Lectures and seminars Faculty event: Jie Song
Speaker: Jie Song
Title: Disentangling the heterogeneity of severe mental illness using cognitive-related traits
Severe mental illness (SMI), including schizophrenia, schizoaffective disorder, bipolar disorder and severe major depressive disorder are among the top contributors to the global burden of disease and affect over 300 million people. Individuals with the same diagnoses vary considerably in symptoms, trajectories, severity, and treatment responses, leaving heterogeneity a major research and clinical challenge. Cognitive deficits are often documented in SMI and have distinctive patterns within and across diagnoses. Combining cognitive measures before SMI onset may improve our understanding of its heterogeneity, and recent cognitive genetic findings have been applied to identify biological pathways of psychopathology. In this talk, I will present the recently published paper “The impact of educational attainment, intelligence and intellectual disability on schizophrenia: a Swedish population-based register and genetic study” (PMID: 35379910, DOI: 10.1038/s41380-022-01500-2). In this study, we investigated whether cognitive ability and intellectual disability might usefully index the etiological or phenotypic heterogeneity of schizophrenia. I will also present some future plans where the overall aims are to unravel the heterogeneity of SMI using multiple cognitive-related traits and cognitive genomics by leveraging register and genetic data.