Lectures and seminars Faculty event: Patrick Schnell

Title 

Applying the EMA estimands framework to randomized trials with treatment switching and discontinuation

Abstract

A key component in the EMA estimands guidance for clinical trials is the requirement for a plan for handling intercurrent events (occurring between intervention and outcome) such as treatment switching or discontinuation. This talk will give examples of estimands and statistical analyses for the two less widely understood strategies described by the guidance. In the first example, a counterfactual strategy is used to ask what the effect of a treatment would be if the treatment switching allowed in the trial were made impossible. In the second, a principal stratum strategy is used to ask what the effect of a treatment is among those who can tolerate it.

About the speaker

Patrick Schnell is an Associate Professor of Biostatistics at The Ohio State University College of Public Health, and has been visiting MEB for the past academic year. His primary research interests are clinical trials, causal inference, and cancer.

Faculty lunch

Join the faculty event in Wargentin! After the seminar, the faculty lunch will be served in Ljusgården. The faculty lunches are intended for employees at MEB, and a monthly net salary deduction of 260 SEK will be made for those who work here 20% or more. If you have any questions about the lunch or specific dietary needs due to allergies, etc., please contact internservice@meb.ki.se. If you won’t be participating in the lunches for all or part of the spring term, our new routine is that you need to contact hr-support@meb.ki.se at the start of a new term, to be removed from the list. Retroactive adjustments will not be possible.  

Please, check the labeling on the salads not to take special diet foods that were pre-ordered by your colleagues.