Published: 04-10-2023 11:15 | Updated: 04-10-2023 11:15

New thesis on proteins that influence the progression of Alzheimer's disease

Hi Michael Axenhus, PhD student at the Division of Neurogeriatrics. On October 20 you will defend your thesis ”Characterization of proteins involved in disease progression in Alzheimer disease”, what is the main focus of the thesis?

Michael Axenhus, Divsion of Neurogeriatrics. Photo: Private.

My thesis focuses on proteins that influence the progression of Alzheimer's disease. Understanding which proteins are crucial for the disease is vital as it unravels the mechanisms driving it, potentially paving the way for the development of new treatments. 

Which are the most important results?  

We have identified significant findings in our research. Firstly, we observed an increase in Huntingtin, a protein associated with Huntington's disease, in both the brain tissues of individuals with Alzheimer's disease and in a mouse model for Alzheimer's. Additionally, we discovered elevated levels of a different protein, DDX24, in the brains of Alzheimer's patients. Lastly, our investigation into the development of new neurons in Alzheimer's disease revealed evidence of altered neuronal growth during disease progression. 

How can this new knowledge contribute to the improvement of people’s health?  

Alzheimer's disease stands as one of the most devastating illnesses humanity faces, posing a significant healthcare challenge. Understanding the disease's underlying mechanisms marks the initial step toward developing novel treatments. Fundamental research of this kind is indispensable; it lays the foundation essential for conquering Alzheimer's disease. 

What’s in the future for you? Will you continue to conduct research? 

As a physician, balancing research with clinical work presents challenges, yet I am steadfast in my commitment to academic pursuits. I plan to persist in both research and clinical practice, aiming to broaden my scientific horizons while actively engaging in patient care. My immediate plan involves a postdoctoral position to enhance my scientific expertise. 


Michael Axenhus Affiliated to Research