Published: 02-05-2012 00:00 | Updated: 10-06-2015 14:12

Higher maternal age increases risk of autism

In a new study from Karolinska Institutet and the Institute of Psychiatry at King's College London, researchers have analyzed past studies to investigate possible associations between maternal age and autism spectrum disorder. While much research has been done to identify potential genetic causes of autism, the current analysis suggests that non-heritable and environmental factors may also play a role in children's risk for autism.

The researchers compared the risk of autism in different groups of material age hey found that children of mothers older than 35 years had 30 percent increased risk for autism. Children of mothers under 20 had the lowest risk of developing autism. The association between advancing maternal age and risk for autism was stronger for male offspring and children diagnosed in more recent years.

The analysis included 25,687 cases of autism spectrum disorder and over 8.6 million control subjects, drawn from the 16 epidemiological papers that fit inclusion criteria for the study as defined by the investigators. The researchers identified and discussed several potential underlying causes of the association between maternal age and risk for autism, such as increased occurrence of gene alteration during the aging process and the effects of exposure to environmental toxins over time.

"The study makes us confident there is an increased risk for autism associated with older maternal age, even though we do not know what the mechanism is", says lead author Sven Sandin of Karolinska Institutet and the Institute of Psychiatry at King's College London.

All studies were controlled for paternal age which is an independent risk factor for autism. This finding adds to the understanding that older age of the parents could have consequences to the health of their children.


Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis.
Sandin S, Hultman C, Kolevzon A, Gross R, MacCabe J, Reichenberg A
J Am Acad Child Adolesc Psychiatry 2012 May;51(5):477-486.e1