Lectures and seminars Seminar: "Combining AlphaFold with SAXS for partially or intrinsically disordered proteins"
Welcome to a seminar on 21 August 2026 with Dr Mattia Rocco, retired from IRCCS Azienda Ospedaliera Metropolitana San Martino, Genova, Italy. The seminar is held in Biomedicum, KI Campus Solna.
AI tools like AlphaFold (AF) are transforming structural biology. However, they still struggle with intrinsically disordered regions, flexible linker-connected domains, and conformational changes driven by environmental conditions, limitations that are difficult to resolve computationally alone.
A recent method combines predicted or experimentally determined protein domains with flexible linkers to generate model ensembles refined against small-angle X-ray scattering (SAXS) data [Brookes et al., 2023].
This approach is now available through the public web platform SAXS-A-FOLD.
The case of a supposedly fully intrinsically disordered protein will also be shown, manuscript in submission right now.