Lectures and seminars From cell to systems: Navigating the Complex Landscape of Autism Spectrum Disorders
Frontiers in Neural Circuits seminar series: with Gaia Novarino. In room Ragnar Granit, Biomedicum on April 23 at 11:00.
Welcome all members of Karolinska Institutet, as well as researchers and trainees from KTH Royal Institute of Technology, Stockholm University, and other universities in the Stockholm region. We warmly encourage students, postdocs, and faculty to attend and engage with our distinguished guest.
Speaker:
Gaia Novarino, Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria
Time: 23 April, 11:00–12:00
Location: Ragnar Granit Lecture Hall, Biomedicum (level 3)
Title: From cell to systems: Navigating the Complex Landscape of Autism Spectrum Disorders
Abstract
Autism spectrum disorders (ASD) are a heterogeneous group of disorders rooted in genetic bases. Although genetic studies have identified many ASD-risk genes over the past few years, it remains essentially unknown whether mutations in different genes result in similar molecular and cellular states within the brain. Over the past years, we have generated a large cohort of ASD mouse models carrying mutations in top, high-risk ASD genes. The cohort includes 11 mouse lines and span chromatin remodelers, ubiquitin-related genes, metabolically relevant genes, and synaptic proteins. Employing these validated mouse models, we performed simultaneous single nucleus RNA and ATAC sequencing across brain regions, developmental stages, and sexes, totaling over 300 samples. We achieved this by pioneering an approach that allowed us to sequence RNA and DNA from the same nucleus on a large scale. With this unique dataset, we could address precise questions regarding convergence and divergences across different ASD models, time windows affected, and sex differences.
Lab website: https://novarinolab.wordpress.com/
Recent publications
Imaging brain tissue architecture across millimeter to nanometer scales.
Michalska JM, Lyudchik J, Velicky P, Štefaničková H, Watson JF, Cenameri A, Sommer C, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino G, Jonas P, Danzl JG
Nat Biotechnol 2024 Jul;42(7):1051-1064
Dense 4D nanoscale reconstruction of living brain tissue.
Velicky P, Miguel E, Michalska JM, Lyudchik J, Wei D, Lin Z, Watson JF, Troidl J, Beyer J, Ben-Simon Y, Sommer C, Jahr W, Cenameri A, Broichhagen J, Grant SGN, Jonas P, Novarino G, Pfister H, Bickel B, Danzl JG
Nat Methods 2023 Aug;20(8):1256-1265
Effects of urban living environments on mental health in adults.
Xu J, Liu N, Polemiti E, Garcia-Mondragon L, Tang J, Liu X, Lett T, Yu L, Nöthen MM, Feng J, Yu C, Marquand A, Schumann G,
Nat Med 2023 Jun;29(6):1456-1467
Large neutral amino acid levels tune perinatal neuronal excitability and survival.
Knaus LS, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M, Schwarz LA, Gorkiewicz S, Amberg N, Pauler FM, Knittl-Frank C, Tassinari M, Maulide N, Rülicke T, Menche J, Hippenmeyer S, Novarino G
Cell 2023 Apr;186(9):1950-1967.e25
Refreshments
Sandwiches and coffee will be provided.
Registration
No registration is needed.