Lectures and seminars PhD student seminar: Stephen Nash

Description

The estimands framework was introduced by the European Medicines Agency (EMA) in 2020. The framework provides a structured way to align objectives, study design, and statistical analysis of randomised clinical trials. In particular, there is an emphasis on describing the relevant estimands in a transparent and structured way, and for thinking about strategies to handle what are called intercurrent events: things which happen after randomisation which affect the interpretability or availability of the final outcome measure. This talk will seek to explain the language used in the estimands framework, and how this relates to language used in causal modelling (of observational data).