Susanne Schlisio and collaborators publish in Cell Reports
The Susanne Schlisio group at the Department of Microbiology, Tumour and Cell Biology (MTC) and collaborators have published in Cell Reports.
It has been known for decades that hypoxia and hydroxylase inhibition regulate expression and activity of the p53 tumor suppressor. In this paper a direct mechanism of how p53 protein stability is regulated by oxygen-sensing enzymes through a post-translational modification is uncovered. Thus, a direct mechanism of how oxygen-sensing pathways mediates p53 tumor suppression has been identified.
PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.
Cell Rep 2018 Jul;24(5):1316-1329