Lectures and seminars Welcome to lunch seminar -Organoids model human disease in 3D and 2D
Welcome to lunch seminar with Prof. Dr. Hans Clevers Organoids model human disease in 3D and 2D
Light lunch from 11:45 on a first-come, first-served basis, no registration
Host: Prof. Dr. Charlotte Thålin, Karolinska Institutet & Danderyd Hospital
Organoids of individual patients are like avatars: they predict which drug will work best for the patient from which they derive.
Hans Clevers characterized the molecular effectors of the Wnt pathway: the TCF transcription factors. His group described the role of Wnt in (intestinal) stem cell biology and cancer, eventually leading to the discovery of LGR5 as a novel stem cell marker. This led him to pioneer tissue stem cell-based organoids, 3-dimensional in vitro structures that behave anatomically and molecularly like the organ from which they are derived. Organoid biology has revolutionized the way we approach human biology.
Hans Clevers obtained his MD and PhD degrees from the University of Utrecht, the Netherlands. He holds a professorship in Molecular Genetics from the University of Utrecht. He previously held directorship/president positions at the Hubrecht Institute, the Royal Netherlands Academy of Arts and Sciences and the Princess Maxima Center for pediatric oncology. He has served in the Supervisory Board (2019-2022) and as head of Roche’s Pharma Research & Early Development (pRED; 2022-2025). During this time, he oversaw the establishment of Roche's Institute of Human Biology (IHB) in Basel. He currently supervises his research groups at the Hubrecht Institute and the Princess Máxima Center.