Published: 11-11-2020 09:42 | Updated: 13-11-2020 10:32

New thesis about proteomics in Alzheimer disease

Hi Hazal Haytural, PhD student at the Division of Neurogeriatrics, NVS! On November 27 you will defend your thesis “Unraveling pathogenic proteins and pathways in Alzheimer disease: A focus on proteomics”. What’s the main focus of the thesis?

Hazal Haytural, PhD student at the Division of Neurogeriatrics, NVS.

My thesis focuses on investigating proteins that could be involved in Alzheimer disease (AD), which is the most common type of dementia. To study the alterations occurring in AD brains, we mainly used invaluable patient material.

Which are the most important results? 

Our findings revealed alterations in several mechanisms that are crucial for brain function in AD. Additionally, our studies on a specific region involved in memory formation showed that presynaptic proteins are decreased in AD, suggesting that they could be important future pharmacological targets.

How can this new knowledge contribute to the improvement of people’s health? 

This thesis increased our understanding on the involvement of different mechanisms in AD pathogenesis. Future studies on this work may facilitate the development of new biomarkers and therapeutic strategies for AD.

What's in the future for you? Will you keep on conducting research?

Working with patient material is fascinating and can help us understand this disease better. I would like to continue working on the field of dementia.