Lectures and seminars StratRegen Seminar Series with Steven A. Goldman

Steven A. Goldman is Professor of Neuroscience and Neurology at the University of Copenhagen, where he is Co-Director of its Center for Basic and Translational Neuroscience, and a consultant at Copenhagen University Hospital. He has a secondary appointment at the University of Rochester in the US, where he is the URMC Distinguished Professor and Co-Director of its Center for Translational Neuromedicine. He moved to Copenhagen in 2014 from Rochester, having received the Novo Nordisk Laureate Award from the Novo Nordisk Fondation in Denmark. He was recruited to Copenhagen to establish its new Center in Basic and Translational Neuroscience. Goldman is a summa cum laude graduate of the University of Pennsylvania, with BA degrees in Biology and Psychology. He obtained his PhD with Fernando Nottebohm at the Rockefeller University in 1983, and his MD from Cornell in 1984. Goldman interned in Medicine (1984-85) and did his residency in Neurology (1985-88) at New York Hospital-Cornell and Memorial Sloan-Kettering Cancer Center. He joined the Cornell faculty in 1988, and became a tenured Professor in 1997, at age 39; he is board certified in neurology and neuro-oncology. He moved to Rochester in 2003.

Currently, his laboratory seeks to use neural precursor cells to repair the damaged or dysfunctional brain and spinal cord. In previous studies, he and his colleagues discovered that the human forebrain harbors persistent neural progenitor cells, in both the ventricular epithelium and brain parenchyma. They have since identified discrete neurotrophic agents that act upon these adult neuronal and oligodendroglial progenitor cells to yield their expansion and differentiation. Among the studies he is collaborating on is one that would be the first transplantation of native progenitor cells into the damaged central nervous system (CNS). If successful, these studies should provide a firm foundation for clinical trials of neural stem cell-based therapy. Goldman's lab is also attempting to better define the cell types and molecules involved in cell migration in adult brain tissue. Only by better understanding this process will it be possible to modulate the destinations of implanted or induced brain cells. In all of this work, the goal is to induce neuronal and oligodendrocytic recruitment in otherwise non-regenerative regions of the adult brain and spinal cord, and to develop these strategies as therapeutic modalities.

Publications

Charting the transition from in vitro gliogenesis to the in vivo maturation of human glial progenitor cells transplanted into the hypomyelinated mouse brain.
Mariani JN, Schanz SJ, Mansky B, Wei X, Long CC, Chandler-Militello D, Aichelman HE, Huynh NPT, Goldman SA
Nat Commun 2026 Apr;():

In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells.
Cona A, Newbold E, Kesmen D, Snape R, Danner J, White N, Borden W, Iseson A, Schanz SJ, Chandler-Militello D, Li X, Cano JC, Mariani JN, Nedergaard M, Benraiss A, Goldman SA
bioRxiv 2025 Jul;():

Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells.
Mariani JN, Mansky B, Madsen PM, Salinas D, Kesmen D, Huynh NPT, Kuypers NJ, Kesel ER, Bates J, Payne C, Chandler-Militello D, Benraiss A, Goldman SA
Nat Commun 2024 May;15(1):3873

Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain.
Vieira R, Mariani JN, Huynh NPT, Stephensen HJT, Solly R, Tate A, Schanz S, Cotrupi N, Mousaei M, Sporring J, Benraiss A, Goldman SA
Nat Biotechnol 2024 May;42(5):719-730

Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.
Osipovitch M, Asenjo Martinez A, Mariani JN, Cornwell A, Dhaliwal S, Zou L, Chandler-Militello D, Wang S, Li X, Benraiss SJ, Agate R, Lampp A, Benraiss A, Windrem MS, Goldman SA
Cell Stem Cell 2019 Jan;24(1):107-122.e7

Sandwiches and coffee will be provided.