gene through a combination of DNA methylation and a stress-response pathway. Finally, we found that early loss of CKB during fat cell development reprograms the cells to store more fat, via a chain reaction involving the AKT and ChREBP proteins.

How can this new knowledge contribute to the improvement of people’s health?

By revealing a previously unknown link between creatine metabolism and unhealthy fat tissue expansion, our work opens new possibilities for tackling obesity-related diseases. Targeting CKB, either by preventing its loss or boosting its activity, could help reduce inflammation, improve insulin sensitivity, and limit harmful fat storage.

What are your future ambitions? 

After graduation, I aim to transition into the Biotech/Pharma industry, where I can apply the skills, I’ve developed over the years to research in an industry setting. My goal is to contribute to the discovery and development of new pharmaceutical treatments, helping to translate science into meaningful impact for patients.

Dissertation

Friday, 3 October at 09:30, the Erna Möller hall, Neo, Blickagången 16, Flemingsberg.

Thesis

The Role of Creatine Metabolism in Human White Adipose Tissue