Lectures and seminars StratRegen Seminar Series with Lars Velten
Welcome to a new seminar in the StratRegen Lunch Seminar Series on Wednesday 19th of November 2025, 12.00-13.00 in Peter Reichard lecture hall, Biomedicum, Campus Solna.

Title: Functional genomics of blood formation: Epimutational lineage tracing & synthetic enhancers
Speaker: Lars Velten, Group Leader, Center for Genomic Regulation (CRG), Barcelona
Publications
Clonal tracing with somatic epimutations reveals dynamics of blood ageing.
Scherer M, Singh I, Braun MM, Szu-Tu C, Sanchez Sanchez P, Lindenhofer D, Jakobsen NA, Körber V, Kardorff M, Nitsch L, Kautz P, Rühle J, Bianchi A, Cozzuto L, Frömel R, Beneyto-Calabuig S, Lareau C, Satpathy AT, Beekman R, Steinmetz LM, Raffel S, Ludwig LS, Vyas P, Rodriguez-Fraticelli A, Velten L
Nature 2025 Jul;643(8071):478-487
Design principles of cell-state-specific enhancers in hematopoiesis.
Frömel R, Rühle J, Bernal Martinez A, Szu-Tu C, Pacheco Pastor F, Martinez-Corral R, Velten L
Cell 2025 Jun;188(12):3202-3218.e21
Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia.
Beneyto-Calabuig S, Merbach AK, Kniffka JA, Antes M, Szu-Tu C, Rohde C, Waclawiczek A, Stelmach P, Gräßle S, Pervan P, Janssen M, Landry JJM, Benes V, Jauch A, Brough M, Bauer M, Besenbeck B, Felden J, Bäumer S, Hundemer M, Sauer T, Pabst C, Wickenhauser C, Angenendt L, Schliemann C, Trumpp A, Haas S, Scherer M, Raffel S, Müller-Tidow C, Velten L
Cell Stem Cell 2023 May;30(5):706-721.e8
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana S, Vonficht D, Jopp-Saile L, Raffel S, Lutz R, Leonce D, Antes M, Hernández-Malmierca P, Ordoñez-Rueda D, Ramasz B, Boch T, Jann JC, Nowak D, Hofmann WK, Müller-Tidow C, Hübschmann D, Alexandrov T, Benes V, Trumpp A, Paulsen M, Velten L, Haas S
Nat Immunol 2021 Dec;22(12):1577-1589
Sandwiches and coffee will be provided.
Host
Enric Llorens Bobadilla
Assistant ProfessorElif Eroglu
Principal ResearcherStratRegen supports researchers, research programs and infrastructure at the Karolinska Institutet (KI) within the field of stem cells and regenerative medicine based on scope, quality, and the potential to strengthen and develop the field.