Published: 17-01-2020 11:46 | Updated: 17-01-2020 12:10
New publication from BioNut in Nature Communications
The transcription factor DAF-16/FOXO mediates a wide variety of aging-preventive responses by driving the expression of stress-resistance and longevity promoting genes. Ilke Sen and other members of the Riedel lab could show that transcriptional initiation at many DAF-16/FOXO target genes depends on dephosphorylation of SPT-5 by Protein Phosphatase 4.
Sen, I., Zhou, X., Chernobrovkin, A., Puerta-Cavanzo, N., Kanno, T., Salignon, J., Stoehr, A., Lin, X., Baskaner, B., Brandenburg, S., Björkegren, C., Zubarev, R., Riedel, C. (2020). DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes Nature Communications 11(1), 138.