Published: 15-05-2014 11:15 | Updated: 28-03-2022 15:25

Gunilla Karlsson Hedestam receives NIH-grant

Professor Gunilla Karlsson Hedestam at the Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet, receives a PO1 grant from the National Institutes of Health (NIH).

The total amount of the grant is 80 million SEK, to be shared between four research groups. In addition to Karlsson Hedestam, L. Shapiro at Columbia University, Yuxing Li at TSRI and Richard Wyatt at TSRI share the grant. Twenty million SEK is awarded to Karlsson Hedestam’s group over five years, 2014–2019.

The aim of the project is to analyse, at a high level of resolution, immune responses elicited by new generation soluble HIV-1 glycoproteins. The research group at MTC will investigate B cell affinity maturation processes and recruitment of B cells into long-lived memory compartments. The evolution of specific antibody lineages will be examined by single cell and next-generation sequencing to further understand host antibody responses to foreign protein antigens.