Lectures and seminars Faculty event: Stephen Nash

Title 

Estimands framework for clinical trials

Abstract

Designing a trial using the EMA estimands framework

The estimands framework was introduced by the European Medicines Agency (EMA) in 2020. The framework provides a structured way to align objectives, study design, and statistical analysis of randomised clinical trials. In particular, there is an emphasis on describing the relevant estimands in a transparent and structured way, and for thinking about strategies to handle what are called intercurrent events: things which happen after randomisation which affect the interpretability or availability of the final outcome measure. This talk will introduce the framework, and will primarily be of interest to those designing (or conducting) an RCT. However, it may also be of interest to people using the emulated target trial approach to analyse observational data, as many of the terms and concepts overlap.

About the speaker

Stephen Nash is a statistician in the applied biostatistics group at MEB. He received his MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine in 2013, and has since worked in trials in a variety of disease areas (cancer, psychology, HIV) and settings (UK, Uganda, South Africa, Sweden). He has a particular interest in cluster randomised trials and complex interventions.

Faculty lunch

Join the faculty event in Wargentin! After the seminar, the faculty lunch will be served in Ljusgården. The faculty lunches are intended for employees at MEB, and a monthly net salary deduction of 260 SEK will be made for those who work here 20% or more. If you have any questions about the lunch or specific dietary needs due to allergies, etc., please contact internservice@meb.ki.se. If you won’t be participating in the lunches for all or part of the spring term, our new routine is that you need to contact hr-support@meb.ki.se at the start of a new term, to be removed from the list. Retroactive adjustments will not be possible.  

Please, check the labeling on the salads not to take special diet foods that were pre-ordered by your colleagues.