Lectures and seminars SRP Diabetes & KIRCNET Seminar
“Lipid metabolism in thermogenic adipose tissues”
Jörg Heeren, Professor, University Medical Centre Hamburg-Eppendorf, Germany
The presence and activity of brown adipose tissue (BAT) correlate with improved metabolic health, lower body weight and beneficial cardiovascular outcomes in humans. The activity of BAT declines with ageing and is reduced in obese states both in rodents and in humans. Accordingly, activating thermogenic adipose tissues or preventing the obesity- and ageing-induced decrease in thermogenic function have been proposed as a strategy to combat cardiometabolic diseases. Based on advanced technologies to capture the organ-specific processing of lipids and metabolites, we deciphered the molecular mechanisms of glucose and lipid processing in white and brown adipocytes in transgenic mouse models. In the lecture, I will present our latest findings on lipoprotein and lipid uptake and their relevance to BAT function and tissue remodeling inresponse to cold exposure. In addition, the molecular and cellular mechanisms that initiate inflammatory adipose tissue degeneration observed under conditions of obesity and ageing and their relevance to systemic energy metabolism will be presented.
Registration to Arja.Kants@ki.se latest 24.9 for the mingle after the seminar.
Host: Carolina Hagberg / SRP Diabetes & KIRCNET