Lectures and seminars Rewiring the Adult Brain: From Mossy Fiber Sprouting to Memory Circuits
Frontiers in Neural Circuits seminar series: with Csaba Földy. In room Ragnar Granit, Biomedicum on May 21 at 11:00.
Welcome all members of Karolinska Institutet, as well as researchers and trainees from KTH Royal Institute of Technology, Stockholm University, and other universities in the Stockholm region. We warmly encourage students, postdocs, and faculty to attend and engage with our distinguished guest.
Speaker:
Csaba Földy, Brain Research Institute, Zürich, Switzerland.
Time: 21 May, 11:00–12:00
Location: Peter Reichard Lecture Hall, Biomedicum (level 3)
Title: Rewiring the Adult Brain: From Mossy Fiber Sprouting to Memory Circuits
Abstract
Contrary to traditional belief, axon growth and circuit formation do not only occur in the developing brain, but also in the adult brain. However, the underlying mechanisms remain elusive. Understanding these mechanisms could provide insight into fundamental questions, such as how brain circuits are maintained throughout life and how brain rewiring might be used for therapeutic and repair purposes. Recent work from our laboratory has identified two bHLH transcription regulators, Id2 and Ascl4, that can reactivate axonal wiring in mature neurons of the naive adult brain. In this talk, I will discuss the underlying molecular programs and implications of this new wiring in the context of the hippocampus. These results suggest the existence of a transcriptomic program for adult brain wiring that may be applicable to different neuron types. They also demonstrate that adult brain rewiring can enhance cognitive functions, such as learning and memory, via the rewired hippocampal projection system.
Recent publications
Molecular Signatures of Id2- and Ascl4-Induced Wiring of Adult Hippocampal Neurons.
Seng C, Tamás B, Kaur R, Luo W, Földy C
J Neurosci 2026 Feb;46(7):
Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4.
Luo W, Egger M, Cruz-Ochoa N, Tse A, Maloveczky G, Tamás B, Lukacsovich D, Seng C, Amrein I, Lukacsovich T, Wolfer D, Földy C
PNAS Nexus 2024 May;3(5):pgae174
Commissural dentate granule cell projections and their rapid formation in the adult brain.
Egger M, Luo W, Cruz-Ochoa N, Lukacsovich D, Varga C, Que L, Maloveczky G, Winterer J, Kaur R, Lukacsovich T, Földy C
PNAS Nexus 2023 Apr;2(4):pgad088
Pcdh11x controls target specification of mossy fiber sprouting.
Luo W, Cruz-Ochoa NA, Seng C, Egger M, Lukacsovich D, Lukacsovich T, Földy C
Front Neurosci 2022 ;16():888362
Circuit formation in the adult brain.
Seng C, Luo W, Földy C
Eur J Neurosci 2022 Aug;56(3):4187-4213
Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.
Luo W, Egger M, Domonkos A, Que L, Lukacsovich D, Cruz-Ochoa NA, Szőcs S, Seng C, Arszovszki A, Sipos E, Amrein I, Winterer J, Lukacsovich T, Szabadics J, Wolfer DP, Varga C, Földy C
Proc Natl Acad Sci U S A 2021 Oct;118(40):
Refreshments
Sandwiches and coffee will be provided.
Registration
No registration is needed.